Involvement of the mGluR1 Receptor in Hippocampal Synaptic Plasticity and Associative Learning in Behaving Mice
Metabotropic glutamate receptor 1 (mGluR1) has been related to processes underlying learning in hippocampal circuits, but demonstrating its involvement in synaptic plasticity when measured directly on the relevant circuit of a learning animal has proved to be technically difficult. We have recorded...
Saved in:
Published in | Cerebral cortex (New York, N.Y. 1991) Vol. 18; no. 7; pp. 1653 - 1663 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
Oxford University Press
01.07.2008
Oxford Publishing Limited (England) |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Metabotropic glutamate receptor 1 (mGluR1) has been related to processes underlying learning in hippocampal circuits, but demonstrating its involvement in synaptic plasticity when measured directly on the relevant circuit of a learning animal has proved to be technically difficult. We have recorded the functional changes taking place at the hippocampal CA3–CA1 synapse during the acquisition of an associative task in conscious mice carrying a targeted disruption of the mGluR1 gene. Animals were classically conditioned to evoke eyelid responses, using a trace (conditioned stimulus [CS], tone; unconditioned stimulus [US], electric shock) paradigm. Acquisition of this task was impaired in mutant mGluR1+/− mice and abolished in mGluR1−/− mice. A single pulse presented to Schaffer collaterals during the CS–US interval evoked a monosynaptic field excitatory postsynaptic potential at ipsilateral CA1 pyramidal cells, whose slope was linearly related to learning evolution in controls but not in mGluR1 mutants. Long-term potentiation evoked by train stimulation of Schaffer collaterals was also impaired in both mGluR1+/− and mGluR1−/− animals. Administration of the selective mGluR1 antagonist (3aS,6aS)-6a-naphthalen-2-ylmethyl-5-methyliden-hexahydro-cyclopental [c]furan-1-on to wild-type animals mimicked the functional changes associated to mGluR1 insufficiency in mutants. Thus, mGluR1 is required for activity-dependent synaptic plasticity and associative learning in behaving mice. |
---|---|
AbstractList | Metabotropic glutamate receptor 1 (mGluR1) has been related to processes underlying learning in hippocampal circuits, but demonstrating its involvement in synaptic plasticity when measured directly on the relevant circuit of a learning animal has proved to be technically difficult. We have recorded the functional changes taking place at the hippocampal CA3–CA1 synapse during the acquisition of an associative task in conscious mice carrying a targeted disruption of the mGluR1 gene. Animals were classically conditioned to evoke eyelid responses, using a trace (conditioned stimulus [CS], tone; unconditioned stimulus [US], electric shock) paradigm. Acquisition of this task was impaired in mutant mGluR1+/− mice and abolished in mGluR1−/− mice. A single pulse presented to Schaffer collaterals during the CS–US interval evoked a monosynaptic field excitatory postsynaptic potential at ipsilateral CA1 pyramidal cells, whose slope was linearly related to learning evolution in controls but not in mGluR1 mutants. Long-term potentiation evoked by train stimulation of Schaffer collaterals was also impaired in both mGluR1+/− and mGluR1−/− animals. Administration of the selective mGluR1 antagonist (3aS,6aS)-6a-naphthalen-2-ylmethyl-5-methyliden-hexahydro-cyclopental [c]furan-1-on to wild-type animals mimicked the functional changes associated to mGluR1 insufficiency in mutants. Thus, mGluR1 is required for activity-dependent synaptic plasticity and associative learning in behaving mice. Metabotropic glutamate receptor 1 (mGluR1) has been related to processes underlying learning in hippocampal circuits, but demonstrating its involvement in synaptic plasticity when measured directly on the relevant circuit of a learning animal has proved to be technically difficult. We have recorded the functional changes taking place at the hippocampal