α-Synuclein amplifies cytoplasmic peroxide flux and oxidative stress provoked by mitochondrial inhibitors in CNS dopaminergic neurons in vivo
Convergent evidence implicates impaired mitochondrial function and α-Synuclein accumulation as critical upstream events in the pathogenesis of Parkinson's disease, but comparatively little is known about how these factors interact to provoke neurodegeneration. We previously showed that α-Synucl...
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Published in | Redox biology Vol. 37; p. 101695 |
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Abstract | Convergent evidence implicates impaired mitochondrial function and α-Synuclein accumulation as critical upstream events in the pathogenesis of Parkinson's disease, but comparatively little is known about how these factors interact to provoke neurodegeneration. We previously showed that α-Synuclein knockdown protected rat substantia nigra dopaminergic neurons from systemic exposure to the mitochondrial complex I inhibitor rotenone. Here we show that motor abnormalities prior to neuronal loss in this model are associated with extensive α-Synuclein-dependent cellular thiol oxidation. In order to elucidate the underlying events in vivo we constructed novel transgenic zebrafish that co-express, in dopaminergic neurons: (i) human α-Synuclein at levels insufficient to provoke neurodegeneration or neurobehavioral abnormalities; and (ii) genetically-encoded ratiometric fluorescent biosensors to detect cytoplasmic peroxide flux and glutathione oxidation. Live intravital imaging of the intact zebrafish CNS at cellular resolution showed unequivocally that α-Synuclein amplified dynamic cytoplasmic peroxide flux in dopaminergic neurons following exposure to the mitochondrial complex I inhibitors MPP+ or rotenone. This effect was robust and clearly evident following either acute or prolonged exposure to each inhibitor. In addition, disturbance of the resting glutathione redox potential following exogenous hydrogen peroxide challenge was augmented by α-Synuclein. Together these data show that α-Synuclein is a critical determinant of the redox consequences of mitochondrial dysfunction in dopaminergic neurons. The findings are important because the mechanisms underlying α-Synuclein-dependent reactive oxygen species fluxes and antioxidant suppression might provide a pharmacological target in Parkinson's disease to prevent progression from mitochondrial dysfunction and oxidative stress to cell death.
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•Extensive neuronal thiol oxidation in a rat PD model is α-Synuclein-dependent.•Peroxide flux and glutathione oxidation can be imaged in live transgenic zebrafish.•α-Synuclein amplifies cytosolic peroxide flux in dopaminergic neurons.•α-Synuclein exacerbates dynamic disturbances of the glutathione redox potential.•The underlying molecular mechanisms may provide therapeutic targets in PD. |
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AbstractList | Convergent evidence implicates impaired mitochondrial function and α-Synuclein accumulation as critical upstream events in the pathogenesis of Parkinson's disease, but comparatively little is known about how these factors interact to provoke neurodegeneration. We previously showed that α-Synuclein knockdown protected rat substantia nigra dopaminergic neurons from systemic exposure to the mitochondrial complex I inhibitor rotenone. Here we show that motor abnormalities prior to neuronal loss in this model are associated with extensive α-Synuclein-dependent cellular thiol oxidation. In order to elucidate the underlying events in vivo we constructed novel transgenic zebrafish that co-express, in dopaminergic neurons: (i) human α-Synuclein at levels insufficient to provoke neurodegeneration or neurobehavioral abnormalities; and (ii) genetically-encoded ratiometric fluorescent biosensors to detect cytoplasmic peroxide flux and glutathione oxidation. Live intravital imaging of the intact zebrafish CNS at cellular resolution showed unequivocally that α-Synuclein amplified dynamic cytoplasmic peroxide flux in dopaminergic neurons following exposure to the mitochondrial complex I inhibitors MPP+ or rotenone. This effect was robust and clearly evident following either acute or prolonged exposure to each inhibitor. In addition, disturbance of the resting glutathione redox potential following exogenous hydrogen peroxide challenge was augmented by α-Synuclein. Together these data show that α-Synuclein is a critical determinant of the redox consequences of mitochondrial dysfunction in dopaminergic neurons. The findings are important because the mechanisms underlying α-Synuclein-dependent reactive oxygen species fluxes and antioxidant suppression might provide a pharmacological target in Parkinson's disease to prevent progression from mitochondrial dysfunction and oxidative stress to cell death.
