The Shrimp NF-κB Pathway Is Activated by White Spot Syndrome Virus (WSSV) 449 to Facilitate the Expression of WSSV069 (ie1), WSSV303 and WSSV371

• Published in: PloS one Vol. 6; no. 9; p. e24773
• Main Authors: Wang, Pei-Hui, Gu, Zhi-Hua, Wan, Ding-Hui, Zhang, Ming-Yan, Weng, Shao-Ping, Yu, Xiao-Qiang, He, Jian-Guo
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.09.2011; Public Library of Science (PLoS)
• Subjects: Agriculture; Animals; Apoptosis; Bacteria; Binding sites; Biology; Cell Line; Computational Biology; DNA, Complementary - genetics; Gene expression; Gene regulation; Genes; Genetic engineering; Genome, Insect - genetics; Genomes; IE1 protein; Immune system; Immunoprecipitation; Insects; Invertebrates; Kinases; Litopenaeus vannamei; Mammals; Medicine; Molecular structure; MyD88 protein; NF-kappa B - metabolism; NF-κB protein; Pathogens; Penaeidae - genetics; Penaeidae - metabolism; Penaeidae - virology; Promoters; Proteins; Real-Time Polymerase Chain Reaction; Signal transduction; Signal Transduction - genetics; Signal Transduction - physiology; Toll-like receptors; TRAF6 protein; Veterinary Science; Viruses; White spot syndrome; White spot syndrome virus 1 - physiology

The Toll-like receptor (TLR)-mediated NF-κB pathway is essential for defending against viruses in insects and mammals. Viruses also develop strategies to utilize this pathway to benefit their infection and replication in mammal hosts. In invertebrates, the TLR-mediated NF-κB pathway has only been we...