Atypical memory B cells from natural malaria infection produced broadly neutralizing antibodies against Plasmodium vivax variants

• Published in: PLoS pathogens Vol. 21; no. 1; p. e1012866
• Main Authors: Kochayoo, Piyawan, Moriyama, Saya, Kotaki, Ryutaro, Thawornpan, Pongsakorn, Malee, Chayapat, Leepiyasakulchai, Chaniya, Ntumngia, Francis Babila, Adams, John H., Takahashi, Yoshimasa, Chootong, Patchanee
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 23.01.2025; Public Library of Science (PLoS)
• Subjects: Antibodies; Antibodies, Neutralizing - immunology; Antibodies, Protozoan - immunology; Antigens, Protozoan - immunology; B cells; Biology and Life Sciences; Female; Health aspects; Humans; Immunoglobulin G - immunology; Malaria; Malaria, Vivax - immunology; Medical research; Medicine and Health Sciences; Medicine, Experimental; Memory B Cells - immunology; Physiological aspects; Plasmodium vivax; Plasmodium vivax - immunology; Protozoan Proteins - immunology; Receptors, Cell Surface; Research and Analysis Methods; Viral antibodies; Thailand

Expansion of atypical memory B cells (aMBCs) was demonstrated in malaria-exposed individuals. To date, the generation of P . vivax -specific aMBCs and their function in protective humoral immune responses is unknown. Here, P . vivax Duffy Binding Protein II (PvDBPII) probes were generated to detect...