The Histone H3 Lysine 4 Presenter WDR5 as an Oncogenic Protein and Novel Epigenetic Target in Cancer

• Published in: Frontiers in oncology Vol. 8; p. 502
• Main Authors: Lu, Kebin, Tao, He, Si, Xiaomin, Chen, Qingjuan
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 14.11.2018
• Subjects: cancer therapy; gene transcription; histone H3K4 methylation; MLL; Oncology; tumorigenesis; WDR5; WDR5; cancer therapy; gene transcription; tumorigenesis; MLL; histone H3K4 methylation

The histone H3 lysine 4 (H3K4) presenter WDR5 forms protein complexes with H3K4 methyltransferases MLL1-MLL4 and binding partner proteins including RBBP5, ASH2L, and DPY30, and plays a key role in histone H3K4 trimethylation, chromatin remodeling, transcriptional activation of target genes, normal b...