Tropomyosin isoform modulation of focal adhesion structure and cell migration

• Published in: Cell adhesion & migration Vol. 4; no. 2; pp. 226 - 234
• Main Authors: Bach, Cuc T.T., Schevzov, Galina, Bryce, Nicole S., Gunning, Peter W., O'Neill, Geraldine M.
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.04.2010; Landes Bioscience
• Subjects: Animals; Binding; Biology; Bioscience; Calcium; Cancer; Cell; Cell Line, Tumor; Cell Movement - genetics; Cell Movement - physiology; Cycle; Focal Adhesions - metabolism; Landes; Microscopy, Fluorescence; Myosins - metabolism; Organogenesis; Protein Isoforms - metabolism; Proteins; Rats; Research Papers; Tropomyosin - genetics; Tropomyosin - metabolism

Orderly cell migration is essential for embryonic development, efficient wound healing and a functioning immune system and the dysregulation of this process leads to a number of pathologies. The speed and direction of cell migration is critically dependent on the structural organization of focal adh...