[Display omitted]
•Extensive neuronal thiol oxidation in a rat PD model is α-Synuclein-dependent.•Peroxide flux and glutathione oxidation can be imaged in live transgenic zebrafish.•α-Synuclein amplifies cytosolic peroxide flux in dopaminergic neurons.•α-Synuclein exacerbates dynamic disturbances of the glutathione redox potential.•The underlying molecular mechanisms may provide therapeutic targets in PD. Convergent evidence implicates impaired mitochondrial function and α-Synuclein accumulation as critical upstream events in the pathogenesis of Parkinson's disease, but comparatively little is known about how these factors interact to provoke neurodegeneration. We previously showed that α-Synuclein knockdown protected rat substantia nigra dopaminergic neurons from systemic exposure to the mitochondrial complex I inhibitor rotenone. Here we show that motor abnormalities prior to neuronal loss in this model are associated with extensive α-Synuclein-dependent cellular thiol oxidation. In order to elucidate the underlying events in vivo we constructed novel transgenic zebrafish that co-express, in dopaminergic neurons: (i) human α-Synuclein at levels insufficient to provoke neurodegeneration or neurobehavioral abnormalities; and (ii) genetically-encoded ratiometric fluorescent biosensors to detect cytoplasmic peroxide flux and glutathione oxidation. Live intravital imaging of the intact zebrafish CNS at cellular resolution showed unequivocally that α-Synuclein amplified dynamic cytoplasmic peroxide flux in dopaminergic neurons following exposure to the mitochondrial complex I inhibitors MPP or rotenone. This effect was robust and clearly evident following either acute or prolonged exposure to each inhibitor. In addition, disturbance of the resting glutathione redox potential following exogenous hydrogen peroxide challenge was augmented by α-Synuclein. Together these data show that α-Synuclein is a critical determinant of the redox consequences of mitochondrial dysfunction in dopaminergic neurons. The findings are important because the mechanisms underlying α-Synuclein-dependent reactive oxygen species fluxes and antioxidant suppression might provide a pharmacological target in Parkinson's disease to prevent progression from mitochondrial dysfunction and oxidative stress to cell death. Convergent evidence implicates impaired mitochondrial function and α-Synuclein accumulation as critical upstream events in the pathogenesis of Parkinson's disease, but comparatively little is known about how these factors interact to provoke neurodegeneration. We previously showed that α-Synuclein knockdown protected rat substantia nigra dopaminergic neurons from systemic exposure to the mitochondrial complex I inhibitor rotenone. Here we show that motor abnormalities prior to neuronal loss in this model are associated with extensive α-Synuclein-dependent cellular thiol oxidation. In order to elucidate the underlying events in vivo we constructed novel transgenic zebrafish that co-express, in dopaminergic neurons: (i) human α-Synuclein at levels insufficient to provoke neurodegeneration or neurobehavioral abnormalities; and (ii) genetically-encoded