Intraduodenal nutrient infusion differentially alters intestinal nutrient sensing, appetite, and satiety responses in lean and obese subjects

• Published in: The American journal of clinical nutrition Vol. 118; no. 3; pp. 646 - 656
• Main Authors: Sundaresan, Sinju, Johnson, Connor, Dixon, Kala B., Dole, Michael, Kilkelly, Donna, Antoun, Joseph, Flynn, Charles Robb, Abumrad, Naji N., Tamboli, Robyn
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2023; American Society for Clinical Nutrition, Inc; American Society for Nutrition
• Subjects: Adult; analysis of variance; Appetite; benzocaine; blood; Body mass index; Body size; brain; c-peptide; Cholecystokinin; clinical nutrition; cross-over studies; Digestive system; Duodenum; Energy metabolism; Female; Food intake; Gastrointestinal tract; Ghrelin; Glucagon; Glucagon-like peptide 1; Glucose; gut peptides; Hormone release; Hormones; Humans; Hunger; Intervals; intestinal nutrient sensing; Intestine; Leptin; local anesthetics; Male; Nutrient release; Nutrients - administration & dosage; Nutritional status; Obesity; Obesity - therapy; Oleic acid; Original; Oxidation; pancreatic polypeptide; peptide YY; Peptides; Polypeptides; Satiety; Satiety Response; Thinness - therapy; vagal transmission; Vagus nerve; Variance analysis; EE; PP; satiety; MPE; vagal transmission; CCK; intestinal nutrient sensing; hunger; GIP; PYY; CRC; gut peptides; obesity

Intestinal nutrient sensing regulates food intake and energy metabolism by acting locally and relaying nutritional status to the brain. It is unclear whether these mechanisms are altered in obese humans. We aimed to investigate differences in duodenal nutrient sensing in humans with or without obesi...