Tracer kinetic studies of the low density lipoprotein metabolism in the fetal rat: an example for estimation of flux rates in the nonsteady state

• Published in: Journal of lipid research Vol. 31; no. 5; pp. 747 - 752
• Main Authors: Plonné, D, Schlag, B, Winkler, L, Dargel, R
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.1990; Elsevier
• Subjects: ANIMALS; Animals, Newborn; Apolipoproteins B - metabolism; BASIC BIOLOGICAL SCIENCES; BETA DECAY RADIOISOTOPES; CELL CONSTITUENTS; CELL MEMBRANES; DAYS LIVING RADIOISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; Female; Fetus - metabolism; FETUSES; INTERMEDIATE MASS NUCLEI; IODINE 125; IODINE ISOTOPES; Iodine Radioisotopes; ISOTOPE APPLICATIONS; ISOTOPES; Kinetics; LIPIDS; LIPOPROTEINS; Lipoproteins, LDL - metabolism; MAMMALS; MEMBRANES; METABOLISM; Models, Biological; Models, Theoretical; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; PREGNANCY; PROTEINS; RADIOISOTOPES; RATS; Rats, Inbred Strains; RODENTS; SECRETION; TRACER TECHNIQUES; VERTEBRATES 550501 > Metabolism > Tracer Techniques

To get insight into the low density lipoprotein (LDL)-apoB flux in the rat fetus near term and in the early postnatal period, homologous apoE-free 125I-labeled LDL was injected into the umbilical vein of the rat fetus immediately after Caesarean section. Since the serum LDL-apoB spontaneously declin...