Buprenorphine Maintenance Subjects Are Hyperalgesic and Have No Antinociceptive Response to a Very High Morphine Dose

• Published in: Pain medicine (Malden, Mass.) Vol. 20; no. 1; pp. 119 - 128
• Main Authors: Athanasos, Peter, Ling, Walter, Bochner, Felix, White, Jason M, Somogyi, Andrew A
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.01.2019
• Subjects: Acute pain; Addiction; Adult; Analgesics, Opioid - administration & dosage; Analgesics, Opioid - therapeutic use; Blindness; Blood tests; Buprenorphine; Buprenorphine - administration & dosage; Buprenorphine - analogs & derivatives; Buprenorphine - therapeutic use; Clinical trials; Cold tolerance; Double-blind studies; Drug abuse; Drug Tolerance - physiology; Electrical stimuli; Female; Humans; Hyperalgesia; Hyperalgesia - chemically induced; Hyperalgesia - drug therapy; Injections, Intravenous - methods; Intravenous administration; Male; Methadone; Methadone - administration & dosage; Methadone - therapeutic use; Morphine; Morphine - administration & dosage; Morphine - therapeutic use; Narcotics; Opiate Substitution Treatment; Opioids; OPIOIDS & SUBSTANCE USE DISORDERS SECTION; Pain; Pain management; Pain Measurement - drug effects; Pain perception; Pain Threshold - drug effects; Respiration; Young Adult; Australia; Pain Medicine; Addiction; Opioids; Hyperalgesia

Abstract Objective Acute pain management in opioid-dependent persons is complicated because of tolerance and opioid-induced hyperalgesia. Very high doses of morphine are ineffective in overcoming opioid-induced hyperalgesia and providing antinociception to methadone-maintained patients in an experim...