Involvement of the mGluR1 Receptor in Hippocampal Synaptic Plasticity and Associative Learning in Behaving Mice

• Published in: Cerebral cortex (New York, N.Y. 1991) Vol. 18; no. 7; pp. 1653 - 1663
• Main Authors: Gil-Sanz, Cristina, Delgado-García, José M., Fairén, Alfonso, Gruart, Agnès
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.07.2008; Oxford Publishing Limited (England)
• Subjects: Animals; Association Learning - physiology; BAY36-7620; Behavior, Animal - physiology; classical conditioning; hippocampus; Hippocampus - physiology; long-term potentiation; Male; mGluR1 receptor; Mice; Mice, Knockout; Neuronal Plasticity - physiology; Neurons - physiology; Receptors, Metabotropic Glutamate - genetics; Receptors, Metabotropic Glutamate - metabolism; synaptic plasticity; Synaptic Transmission - physiology; mGluR1 receptor; BAY36-7620; synaptic plasticity; classical conditioning; hippocampus; long-term potentiation

Metabotropic glutamate receptor 1 (mGluR1) has been related to processes underlying learning in hippocampal circuits, but demonstrating its involvement in synaptic plasticity when measured directly on the relevant circuit of a learning animal has proved to be technically difficult. We have recorded...