Tuftsin-tailored fusion protein inhibits the growth of circulating gastric tumor cells associated with macrophage phagocytosis

• Published in: Biochemistry and biophysics reports Vol. 34; p. 101443
• Main Authors: Yuan, Dandan, Zhai, Xiaoyang, Zhu, Kunli, Ji, Jiangang, Liu, Wenjuan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2023; Elsevier
• Subjects: CD47; Circulating tumor cells; Fusion protein; Lidamycin; Macrophage; Tuftsin; Lidamycin; CD47; Circulating tumor cells; Fusion protein; Tuftsin; Macrophage

Circulating tumor cells (CTCs) are a major cause of tumor metastasis and resistance to anticancer therapies. To date, no effective low-toxicity chemotherapeutic agents or antibodies have exhibited significant clinical activity against CTCs. Macrophages are important mediators of antitumor immunity....