Promises and Challenges of Cell-Based Therapies to Promote Lung Regeneration in Idiopathic Pulmonary Fibrosis

The lung epithelium is constantly exposed to harmful agents present in the air that we breathe making it highly susceptible to damage. However, in instances of injury to the lung, it exhibits a remarkable capacity to regenerate injured tissue thanks to the presence of distinct stem and progenitor ce...

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Published inCells (Basel, Switzerland) Vol. 11; no. 16; p. 2595
Main Authors Egea-Zorrilla, Alejandro, Vera, Laura, Saez, Borja, Pardo-Saganta, Ana
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.08.2022
MDPI
Subjects
alveolar epithelial cells
Alveoli
Care and treatment
cell therapy
Cellular therapy
Clinical trials
Disease
Epithelial cells
Epithelium
Etiology
Extracellular matrix
Fibroblasts
Fibrosis
Health aspects
Lung diseases
lung regeneration
Lungs
Methods
Pathogenesis
Physiology
Progenitor cells
Pulmonary fibrosis
Recovery of function
Regeneration (Biology)
Respiratory function
Review
Stem cells
stem/progenitor cells
Surfactants
tissue homeostasis
Transplantation
Transplants & implants
Wound healing
Germany
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Abstract The lung epithelium is constantly exposed to harmful agents present in the air that we breathe making it highly susceptible to damage. However, in instances of injury to the lung, it exhibits a remarkable capacity to regenerate injured tissue thanks to the presence of distinct stem and progenitor cell populations along the airway and alveolar epithelium. Mechanisms of repair are affected in chronic lung diseases such as idiopathic pulmonary fibrosis (IPF), a progressive life-threatening disorder characterized by the loss of alveolar structures, wherein excessive deposition of extracellular matrix components cause the distortion of tissue architecture that limits lung function and impairs tissue repair. Here, we review the most recent findings of a study of epithelial cells with progenitor behavior that contribute to tissue repair as well as the mechanisms involved in mouse and human lung regeneration. In addition, we describe therapeutic strategies to promote or induce lung regeneration and the cell-based strategies tested in clinical trials for the treatment of IPF. Finally, we discuss the challenges, concerns and limitations of applying these therapies of cell transplantation in IPF patients. Further research is still required to develop successful strategies focused on cell-based therapies to promote lung regeneration to restore lung architecture and function.
AbstractList The lung epithelium is constantly exposed to harmful agents present in the air that we breathe making it highly susceptible to damage. However, in instances of injury to the lung, it exhibits a remarkable capacity to regenerate injured tissue thanks to the presence of distinct stem and progenitor cell populations along the airway and alveolar epithelium. Mechanisms of repair are affected in chronic lung diseases such as idiopathic pulmonary fibrosis (IPF), a progressive life-threatening disorder characterized by the loss of alveolar structures, wherein excessive deposition of extracellular matrix components cause the distortion of tissue architecture that limits lung function and impairs tissue repair. Here, we review the most recent findings of a study of epithelial cells with progenitor behavior that contribute to tissue repair as well as the mechanisms involved in mouse and human lung regeneration. In addition, we describe therapeutic strategies to promote or induce lung regeneration and the cell-based strategies tested in clinical trials for the treatment of IPF. Finally, we discuss the challenges, concerns and limitations of applying these therapies of cell transplantation in IPF patients. Further research is still required to develop successful strategies focused on cell-based therapies to promote lung regeneration to restore lung architecture and function.
Audience Academic
Author Saez, Borja
Egea-Zorrilla, Alejandro
Vera, Laura
Pardo-Saganta, Ana
AuthorAffiliation 2 Cardio-Pulmonary Institute (CPI), Department of Internal Medicine, German Center for Lung Research (DZL), Justus Liebig University, 35392 Giessen, Germany
1 Institute for Lung Health (ILH), Department of Internal Medicine, Justus-Liebig University, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), 35392 Giessen, Germany
3 Solid Tumors Program, Division of Oncology, CIMA Universidad de Navarra, 31008 Pamplona, Spain
4 Department of Hematology-Oncology, CIMA Universidad de Navarra, 31008 Pamplona, Spain
AuthorAffiliation_xml – name: 4 Department of Hematology-Oncology, CIMA Universidad de Navarra, 31008 Pamplona, Spain
– name: 3 Solid Tumors Program, Division of Oncology, CIMA Universidad de Navarra, 31008 Pamplona, Spain
– name: 2 Cardio-Pulmonary Institute (CPI), Department of Internal Medicine, German Center for Lung Research (DZL), Justus Liebig University, 35392 Giessen, Germany
– name: 1 Institute for Lung Health (ILH), Department of Internal Medicine, Justus-Liebig University, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), 35392 Giessen, Germany
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  fullname: Egea-Zorrilla, Alejandro
– sequence: 2
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Snippet The lung epithelium is constantly exposed to harmful agents present in the air that we breathe making it highly susceptible to damage. However, in instances of...
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SubjectTerms alveolar epithelial cells
Alveoli
Care and treatment
cell therapy
Cellular therapy
Clinical trials
Disease
Epithelial cells
Epithelium
Etiology
Extracellular matrix
Fibroblasts
Fibrosis
Health aspects
Lung diseases
lung regeneration
Lungs
Methods
Pathogenesis
Physiology
Progenitor cells
Pulmonary fibrosis
Recovery of function
Regeneration (Biology)
Respiratory function
Review
Stem cells
stem/progenitor cells
Surfactants
tissue homeostasis
Transplantation
Transplants & implants
Wound healing
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Title Promises and Challenges of Cell-Based Therapies to Promote Lung Regeneration in Idiopathic Pulmonary Fibrosis
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Volume 11
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