Modulation of FLT3 signal transduction through cytoplasmic cysteine residues indicates the potential for redox regulation

• Published in: Redox biology Vol. 28; p. 101325
• Main Authors: Böhmer, Annette, Barz, Saskia, Schwab, Katjana, Kolbe, Ulrike, Gabel, Anke, Kirkpatrick, Joanna, Ohlenschläger, Oliver, Görlach, Matthias, Böhmer, Frank-D.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2020; Elsevier
• Subjects: Cell Line; Cyclohexanones - pharmacology; Cysteine - metabolism; Cysteine residues; Cytoplasm - metabolism; FLT3; Fms-like tyrosine kinase; fms-Like Tyrosine Kinase 3 - chemistry; fms-Like Tyrosine Kinase 3 - genetics; fms-Like Tyrosine Kinase 3 - metabolism; HEK293 Cells; Humans; Leukemic cell transformation; Models, Molecular; Mutation; Oxidation; Oxidation-Reduction; Protein Conformation; Reactive Oxygen Species - metabolism; Research Paper; Signal Transduction; Signal transduction; Fms-like tyrosine kinase; Oxidation; Leukemic cell transformation; FLT3; Cysteine residues

Oxidative modification of cysteine residues has been shown to regulate the activity of several protein-tyrosine kinases. We explored the possibility that Fms-like tyrosine kinase 3 (FLT3), a hematopoietic receptor-tyrosine kinase, is subject to this type of regulation. An underlying rationale was th...