Drosophila as a Model for Human Viral Neuroinfections

• Published in: Cells (Basel, Switzerland) Vol. 11; no. 17; p. 2685
• Main Authors: Benoit, Ilena, Di Curzio, Domenico, Civetta, Alberto, Douville, Renée N
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 29.08.2022; MDPI
• Subjects: Animal models in research; Autophagy; Bacteria; Brain research; Cytokines; Disease; Drosophila; Drosophila (fruit fly); Drug screening; Gene expression; Gram-negative bacteria; Gram-positive bacteria; Homeostasis; Immune system; immunity; infection; Infections; Insects; Interferon; Kinases; Mammals; Nervous system diseases; Neurodegeneration; neurological; Neurological diseases; Neurological disorders; Pathogenesis; Peptides; Phenotypes; Proteins; Review; Therapeutic targets; Transcription factors; transposable elements (TEs); Viral infections; virus; Virus diseases; Viruses; Canada

The study of human neurological infection faces many technical and ethical challenges. While not as common as mammalian models, the use of Drosophila (fruit fly) in the investigation of virus–host dynamics is a powerful research tool. In this review, we focus on the benefits and caveats of using Dro...