CA3-CA1 synapse during the acquisition of an associative task in conscious mice carrying a targeted disruption of the mGluR1 gene. Animals were classically conditioned to evoke eyelid responses, using a trace (conditioned stimulus [CS], tone; unconditioned stimulus [US], electric shock) paradigm. Acquisition of this task was impaired in mutant mGluR1[sup]+/- mice and abolished in mGluR1[sup]-/- mice. A single pulse presented to Schaffer collaterals during the CS-US interval evoked a monosynaptic field excitatory postsynaptic potential at ipsilateral CA1 pyramidal cells, whose slope was linearly related to learning evolution in controls but not in mGluR1 mutants. Long-term potentiation evoked by train stimulation of Schaffer collaterals was also impaired in both mGluR1[sup]+/- and mGluR1[sup]-/- animals. Administration of the selective mGluR1 antagonist (3aS,6aS)-6a-naphthalen-2-ylmethyl-5-methyliden-hexahydro-cyclopental [c]furan-1-on to wild-type animals mimicked the functional changes associated to mGluR1 insufficiency in mutants. Thus, mGluR1 is required for activity-dependent synaptic plasticity and associative learning in behaving mice. Metabotropic glutamate receptor 1 (mGluR1) has been related to processes underlying learning in hippocampal circuits, but demonstrating its involvement in synaptic plasticity when measured directly on the relevant circuit of a learning animal has proved to be technically difficult. We have recorded the functional changes taking place at the hippocampal CA3-CA1 synapse during the acquisition of an associative task in conscious mice carrying a targeted disruption of the mGluR1 gene. Animals were classically conditioned to evoke eyelid responses, using a trace (conditioned stimulus [CS], tone; unconditioned stimulus [US], electric shock) paradigm. Acquisition of this task was impaired in mutant mGluR1(+/-) mice and abolished in mGluR1(-/-) mice. A single pulse presented to Schaffer collaterals during the CS-US interval evoked a monosynaptic field excitatory postsynaptic potential at ipsilateral CA1 pyramidal cells, whose slope was linearly related to learning evolution in controls but not in mGluR1 mutants. Long-term potentiation evoked by train stimulation of Schaffer collaterals was also impaired in both mGluR1(+/-) and mGluR1(-/-) animals. Administration of the selective mGluR1 antagonist (3aS,6aS)-6a-naphthalen-2-ylmethyl-5-methyliden-hexahydro-cyclopental [c]furan-1-on to wild-type animals mimicked the functional changes associated to mGluR1 insufficiency in mutants. Thus, mGluR1 is required for activity-dependent synaptic plasticity and associative learning in behaving mice. Metabotropic glutamate receptor 1 (mGluR1) has been related to processes underlying learning in hippocampal circuits, but demonstrating its involvement in synaptic plasticity when measured directly on the relevant circuit of a learning animal has proved to be technically difficult. We have recorded the functional changes taking place at the hippocampal CA3-CA1 synapse during the acquisition of an associative task in conscious mice carrying a targeted disruption of the mGluR1 gene. Animals were classically conditioned to evoke eyelid responses, using a trace (conditioned stimulus [CS], tone; unconditioned stimulus [US], electric shock) paradigm. Acquisition of this task was impaired in mutant mGluR1 super(+/-) mice and abolished in mGluR1 super(-/-) mice. A single pulse presented to Schaffer collaterals during the CS-US interval evoked a monosynaptic field excitatory postsynaptic potential at ipsilateral CA1 pyramidal cells, whose slope was linearly related to learning evolution in controls but not in mGluR1 mutants. Long-term potentiation evoked by train stimulation of Schaffer collaterals was also impaired in both mGluR1 super(+/-) and mGluR1 super(-/-) animals. Administration of the selective mGluR1 antagonist (3aS,6aS)-6a-naphthalen-2-ylmethyl-5-methyliden-hexahydro-cyclopen t al [c]furan-1-on to wild-type animals mimicked the functional changes associated to mGluR1 insufficiency in mutants. Thus, mGluR1 is required for activity-dependent synaptic plasticity and associative learning in behaving mice. |
