MiR322 mediates cardioprotection against ischemia/reperfusion injury via FBXW7/notch pathway

• Published in: Journal of molecular and cellular cardiology Vol. 133; pp. 67 - 74
• Main Authors: Chen, Zixin, Su, Xuan, Shen, Yan, Jin, Yue, Luo, Tong, Kim, Il-man, Weintraub, Neal L., Tang, Yaoliang
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2019
• Subjects: 3' Untranslated Regions; Animals; Apoptosis; Cell Line; Disease Models, Animal; F-Box-WD Repeat-Containing Protein 7 - genetics; F-Box-WD Repeat-Containing Protein 7 - metabolism; FBXW7; Fluorescent Antibody Technique; Gene Expression Regulation; Ischemia; Mice; MicroRNAs - genetics; miR322; Myocardial Reperfusion Injury - etiology; Myocardial Reperfusion Injury - metabolism; Myocardial Reperfusion Injury - pathology; Myocytes, Cardiac - metabolism; Notch; Oxidative Stress; Receptors, Notch - metabolism; Reperfusion; RNA Interference; Signal Transduction; miR322; Reperfusion; Ischemia; FBXW7; Notch; Apoptosis

Myocardial ischemia/reperfusion (MI/R) causes loss of cardiomyocytes via oxidative stress-induced cardiomyocyte apoptosis. miR322, orthologous to human miR-424, was identified as an ischemia-induced angiogenic miRNA, but its cellular source and function in the setting of acute MI/R remains largely u...