Differential effects of intermittent and continuous exposure to novel environmental stimuli on the development of amphetamine-induced behavioral sensitization in mice: Implications for addiction

• Published in: Drug and alcohol dependence Vol. 124; no. 1; pp. 135 - 141
• Main Authors: Fukushiro, Daniela F, Josino, Fabiana S, Saito, Luis P, Costa, Jacqueline M, Zanlorenci, Lineane H.F, Berro, Laís F, Fernandes-Santos, Luciano, Morgado, Fiorella, Mári-Kawamoto, Elisa, Frussa-Filho, Roberto
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.07.2012; Elsevier
• Subjects: Addictive behaviors; Adult and adolescent clinical studies; Amphetamine; Amphetamine - pharmacology; Animals; Behavior, Animal - drug effects; Behavioral sensitization; Biological and medical sciences; Central Nervous System Sensitization; Central Nervous System Stimulants - pharmacology; Drug abuse; Drug addiction; Environment; Intermittent; Locomotion; Locomotion - drug effects; Male; Medical sciences; Mice; Miscellaneous; Motor Activity - drug effects; Neuropharmacology; Novel objects; Open field; Pharmacology. Drug treatments; Psychiatry; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychopharmacology; Public health. Hygiene; Public health. Hygiene-occupational medicine; Sensitization; Social development; Treatment; Locomotion; Amphetamine; Open field; Behavioral sensitization; Novel objects; Amphetamine derivatives; Continuous; Psychotropic; Intermittent; Development; Amfetamine; Sensitization; Drug of abuse; Public health; Human; Drug addiction; CNS stimulant; Rodentia; Exposure; Novelty stimulus; Open field behavior; Vertebrata; Mammalia; Addiction; Mouse; Animal; Environment

Abstract Background Previous studies have demonstrated a preventive effect of continuous environmental enrichment during early development on the vulnerability of rodents to drug addiction-related behaviors. Recently, it was demonstrated that a continuous environmental enrichment could eliminate alr...