Author | Delgado-García, José M. Fairén, Alfonso Gruart, Agnès Gil-Sanz, Cristina |
Author_xml | – sequence: 1 givenname: Cristina surname: Gil-Sanz fullname: Gil-Sanz, Cristina organization: Instituto de Neurociencias de Alicante, CSIC and Universidad Miguel Hernández, E-03550 San Juan de Alicante, Spain – sequence: 2 givenname: José M. surname: Delgado-García fullname: Delgado-García, José M. organization: División de Neurociencias, Universidad Pablo de Olavide, Ctra. de Utrera, Km. 1, E-41013 Sevilla, Spain – sequence: 3 givenname: Alfonso surname: Fairén fullname: Fairén, Alfonso organization: Instituto de Neurociencias de Alicante, CSIC and Universidad Miguel Hernández, E-03550 San Juan de Alicante, Spain – sequence: 4 givenname: Agnès surname: Gruart fullname: Gruart, Agnès email: agrumas@upo.es organization: División de Neurociencias, Universidad Pablo de Olavide, Ctra. de Utrera, Km. 1, E-41013 Sevilla, Spain |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18024992$$D View this record in MEDLINE/PubMed |
BookMark | eNqF0ctv1DAQB2ALFdEXR67I4lBxCfUrDx_bFXQrtlAtICEuluNMWJfEDrazYv97ssoKpF56mjl8Hnv8O0VHzjtA6BUl7yiR_NJAMD5c1pueSv4MnVBRkIxRKY-mnogy44zSY3Qa4wMhtGQ5e4GOaUWYkJKdIH_rtr7bQg8uYd_itAHc33TjmuI1GBiSD9g6vLTD4I3uB93hLzunh2QNvu90nKpNO6xdg69i9MbqZLeAV6CDs-7n_uw1bPR2399ZA-foeau7CC8P9Qx9-_D-62KZrT7f3C6uVpnJWZ6y3AhJal6JZnonrwAqRiipidGENLVoJBRcNKImLTeMtYVmpshbVugcGl3Jhp-hi3nuEPzvEWJSvY0Guk478GNUhWRMFDR_EjIy_VlJ6QTfPIIPfgxuWkJRWZWCkUpMKJuRCT7GAK0agu112ClK1D4vNeel5rwm__owdKx7aP7rQ0ATeDsDPw5PzjrcbWOCP_-wDr9UUfIyV8vvP9SnBfnIrtelKvlfc5yxcA |
CitedBy_id | crossref_primary_10_1002_cne_23240 crossref_primary_10_1007_s10571_018_00647_3 crossref_primary_10_1155_2016_6212983 crossref_primary_10_1016_j_neuropharm_2012_06_005 crossref_primary_10_1016_j_ajhg_2012_07_019 crossref_primary_10_1186_s12974_015_0356_y crossref_primary_10_3892_ijmm_2023_5331 crossref_primary_10_1124_pr_108_000166 crossref_primary_10_1371_journal_pone_0032849 crossref_primary_10_2174_1570159X20666211223140303 crossref_primary_10_1016_j_pnpbp_2020_110174 crossref_primary_10_1016_j_ydbio_2018_03_023 crossref_primary_10_3233_JAD_201146 crossref_primary_10_1016_j_celrep_2019_06_071 crossref_primary_10_1002_ajmg_b_32253 crossref_primary_10_3390_ijms20061412 crossref_primary_10_1016_j_nlm_2015_04_006 crossref_primary_10_1016_j_ejphar_2009_12_043 crossref_primary_10_1016_j_jad_2013_05_035 crossref_primary_10_1038_s42003_020_01435_w crossref_primary_10_1016_j_ejmg_2019_103726 crossref_primary_10_1523_JNEUROSCI_2038_14_2014 crossref_primary_10_1016_j_neuropharm_2024_110036 crossref_primary_10_1016_j_pbb_2011_03_015 crossref_primary_10_1038_s41380_022_01589_5 crossref_primary_10_3390_genes13091667 crossref_primary_10_3390_toxics8040095 crossref_primary_10_1016_j_brainres_2009_11_059 crossref_primary_10_1152_jn_90384_2008 crossref_primary_10_3389_fnmol_2022_925049 crossref_primary_10_1016_j_bbr_2010_03_031 crossref_primary_10_1016_j_neulet_2013_08_030 crossref_primary_10_1111_j_1755_148X_2012_00983_x crossref_primary_10_1371_journal_pone_0129631 crossref_primary_10_3390_cancers13153874 crossref_primary_10_1073_pnas_1204599109 crossref_primary_10_1016_j_neuron_2019_08_017 crossref_primary_10_3389_fnbeh_2019_00098 crossref_primary_10_1124_pharmrev_121_000540 crossref_primary_10_1146_annurev_pharmtox_011008_145533 crossref_primary_10_1113_jphysiol_2011_209783 |
