Kynurenine pathway, NAD+ synthesis, and mitochondrial function: Targeting tryptophan metabolism to promote longevity and healthspan

• Published in: Experimental gerontology Vol. 132; p. 110841
• Main Authors: Castro-Portuguez, Raul, Sutphin, George L.
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.04.2020
• Subjects: Aging - metabolism; Animals; Brain - metabolism; Humans; Kynurenine - metabolism; Kynurenine pathway; Longevity; Metabolic Networks and Pathways; Mice; Mitochondria; Mitochondria - physiology; Mitophagy; NAD; NAD - biosynthesis; Neurodegenerative Diseases - metabolism; Oxidation-Reduction; Oxidative stress; Oxidative Stress - physiology; Tryptophan; Tryptophan - metabolism; NAD; Tryptophan; Oxidative stress; Mitochondria; Kynurenine pathway

Aging is characterized by a progressive decline in the normal physiological functions of an organism, ultimately leading to mortality. Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor that plays a critical role in mitochondrial energy production as well as many enzymatic redox react...