Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles - Joshi, P; Turola, E; Ruiz, A; Bergami, A; Libera, D D; Benussi, L; Giussani, P; Magnani, G; Comi, G; Legname, G; Ghidoni, R; Furlan, R; et al. (Cell death and differentiation, 2014)
Keywords: 631/378/1689/1283; 631/378/2596/1953; 692/420; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Amyloid beta-Peptides - chemistry; Amyloid beta-Peptides - toxicity; Animals; Apoptosis; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Cycle Analysis; Cell Survival - drug effects; Cells, Cultured; Excitatory Amino Acid Antagonists - pharmacology; Female; Humans; Interleukin-1beta - metabolism; Life Sciences; Male; Microglia - drug effects; Microglia - metabolism; Neurons - cytology; Neurons - drug effects; Neurons - metabolism; Original Paper; Peptide Fragments - chemistry; Peptide Fragments - toxicity; PrPC Proteins - metabolism; Rats; Solubility; Stem Cells; Transport Vesicles - chemistry; Transport Vesicles - metabolism; Tumor Necrosis Factor-alpha - metabolism; Alzheimer’s disease; microglia; extracellular microvesicles; Abeta 1–42; bioactive lipids; prion protein