Cites_doi | 10.1016/j.nbd.2003.11.011 10.1126/science.280.5360.77 10.1113/jphysiol.2006.112896 10.1038/12137 10.1126/science.1128134 10.1113/jphysiol.1973.sp010274 10.1046/j.1460-9568.2002.02407.x 10.1016/0028-3908(94)00129-G 10.1016/0896-6273(93)90086-7 10.1016/S0006-8993(97)00320-X 10.1152/jn.2001.86.5.2571 10.1523/JNEUROSCI.4388-04.2005 10.1146/annurev.physiol.64.092501.114547 10.1038/361031a0 10.1016/0014-2999(96)00138-0 10.1146/annurev.ps.37.020186.002245 10.1124/mol.59.5.965 10.1152/jn.1983.50.5.1197 10.1093/brain/75.3.385 10.1152/jn.1995.74.1.226 10.1016/0166-2236(88)90141-5 10.1038/372237a0 10.1016/j.neuropharm.2005.05.016 10.1111/j.1460-9568.2004.03643.x 10.1523/JNEUROSCI.4055-06.2007 10.1152/jn.1991.66.1.40 10.1523/JNEUROSCI.2834-05.2006 10.1111/j.1460-9568.1996.tb01611.x 10.1111/j.1460-9568.1994.tb00599.x 10.1002/hipo.10163 10.1111/j.1460-9568.2005.03940.x 10.1016/0006-8993(78)90030-6 10.1111/j.1460-9568.2005.03864.x 10.1046/j.1471-4159.2000.0750889.x 10.1002/(SICI)1096-9861(19981026)400:3<391::AID-CNE8>3.0.CO;2-3 10.1101/lm.428307 10.1037/0735-7044.104.2.243 10.1016/S0896-6273(00)80665-0 10.1038/363347a0 10.1523/JNEUROSCI.21-16-05925.2001 10.1152/jn.2000.83.2.836 10.1038/nn910 10.1523/JNEUROSCI.23-01-00017.2003 10.1146/annurev.pharmtox.37.1.205 10.1111/j.1460-9568.2005.04488.x 10.1016/0092-8674(94)90204-6 10.1007/s00441-006-0266-5 10.1152/jn.1997.78.2.1184 10.1016/0306-4522(83)90010-6 10.1152/jn.1997.78.2.1030 10.1523/JNEUROSCI.23-04-01535.2003 10.1126/science.1128657 |
ContentType | Journal Article |
Copyright | The Author 2007. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org 2008 The Author 2007. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org |
Copyright_xml | – notice: The Author 2007. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org 2008 – notice: The Author 2007. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org |
DBID | BSCLL CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QR 7TK 7U7 8FD C1K FR3 K9. P64 7X8 |
DOI | 10.1093/cercor/bhm193 |
DatabaseName | Istex Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Chemoreception Abstracts Neurosciences Abstracts Toxicology Abstracts Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database ProQuest Health & Medical Complete (Alumni) Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Technology Research Database Toxicology Abstracts ProQuest Health & Medical Complete (Alumni) Chemoreception Abstracts Engineering Research Database Neurosciences Abstracts Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic |
DatabaseTitleList | Technology Research Database MEDLINE Neurosciences Abstracts MEDLINE - Academic |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Anatomy & Physiology |
EISSN | 1460-2199 |
EndPage | 1663 |
ExternalDocumentID | 1497467231 10_1093_cercor_bhm193 18024992 10.1093/cercor/bhm193 ark_67375_HXZ_NC0K2BR7_7 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GroupedDBID | --- -E4 .2P .I3 .ZR 0R~ 1TH 29B 2WC 4.4 482 48X 53G 5GY 5RE 5VS 5WA 5WD 70D AABJS AABMN AABZA AACZT AAESY AAIMJ AAIYJ AAJKP AAJQQ AAMDB AAMVS AAOGV AAPNW AAPQZ AAPXW AARHZ AASNB AAUQX AAVAP AAVLN ABEUO ABIVO ABIXL ABJNI ABKDP ABLJU ABMNT ABNHQ ABNKS ABPTD ABQLI ABQTQ ABSAR ABWST ABXVV ABZBJ ACGFS ACIMA ACIWK ACPRK ACUFI ACUTJ ACUTO ADBBV ADEIU ADEYI ADEZT ADFTL ADGKP ADGZP ADHKW ADHZD ADIPN ADJQC ADOCK ADORX ADQLU ADRIX ADRTK ADVEK ADYVW ADZTZ ADZXQ AEGPL AEJOX AEKSI AELWJ AEMDU AENEX AENZO AEPUE AETBJ AEWNT AFFZL AFGWE AFIYH AFOFC AFRAH AFXEN AGINJ AGKEF AGQXC AGSYK AHMBA AHXPO AIJHB AIKOY AIMBJ AJEEA AKHUL AKWXX ALMA_UNASSIGNED_HOLDINGS ALUQC APIBT APWMN ARIXL ASMCH ASPBG AVWKF AWCFO AXUDD AYOIW AZFZN AZQFJ BAWUL BAYMD BCRHZ BEYMZ BGYMP BHONS BQDIO BSCLL BSWAC BTRTY BVRKM BYORX C1A CAG CASEJ CDBKE COF CS3 CZ4 DAKXR DIK DILTD DPORF DPPUQ DU5 D~K E3Z EBS EE~ EJD EMOBN F5P F9B FEDTE FHSFR FLUFQ FOEOM FOTVD FQBLK GAUVT GJXCC H5~ HAR HVGLF HW0 HZ~ IOX J21 JXSIZ KAQDR KBUDW KOP KQ8 KSI KSN M-Z M49 ML0 N9A NGC NLBLG NOMLY NOYVH NTWIH NU- NVLIB O0~ O9- OAWHX OBOKY OCZFY ODMLO OJQWA OJZSN OK1 OPAEJ OVD OWPYF P2P P6G PAFKI PB- PEELM PQQKQ Q1. Q5Y QBD R44 RD5 RIG ROL ROX ROZ RUSNO RW1 RXO TCN TEORI TJX TLC TR2 W8F WOQ X7H YAYTL YKOAZ YXANX ZKX ~91 .GJ 6.Y AAPGJ AAUAY AAWDT ABSMQ ACFRR ACMRT ACPQN ACZBC ADQBN AEKPW AFFNX AFSHK AFYAG AGKRT AGMDO ANFBD APJGH AQDSO AQKUS ASAOO ATDFG ATGXG ATTQO AVNTJ BZKNY CXTWN DFGAJ EIHJH ELUNK H13 KC5 MBLQV MBTAY O~Y RNI RZF RZO TMA UQL AEHUL CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QR 7TK 7U7 8FD C1K FR3 K9. P64 7X8 |
ID | FETCH-LOGICAL-c525t-5c490b384d24938ee82010b0ca00db4d9e634d4b0f3c22f6a2c65f26a5eda89d3 |
