Heparanase Expression in Circulating Lymphocytes of Breast Cancer Patients Depends on the Presence of the Primary Tumor and/or Systemic Metastasis

• Published in: Neoplasia (New York, N.Y.) Vol. 9; no. 6; pp. 504 - 510
• Main Authors: Theodoro, Thérése Rachell, de Matos, Leandro Luongo, Lambiasi Sant Anna, Aleksandra Vanessa, Fonseca, Fernando Luiz Affonso, Semedo, Patrícia, Martins, Lourdes Conceição, Nader, Helena Bonciani, Del Giglio, Auro, da Silva Pinhal, Maria Aparecida
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2007; Neoplasia Press Inc; Elsevier
• Subjects: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; breast cancer; Breast Neoplasms - drug therapy; Breast Neoplasms - immunology; Case-Control Studies; Female; Gene Expression Regulation, Enzymologic; Glucuronidase - genetics; Heparanase; Humans; Immunoenzyme Techniques; Lymphatic Metastasis - pathology; lymphocytes; Lymphocytes - enzymology; metastasis; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - metabolism; Tumor Cells, Cultured; tumor markers; Heparanase; breast cancer; lymphocytes; tumor markers; metastasis

Heparanase is an endo-β-glucuronidase that is capable of degrading heparan sulfate chains of proteoglycans, generating a variety of bioactive molecules such as growth factors and chemotactic and angiogenic agents. The expression of heparanase was investigated in the peripheral blood mononuclear cell...