ratiometric fluorescent biosensors to detect cytoplasmic peroxide flux and glutathione oxidation. Live intravital imaging of the intact zebrafish CNS at cellular resolution showed unequivocally that α-Synuclein amplified dynamic cytoplasmic peroxide flux in dopaminergic neurons following exposure to the mitochondrial complex I inhibitors MPP+ or rotenone. This effect was robust and clearly evident following either acute or prolonged exposure to each inhibitor. In addition, disturbance of the resting glutathione redox potential following exogenous hydrogen peroxide challenge was augmented by α-Synuclein. Together these data show that α-Synuclein is a critical determinant of the redox consequences of mitochondrial dysfunction in dopaminergic neurons. The findings are important because the mechanisms underlying α-Synuclein-dependent reactive oxygen species fluxes and antioxidant suppression might provide a pharmacological target in Parkinson's disease to prevent progression from mitochondrial dysfunction and oxidative stress to cell death. Convergent evidence implicates impaired mitochondrial function and α-Synuclein accumulation as critical upstream events in the pathogenesis of Parkinson's disease, but comparatively little is known about how these factors interact to provoke neurodegeneration. We previously showed that α-Synuclein knockdown protected rat substantia nigra dopaminergic neurons from systemic exposure to the mitochondrial complex I inhibitor rotenone. Here we show that motor abnormalities prior to neuronal loss in this model are associated with extensive α-Synuclein-dependent cellular thiol oxidation. In order to elucidate the underlying events in vivo we constructed novel transgenic zebrafish that co-express, in dopaminergic neurons: (i) human α-Synuclein at levels insufficient to provoke neurodegeneration or neurobehavioral abnormalities; and (ii) genetically-encoded ratiometric fluorescent biosensors to detect cytoplasmic peroxide flux and glutathione oxidation. Live intravital imaging of the intact zebrafish CNS at cellular resolution showed unequivocally that α-Synuclein amplified dynamic cytoplasmic peroxide flux in dopaminergic neurons following exposure to the mitochondrial complex I inhibitors MPP + or rotenone. This effect was robust and clearly evident following either acute or prolonged exposure to each inhibitor. In addition, disturbance of the resting glutathione redox potential following exogenous hydrogen peroxide challenge was augmented by α-Synuclein. Together these data show that α-Synuclein is a critical determinant of the redox consequences of mitochondrial dysfunction in dopaminergic neurons. The findings are important because the mechanisms underlying α-Synuclein-dependent reactive oxygen species fluxes and antioxidant suppression might provide a pharmacological target in Parkinson's disease to prevent progression from mitochondrial dysfunction and oxidative stress to cell death. Image 1 • Extensive neuronal thiol oxidation in a rat PD model is α-Synuclein-dependent. • Peroxide flux and glutathione oxidation can be imaged in live transgenic zebrafish. • α-Synuclein amplifies cytosolic peroxide flux in dopaminergic neurons. • α-Synuclein exacerbates dynamic disturbances of the glutathione redox potential. • The underlying molecular mechanisms may provide therapeutic targets in PD. |