ISSN | 1047-3211 |
IngestDate | Fri Aug 16 23:19:42 EDT 2024 Sun Sep 29 07:26:11 EDT 2024 Fri Sep 13 09:20:37 EDT 2024 Thu Sep 12 16:38:41 EDT 2024 Sat Sep 28 07:53:43 EDT 2024 Wed Aug 28 03:24:10 EDT 2024 Sun Mar 31 11:38:02 EDT 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 7 |
Keywords | mGluR1 receptor BAY36-7620 synaptic plasticity classical conditioning hippocampus long-term potentiation |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c525t-5c490b384d24938ee82010b0ca00db4d9e634d4b0f3c22f6a2c65f26a5eda89d3 |
Notes | istex:93BA2EDB3FFD29D99E71897283545D2FDF5D3C3E ark:/67375/HXZ-NC0K2BR7-7 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
OpenAccessLink | https://academic.oup.com/cercor/article-pdf/18/7/1653/1173411/bhm193.pdf |
PMID | 18024992 |
PQID | 198742084 |
PQPubID | 31422 |
PageCount | 11 |
ParticipantIDs | proquest_miscellaneous_69224615 proquest_miscellaneous_20725711 proquest_journals_198742084 crossref_primary_10_1093_cercor_bhm193 pubmed_primary_18024992 oup_primary_10_1093_cercor_bhm193 istex_primary_ark_67375_HXZ_NC0K2BR7_7 |
PublicationCentury | 2000 |
PublicationDate | 2008-07-01 |
PublicationDateYYYYMMDD | 2008-07-01 |
PublicationDate_xml | – month: 07 year: 2008 text: 2008-07-01 day: 01 |
PublicationDecade | 2000 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States – name: Oxford |
PublicationTitle | Cerebral cortex (New York, N.Y. 1991) |
PublicationTitleAlternate | Cereb Cortex |
PublicationYear | 2008 |
Publisher | Oxford University Press Oxford Publishing Limited (England) |
Publisher_xml | – name: Oxford University Press – name: Oxford Publishing Limited (England) |
References | Pastalkova (40_22532872) 2006; 313 (36_24729257) 2000; 26 Gruart (23_28899119) 2007; 14 Pin (42_15954327) 1995; 34 Berger (4_13040649) 1983; 50 Eichenbaum (16_10940995) 1999; 2 Levy (28_8996486) 1983; 8 McEchron (32_5742717) 1997; 78 Clark (11_5948174) 1998; 280 Mannaioni (30_11265301) 2001; 21 Kaneda (25_21279274) 2005; 22 Bliss (6_12521465) 1973; 232 (12_28463284) 1997; 37 Conquet (13_15670604) 1994; 372 Bashir (2_10241452) 1993; 363 (7_29890423) 1996; 301 Naie (39_18644283) 2005; 21 Lujan (29_16326904) 1996; 8 Dom nguez-del-Toro (15_18442868) 2004; 20 Moyer (35_5653478) 1990; 104 Aiba (1_15654498) 1994; 79 Baude (3_14458154) 1993; 11 Bliss (5_10107104) 1993; 361 Kishimoto (26_17381208) 2002; 16 Reisel (45_17210056) 2002; 5 Takatsuki (49_17464089) 2003; 23 (51_22209918) 2006; 575 Rodr guez-Moreno (46_6288576) 1998; 21 KUGELBERG (27_3010496) 1952; 75 Cartmell (10_10430342) 2000; 75 Gruart (22_6466464) 2000; 83 Gureviciene (24_18077261) 2004; 15 Ferraguti (19_22637710) 2006; 326 Manzoni (31_15651835) 1994; 6 Thompson (50_5229388) 1988; 11 Woody (54_13794687) 1986; 37 Carroll (9_11115227) 2001; 59 Whitlock (53_22527918) 2006; 313 Porras-Garc a (43_18756112) 2005; 21 McNaughton (34_4686474) 1978; 157 (38_28651765) 2005; 49 Gruart (21_21452863) 2006; 26 Munera (37_11391389) 2001; 86 Power (44_5742733) 1997; 78 Topolnik (52_18644591) 2005; 25 Ferraguti (17_18146918) 2004; 14 Bordi (8_16865611) 1997; 761 Zucker (55_16898457) 2002; 64 Sahun (47_23683823) 2007; 27 McEchron (33_17511159) 2003; 23 Ferraguti (18_6189557) 1998; 400 Gruart (20_16074830) 1995; 74 Desai (14_9595250) 1991; 66 |
References_xml | – volume: 15 start-page: 188 issn: 0969-9961 issue: 2 year: 2004 ident: 24_18077261 publication-title: Neurobiology of disease doi: 10.1016/j.nbd.2003.11.011 contributor: fullname: Gureviciene – volume: 280 start-page: 77 issn: 0036-8075 issue: 5360 year: 1998 ident: 11_5948174 publication-title: Science doi: 10.1126/science.280.5360.77 contributor: fullname: Clark – volume: 575 start-page: 115 issn: 0022-3751 issue: 1 year: 2006 ident: 51_22209918 publication-title: The Journal of Physiology doi: 10.1113/jphysiol.2006.112896 – volume: 2 start-page: 775 issn: 1097-6256 issue: 9 year: 1999 ident: 16_10940995 publication-title: Nature neuroscience doi: 10.1038/12137 contributor: fullname: Eichenbaum – volume: 313 start-page: 1093 issn: 0036-8075 issue: 5790 year: 