Increased levels of 5′,8-Cyclopurine DNA lesions in inflammatory bowel diseases

• Published in: Redox biology Vol. 34; p. 101562
• Main Authors: Masi, Annalisa, Fortini, Paola, Krokidis, Marios G., Romeo, Erminia Francesca, Bascietto, Cinzia, De Angelis, Paola, Guglielmi, Valeria, Chatgilialoglu, Chryssostomos
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2020; Elsevier
• Subjects: Cyclopurines; DNA damage; Free radicals; Inflammatory bowel diseases; Obesity; Reactive oxygen species; Research Paper; Obesity; Reactive oxygen species; Inflammatory bowel diseases; Free radicals; DNA damage; Cyclopurines

Chronic inflammation is estimated to be a causative factor in a variety of diseases. Under inflammatory conditions reactive oxygen species (ROS) and nitrogen species (RNS) are released leading to DNA damage accumulation and genomic instability. Purine 5′,8-cyclo-2′-deoxynucleosides (cPu) are oxidati...