Resilience to stress and sex-specific remodeling of microglia and neuronal morphology in a rat model of anxiety and anhedonia

• Published in: Neurobiology of stress Vol. 14; p. 100302
• Main Authors: Gaspar, Rita, Soares-Cunha, Carina, Domingues, Ana Verónica, Coimbra, Bárbara, Baptista, Filipa I., Pinto, Luísa, Ambrósio, António F., Rodrigues, Ana João, Gomes, Catarina A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2021; Elsevier
• Subjects: Chronic stress; Dorsal hippocampus; Microglia morphology; Nucleus accumbens; Original; Prenatal stress; Sex; Nucleus accumbens; Microglia morphology; Chronic stress; Sex; Prenatal stress; Dorsal hippocampus

Prenatal exposure to stress or glucocorticoids (GC) is associated with the appearance of psychiatric diseases later in life. Microglia, the immune cells of the brain, are altered in stress-related disorders. Synthetic GC such as dexamethasone (DEX) are commonly prescribed in case of preterm risk lab...