ArticleNumber | 101695 |
Author | Zharikov, Alevtina D. Dukes, April A. Greenamyre, J. Timothy Hastings, Teresa G. St Croix, Claudette M. Van Laar, Victor S. Chen, Jianming Burton, Edward A. Bai, Qing Watkins, Simon C. Di Maio, Roberto |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32905883$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1016/j.neulet.2008.05.005 10.1016/j.nbd.2009.01.016 10.1038/ng0298-106 10.1016/j.nbd.2009.03.004 10.1073/pnas.93.5.1956 10.1002/cne.23938 10.1016/j.neulet.2008.12.053 10.1038/nmeth.1212 10.1083/jcb.200809125 10.1084/jem.20112457 10.1007/s10863-009-9257-z 10.1523/JNEUROSCI.1638-12.2012 10.1016/S0006-8993(00)03174-7 10.1074/jbc.M800426200 10.1074/jbc.M606702200 10.1523/JNEUROSCI.23-34-10756.2003 10.1089/ars.2010.3629 10.1038/nprot.2014.094 10.1016/j.ydbio.2011.01.023 10.1016/j.neurobiolaging.2015.03.015 10.1074/jbc.M113.545749 10.1371/journal.pbio.1000298 10.1073/pnas.0705904104 10.1074/jbc.M111.308312 10.1126/science.aaf3934 10.1002/ana.410360305 10.1016/S0197-4580(02)00065-9 10.1089/ars.2009.2948 10.1126/science.1090278 10.1016/j.freeradbiomed.2013.06.030 10.1016/j.freeradbiomed.2016.04.001 10.1074/jbc.M102124200 10.1002/dvdy.21569 10.1074/jbc.M113.545301 10.1016/j.nbd.2011.05.016 10.1172/JCI64502 10.1186/1750-1326-6-8 10.1186/s12974-016-0606-7 10.1016/0304-3940(82)90390-1 10.1186/s40478-015-0189-z 10.1016/0304-3940(85)90078-3 10.1289/ehp.1002839 10.1016/j.nbd.2019.01.004 10.1126/scitranslmed.aaf3634 10.1038/42166 10.1016/S0140-6736(04)17103-1 10.1038/ng.487 10.1016/j.yexcr.2008.03.012 10.1074/jbc.M109.059246 10.1016/j.nbd.2016.07.020 10.1002/mds.27383 10.1016/S0140-6736(89)92366-0 10.7554/eLife.51845 10.1089/ars.2011.3960 10.1111/j.1471-4159.1991.tb11409.x 10.1016/j.stem.2007.11.002 10.1002/ana.410370604 10.1016/j.redox.2017.11.010 10.1002/dvg.20338 10.1073/pnas.82.7.2173 10.4161/cbt.4.12.2233 10.1073/pnas.0937239100 10.1074/jbc.M710012200 10.1126/science.6823561 10.1038/81834 10.1038/ng.485 10.1016/j.pharmthera.2010.01.003 10.1016/j.expneurol.2008.02.024 10.1097/WNR.0b013e3282f03db4 10.1126/science.276.5321.2045 10.1074/jbc.M001914200 10.1523/JNEUROSCI.2246-12.2012 10.1007/BF01291884 10.1006/exnr.2002.8072 10.1113/jphysiol.2011.207308 |
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Keywords | α-Synuclein Zebrafish Dopaminergic neuron Parkinson's disease Peroxide Glutathione |
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References | Lambert, Bonkowsky, Masino (bib35) 2012; 32 Di Maio, Barrett, Hoffman, Barrett, Zharikov, Borah, Hu, McCoy, Chu, Burton (bib17) 2016; 8 Chandel, McClintock, Feliciano, Wood, Melendez, Rodriguez, Schumacker (bib10) 2000; 275 Narendra, Tanaka, Suen, Youle (bib46) 2008; 183 Blackinton, Kumaran, van der Brug, Ahmad, Olson, Galter, Lees, Bandopadhyay, Cookson (bib5) 2009; 452 Gutscher, Sobotta, Wabnitz, Ballikaya, Meyer, Samstag, Dick (bib23) 2009; 284 Betarbet, Sherer, MacKenzie, Garcia-Osuna, Panov, Greenamyre (bib4) 2000; 3 