Efficacy and safety of dolutegravir with emtricitabine and tenofovir alafenamide fumarate or tenofovir disoproxil fumarate, and efavirenz, emtricitabine, and tenofovir disoproxil fumarate HIV antiretroviral therapy regimens started in pregnancy (IMPAACT 2010/VESTED): a multicentre, open-label, randomised, controlled, phase 3 trial - Lockman, Shahin; Brummel, Sean S; Ziemba, Lauren; Stranix-Chibanda, Lynda; McCarthy, Katie; Coletti, Anne; Jean-Philippe, Patrick; Johnston, Ben; Krotje, Chelsea; Fairlie, Lee; Hoffman, Risa M; Sax, Paul E; et al. (The Lancet (British edition), 2021)
Keywords: Adenine - administration & dosage; Adenine - adverse effects; Adenine - analogs & derivatives; Adult; Adverse events; Age; Alanine; Allergies; Analysis; Anti-HIV agents; Anti-HIV Agents - administration & dosage; Anti-HIV Agents - adverse effects; Antiretroviral agents; Antiretroviral drugs; Antiretroviral therapy; Antiviral agents; Biometrics; CD4 antigen; Clinical trials; Creatinine; Disease transmission; Dosage; Drug dosages; Drug resistance; Drug therapy; Drug Therapy, Combination; Efavirenz; Emtricitabine; Emtricitabine - administration & dosage; Emtricitabine - adverse effects; Female; Fetuses; Gestation; Gestational Age; Heterocyclic Compounds, 3-Ring - administration & dosage; Heterocyclic Compounds, 3-Ring - adverse effects; Highly active antiretroviral therapy; HIV; HIV (Viruses); HIV Infections - drug therapy; HIV Infections - prevention & control; Human immunodeficiency virus; Humans; Infant mortality; Infant, Newborn; Infants; Infectious Disease Transmission, Vertical - prevention & control; Infectious diseases; Mental health; Miscarriage; Neonates; Oxazines - administration & dosage; Oxazines - adverse effects; Piperazines - administration & dosage; Piperazines - adverse effects; Pregnancy; Pregnancy Complications, Infectious - drug therapy; Pregnancy Outcome; Pregnant women; Premature birth; Public health; Pyridones - administration & dosage; Pyridones - adverse effects; Randomization; Ribonucleic acid; RNA; Safety; Secondary analysis; Small for gestational age; Stillbirth; Tenofovir; Tenofovir - administration & dosage; Tenofovir - adverse effects; Ultrasonic imaging; Ultrasonography, Prenatal; Womens health; South Africa; Botswana; United States--US