2006 ident: 53_22527918 publication-title: Science doi: 10.1126/science.1128134 contributor: fullname: Whitlock – volume: 232 start-page: 357 issn: 0022-3751 issue: 2 year: 1973 ident: 6_12521465 publication-title: The Journal of Physiology doi: 10.1113/jphysiol.1973.sp010274 contributor: fullname: Bliss – volume: 16 start-page: 2416 issn: 0953-816X issue: 12 year: 2002 ident: 26_17381208 publication-title: The European journal of neuroscience doi: 10.1046/j.1460-9568.2002.02407.x contributor: fullname: Kishimoto – volume: 34 start-page: 1 issn: 0028-3908 issue: 1 year: 1995 ident: 42_15954327 publication-title: Neuropharmacology doi: 10.1016/0028-3908(94)00129-G contributor: fullname: Pin – volume: 11 start-page: 771 issn: 0896-6273 issue: 4 year: 1993 ident: 3_14458154 publication-title: Neuron doi: 10.1016/0896-6273(93)90086-7 contributor: fullname: Baude – volume: 761 start-page: 121 issn: 0006-8993 issue: 1 year: 1997 ident: 8_16865611 publication-title: Brain research doi: 10.1016/S0006-8993(97)00320-X contributor: fullname: Bordi – volume: 86 start-page: 2571 issn: 0022-3077 issue: 5 year: 2001 ident: 37_11391389 publication-title: Journal of Neurophysiology doi: 10.1152/jn.2001.86.5.2571 contributor: fullname: Munera – volume: 25 start-page: 990 issn: 0270-6474 issue: 4 year: 2005 ident: 52_18644591 publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.4388-04.2005 contributor: fullname: Topolnik – volume: 64 start-page: 355 issn: 0066-4278 issue: 1 year: 2002 ident: 55_16898457 publication-title: Annual Review of Physiology doi: 10.1146/annurev.physiol.64.092501.114547 contributor: fullname: Zucker – volume: 361 start-page: 31 issn: 1476-4687 issue: 6407 year: 1993 ident: 5_10107104 publication-title: Nature; Physical Science (London) doi: 10.1038/361031a0 contributor: fullname: Bliss – volume: 301 start-page: 15 issn: 0014-2999 year: 1996 ident: 7_29890423 publication-title: European journal of pharmacology doi: 10.1016/0014-2999(96)00138-0 – volume: 37 start-page: 433 issn: 0066-4308 issue: 1 year: 1986 ident: 54_13794687 publication-title: Annual review of psychology doi: 10.1146/annurev.ps.37.020186.002245 contributor: fullname: Woody – volume: 59 start-page: 965 issn: 0026-895X issue: 5 year: 2001 ident: 9_11115227 publication-title: Molecular Pharmacology doi: 10.1124/mol.59.5.965 contributor: fullname: Carroll – volume: 50 start-page: 1197 issn: 0022-3077 issue: 5 year: 1983 ident: 4_13040649 publication-title: Journal of Neurophysiology doi: 10.1152/jn.1983.50.5.1197 contributor: fullname: Berger – volume: 75 start-page: 385 issn: 0006-8950 issue: 3 year: 1952 ident: 27_3010496 publication-title: Brain doi: 10.1093/brain/75.3.385 contributor: fullname: KUGELBERG – volume: 74 start-page: 226 issn: 0022-3077 issue: 1 year: 1995 ident: 20_16074830 publication-title: Journal of Neurophysiology doi: 10.1152/jn.1995.74.1.226 contributor: fullname: Gruart – volume: 26 start-page: 1650 year: 2000 ident: 36_24729257 publication-title: ABSTRACTS OF THE SOCIETY FOR NEUROSCIENCE – volume: 11 start-page: 152 issn: 0166-2236 issue: 4 year: 1988 ident: 50_5229388 publication-title: Trends in neurosciences doi: 10.1016/0166-2236(88)90141-5 contributor: fullname: Thompson – volume: 372 start-page: 237 issn: 1476-4687 issue: 6503 year: 1994 ident: 13_15670604 publication-title: Nature; Physical Science (London) doi: 10.1038/372237a0 contributor: fullname: Conquet – volume: 49 start-page: 179 issn: 0028-3908 year: 2005 ident: 38_28651765 publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2005.05.016 – volume: 20 start-page: 1945 issn: 0953-816X issue: 7 year: 2004 ident: 15_18442868 publication-title: The European journal of neuroscience doi: 10.1111/j.1460-9568.2004.03643.x contributor: fullname: Dom nguez-del-Toro – volume: 27 start-page: 2253 issn: 0270-6474 issue: 9 year: 2007 ident: 47_23683823 publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.4055-06.2007 contributor: fullname: Sahun – volume: 66 start-page: 40 issn: 0022-3077 issue: 1 year: 1991 ident: 14_9595250 