Notch1 hallmarks fibrillary depositions in sporadic Alzheimer’s disease

• Published in: Acta neuropathologica communications Vol. 4; no. 1; p. 64
• Main Authors: Brai, Emanuele, Alina Raio, Noemi, Alberi, Lavinia
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01.07.2016; BioMed Central
• Subjects: Advertising executives; Aged; Aged, 80 and over; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease; Analysis; Animals; Biomarkers - cerebrospinal fluid; Blotting, Western; Brain; Cell Line, Tumor; Cerebral Cortex - metabolism; Cerebral Cortex - pathology; Disease Models, Animal; Female; Hippocampus - metabolism; Hippocampus - pathology; Humans; Immunohistochemistry; Injuries; Liver - metabolism; Liver - pathology; Male; Mice; Middle Aged; Neurons; Plaque, Amyloid - metabolism; Plaque, Amyloid - pathology; Receptor, Notch1 - metabolism; tau Proteins - metabolism; Thiazoles - metabolism; Tau; Cerebrospinal fluid; Sporadic Alzheimer’s disease; Notch1; Amyloid plaques

Notch1 signaling is a cellular cascade with a fundamental role from brain development to adult brain function. Reduction in Notch1 affects synaptic plasticity, memory and olfaction. On the other hand, Notch1 overactivation after brain injury is detrimental for neuronal survival. Some familial Alzhei...