Guidance on the management of diarrhoea during cancer chemotherapy

• Published in: The lancet oncology Vol. 15; no. 10; pp. e447 - e460
• Main Authors: Andreyev, Jervoise, Dr, Ross, Paul, FRCP, Donnellan, Clare, MRCP, Lennan, Elaine, RGN, Leonard, Pauline, FRCP, Waters, Caroline, BSc, Wedlake, Linda, RD, Bridgewater, John, PhD, Glynne-Jones, Rob, FRCR, Allum, William, FRCS, Chau, Ian, MD, Wilson, Richard, FRCP, Ferry, David, Prof
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.09.2014; Elsevier Limited
• Subjects: Antidiarrheals - therapeutic use; Antineoplastic Agents - adverse effects; Antineoplastic Agents - therapeutic use; Cancer; Chemotherapy; Clinical trials; Combined Modality Therapy; Dehydrogenases; Diarrhea - chemically induced; Diarrhea - mortality; Diarrhea - therapy; Drug therapy; Enzymes; Female; Fluid Therapy - methods; Hematology, Oncology and Palliative Medicine; Hospitals; Humans; Male; Multivariate analysis; Mutation; Neoplasms - drug therapy; Practice Guidelines as Topic; Risk Assessment; Severity of Illness Index; Survival Rate; Treatment Outcome

Summary Diarrhoea induced by chemotherapy in cancer patients is common, causes notable morbidity and mortality, and is managed inconsistently. Previous management guidelines were based on poor evidence and neglect physiological causes of chemotherapy-induced diarrhoea. In the absence of level 1 evid...