publication-title: Journal of Neurophysiology doi: 10.1152/jn.1991.66.1.40 contributor: fullname: Desai – volume: 26 start-page: 1077 issn: 0270-6474 issue: 4 year: 2006 ident: 21_21452863 publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.2834-05.2006 contributor: fullname: Gruart – volume: 8 start-page: 1488 issn: 0953-816X issue: 7 year: 1996 ident: 29_16326904 publication-title: The European journal of neuroscience doi: 10.1111/j.1460-9568.1996.tb01611.x contributor: fullname: Lujan – volume: 6 start-page: 1050 issn: 0953-816X issue: 6 year: 1994 ident: 31_15651835 publication-title: The European journal of neuroscience doi: 10.1111/j.1460-9568.1994.tb00599.x contributor: fullname: Manzoni – volume: 14 start-page: 193 issn: 1050-9631 issue: 2 year: 2004 ident: 17_18146918 publication-title: Hippocampus doi: 10.1002/hipo.10163 contributor: fullname: Ferraguti – volume: 21 start-page: 979 issn: 0953-816X issue: 4 year: 2005 ident: 43_18756112 publication-title: The European journal of neuroscience doi: 10.1111/j.1460-9568.2005.03940.x contributor: fullname: Porras-Garc a – volume: 157 start-page: 277 issn: 0006-8993 issue: 2 year: 1978 ident: 34_4686474 publication-title: Brain research doi: 10.1016/0006-8993(78)90030-6 contributor: fullname: McNaughton – volume: 21 start-page: 411 issn: 0953-816X issue: 2 year: 2005 ident: 39_18644283 publication-title: The European journal of neuroscience doi: 10.1111/j.1460-9568.2005.03864.x contributor: fullname: Naie – volume: 75 start-page: 889 issn: 0022-3042 issue: 3 year: 2000 ident: 10_10430342 publication-title: Journal of neurochemistry doi: 10.1046/j.1471-4159.2000.0750889.x contributor: fullname: Cartmell – volume: 400 start-page: 391 issn: 0021-9967 issue: 3 year: 1998 ident: 18_6189557 publication-title: The Journal of comparative neurology doi: 10.1002/(SICI)1096-9861(19981026)400:3<391::AID-CNE8>3.0.CO;2-3 contributor: fullname: Ferraguti – volume: 14 start-page: 54 issn: 1072-0502 issue: 1-2 year: 2007 ident: 23_28899119 publication-title: Learning & Memory doi: 10.1101/lm.428307 contributor: fullname: Gruart – volume: 104 start-page: 243 issn: 0735-7044 issue: 2 year: 1990 ident: 35_5653478 publication-title: Behavioral neuroscience doi: 10.1037/0735-7044.104.2.243 contributor: fullname: Moyer – volume: 21 start-page: 1477 issn: 0896-6273 issue: 6 year: 1998 ident: 46_6288576 publication-title: Neuron doi: 10.1016/S0896-6273(00)80665-0 contributor: fullname: Rodr guez-Moreno – volume: 363 start-page: 347 issn: 1476-4687 issue: 6427 year: 1993 ident: 2_10241452 publication-title: Nature; Physical Science (London) doi: 10.1038/363347a0 contributor: fullname: Bashir – volume: 21 start-page: 5925 issn: 0270-6474 issue: 16 year: 2001 ident: 30_11265301 publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.21-16-05925.2001 contributor: fullname: Mannaioni – volume: 83 start-page: 836 issn: 0022-3077 issue: 2 year: 2000 ident: 22_6466464 publication-title: Journal of Neurophysiology doi: 10.1152/jn.2000.83.2.836 contributor: fullname: Gruart – volume: 5 start-page: 868 issn: 1097-6256 issue: 9 year: 2002 ident: 45_17210056 publication-title: Nature neuroscience doi: 10.1038/nn910 contributor: fullname: Reisel – volume: 23 start-page: 17 issn: 0270-6474 issue: 1 year: 2003 ident: 49_17464089 publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.23-01-00017.2003 contributor: fullname: Takatsuki – volume: 37 start-page: 205 issn: 1545-4304 year: 1997 ident: 12_28463284 publication-title: Annual review of pharmacology and toxicology doi: 10.1146/annurev.pharmtox.37.1.205 – volume: 22 start-page: 3241 issn: 0953-816X issue: 12 year: 2005 ident: 25_21279274 publication-title: The European journal of neuroscience doi: 10.1111/j.1460-9568.2005.04488.x contributor: fullname: Kaneda – volume: 79 start-page: 365 issn: 0092-8674 issue: 2 year: 1994 ident: 1_15654498 publication-title: Cell doi: 10.1016/0092-8674(94)90204-6 contributor: fullname: Aiba – volume: 326 start-page: 483 issn: 0302-766X issue: 2 year: 2006 ident: 19_22637710 publication-title: Cell and tissue research doi: 10.1007/s00441-006-0266-5 contributor: fullname: Ferraguti – volume: 78 start-page: 1184 issn: 0022-3077 issue: 2 year: 1997 ident: 44_5742733 publication-title: Journal of Neurophysiology doi: 10.1152/jn.1997.78.2.1184 contributor: fullname: Power – volume: 8 start-page: 791 issn: 0306-4522 issue: 4 year: 1983 ident: 28_8996486 publication-title: Neuroscience doi: 10.1016/0306-4522(83)90010-6 contributor: fullname: Levy – volume: 78 start-page: 1030 issn: 0022-3077 issue: 2 year: 1997 ident: 32_5742717 publication-title: Journal of Neurophysiology doi: 10.1152/jn.1997.78.2.1030 contributor: fullname: McEchron – volume: 23 start-page: 1535 issn: 0270-6474 issue: 4 year: 2003 ident: 33_17511159 publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.23-04-01535.2003 contributor: fullname: McEchron – volume: 313 start-page: 1141 issn: 0036-8075 issue: 5790 year: 2006 ident: 40_22532872 publication-title: Science doi: 10.1126/science.1128657 contributor: fullname: Pastalkova |
SSID | ssj0017252 |
Score | 2.2030115 |
Snippet | Metabotropic glutamate receptor 1 (mGluR1) has been related to processes underlying learning in hippocampal circuits, but demonstrating its involvement in... |
SourceID | proquest crossref pubmed oup istex |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 1653 |
SubjectTerms | Animals Association Learning - physiology BAY36-7620 Behavior, Animal - physiology classical conditioning hippocampus Hippocampus - physiology long-term potentiation Male mGluR1 receptor Mice Mice, Knockout Neuronal Plasticity - physiology Neurons - physiology Receptors, Metabotropic Glutamate - genetics Receptors, Metabotropic Glutamate - metabolism synaptic plasticity Synaptic Transmission - physiology |
Title | Involvement of the mGluR1 Receptor in Hippocampal Synaptic Plasticity and Associative Learning in Behaving Mice |
URI | https://api.istex.fr/ark:/67375/HXZ-NC0K2BR7-7/fulltext.pdf https://www.ncbi.nlm.nih.gov/pubmed/18024992 https://www.proquest.com/docview/198742084/abstract/ https://search.proquest.com/docview/20725711 https://search.proquest.com/docview/69224615 |
Volume | 18 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLbKJiFeEGxcyrgYCe2lypY4di6PY2XtmDqhXaSJl8ixnVHRJlWXoo3_zTvHdpJ2WweDlyhKnMjJ-XLOsc_nLwh98AMVKQ8GOW4giUMh5DmRpHqo4gqmPMqEWeU6OAz6p_TzGTtrtX4tsJZmZbolfi5dV_I_VoVjYFe9SvYfLNvcFA7APtgXtmBh2N7Lxvs5OBcj-F3Wtf5xbzQ78nQ2qCal4Zp3-sPJBCIWfPejzvFVzidao_ULZM2aUF1a_aXGSj9ULblqlrpY-UTYH1QcuUbVQE11yVmLi0xLdbnspz4dzXdamGnoDUfOMaSiZm7W-Ja8iQldNTrnsnB68N2Z2n2XV_UJW8nvDLYapPFhVd636gejDF5vMecRaZaqOXGem2bR9ZmNqGHBln9aMbngrLXKhE8qZ63sMRq4DnjheLmHn9W8ZOuuvcAqFVeh3wuss70VVqzkllBToedQ9tJvYy_25xG0Zg3cCKwN3ZFPv2v-XMiS_tnX5HDXPSAfj8IkfIBWSRgzPWfQ3T9oil8hYaQW0dCPV0nDQie2bRe2bQeupVKr2itc3limeWu0ZLKmkyfocTXcwTsWu09RS-VraH0n52UxvsKb2BCQTWVnDT0cVDyPdVQsIBsXGQZkY4tsXCMbD3O8gGxcIxvPkY0B2XgB2bhGtr62RjbWyH6GTvc-nez2nerXII5ghJUOEzR2Uz-iktDYj5TSiaybuoK7rkypjFXgU0lTN_MFIVnAiQhYRgLOlORRLP3naCUvcvUSYRESIkPhCQE3lSpNvQDS4tTPpIxcEfI22qzfcjKxCjCJZW74iTVHYs0BDY0NmlZ3mb2N3oOR_nazjdqESeVxLhI9QajpMLSN3jVnIRzoGh_PVTG7SIgL6Ak97-4WQWw0JFkbvbDImHck0vqhMXl13wfZQI_m3-1rtFJOZ-oN5Ohl-tYg-je-LeZr |
link.rule.ids | 315,786,790,27957,27958 |
linkProvider | Flying Publisher |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Involvement+of+the+mGluR1+Receptor+in+Hippocampal+Synaptic+Plasticity+and+Associative+Learning+in+Behaving+Mice&rft.jtitle=Cerebral+cortex+%28New+York%2C+N.Y.+1991%29&rft.au=Gil-Sanz%2C+Cristina&rft.au=Delgado-Garc%C3%ADa%2C+Jos%C3%A9+M.&rft.au=Fair%C3%A9n%2C+Alfonso&rft.au=Gruart%2C+Agn%C3%A8s&rft.date=2008-07-01&rft.pub=Oxford+University+Press&rft.issn=1047-3211&rft.eissn=1460-2199&rft.volume=18&rft.issue=7&rft.spage=1653&rft.epage=1663&rft_id=info:doi/10.1093%2Fcercor%2Fbhm193&rft.externalDBID=n%2Fa&rft.externalDocID=ark_67375_HXZ_NC0K2BR7_7 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1047-3211&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1047-3211&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1047-3211&client=summon |