Polymeropoulos, Lavedan, Leroy, Ide, Dehejia, Dutra, Pike, Root, Rubenstein, Boyer (bib50) 1997; 276 Dukes, Bai, Van Laar, Zhou, Ilin, David, Agim, Bonkowsky, Cannon, Watkins (bib18) 2016; 95 Singleton, Farrer, Johnson, Singleton, Hague, Kachergus, Hulihan, Peuralinna, Dutra, Nussbaum (bib62) 2003; 302 Hou, Bao, Zang, Yang, Sun, Che, Wu, Li, Zhang, Wang (bib29) 2018; 14 Sherer, Kim, Betarbet, Greenamyre (bib59) 2003; 179 Van Laar, Mishizen, Cascio, Hastings (bib66) 2009; 34 Narendra, Jin, Tanaka, Suen, Gautier, Shen, Cookson, Youle (bib47) 2010; 8 Quinlan, Goncalves, Hey-Mogensen, Yadava, Bunik, Brand (bib52) 2014; 289 Sian, Dexter, Lees, Daniel, Agid, Javoy-Agid, Jenner, Marsden (bib60) 1994; 36 Hastings (bib25) 2009; 41 Milanese, Sager, Bai, Farrell, Cannon, Greenamyre, Burton (bib44) 2012; 287 Zhou, Cattley, Cario, Bai, Burton (bib77) 2014; 9 Simon-Sanchez, Schulte, Bras, Sharma, Gibbs, Berg, Paisan-Ruiz, Lichtner, Scholz, Hernandez (bib61) 2009; 41 Devi, Raghavendran, Prabhu, Avadhani, Anandatheerthavarada (bib16) 2008; 283 Sun, Gitler (bib64) 2008; 237 Desouki, Kulawiec, Bansal, Das, Singh (bib15) 2005; 4 Fujimoto, Stevenson, Chien, Bonkowsky (bib21) 2011; 352 Li, Yang, Guo, Ren, Zha, Cheng, Cai (bib40) 2007; 18 Zharikov, Cannon, Tapias, Bai, Horowitz, Shah, El Ayadi, Hastings, Greenamyre, Burton (bib76) 2015; 125 Cristovao, Guhathakurta, Bok, Je, Yoo, Choi, Kim (bib14) 2012; 32 Cole, Dieuliis, Leo, Mitchell, Nussbaum (bib13) 2008; 314 Shavali, Brown-Borg, Ebadi, Porter (bib57) 2008; 439 Kruger, Kuhn, Muller, Woitalla, Graeber, Kosel, Przuntek, Epplen, Schols, Riess (bib34) 1998; 18 Lee, Bae, Bae, Um (bib37) 2006; 281 Luk, Kehm, Zhang, O'Brien, Trojanowski, Lee (bib41) 2012; 209 Wang, Chu, Guo, Jiang, Nie, Zhang, Wilson, Yang, Stewart, Hong (bib67) 2016; 13 Cannon, Tapias, Na, Honick, Drolet, Greenamyre (bib8) 2009; 34 Cario, Farrell, Milanese, Burton (bib9) 2011; 589 Rink, Wullimann (bib54) 2001; 889 Wu, Teismann, Tieu, Vila, Jackson-Lewis, Ischiropoulos, Przedborski (bib72) 2003; 100 Meyer, Dick (bib43) 2010; 13 Javitch, D'Amato, Strittmatter, Snyder (bib30) 1985; 82 Pearce, Owen, Daniel, Jenner, Marsden (bib48) 1997; 104 Lee, Park, Shin, Hwang, Park, Park, Lee, Chae, Jin, Oh (bib38) 2008; 283 Tanner, Kamel, Ross, Hoppin, Goldman, Korell, Marras, Bhudhikanok, Kasten, Chade (bib65) 2011; 119 Fang, Nakamura, Cho, Gu, Lipton (bib19) 2007; 104 Langston, Ballard, Tetrud, Irwin (bib36) 1983; 219 Luth, Stavrovskaya, Bartels, Kristal, Selkoe (bib42) 2014; 289 Horowitz, Milanese, Di Maio, Hu, Montero, Sanders, Tapias, Sepe, van Cappellen, Burton (bib28) 2011; 15 Provost, Rhee, Leach (bib51) 2007; 45 Sherer, Betarbet, Testa, Seo, Richardson, Kim, Miller, Yagi, Matsuno-Yagi, Greenamyre (bib58) 2003; 23 Hauser, Dukes, Mortimer, Hastings (bib27) 2013; 65 Wilcox (bib70) 2010; 126 Xie, Jiao, Bai, Ilin, Sun, Burton, Kolodieznyi, Calderon, Stolz, Opresko (bib73) 2020; 9 Gutscher, Pauleau, Marty, Brach, Wabnitz, Samstag, Meyer, Dick (bib22) 2008; 5 Li, Miller, Zhang, Spitz, Oberley, Weintraub (bib39) 2001; 276 Bartel, Van Laar, Burton (bib2) 2020 Haas, Nasirian, Nakano, Ward, Pay, Hill, Shults (bib24) 1995; 37 Kish, Morito, Hornykiewicz (bib32) 1985; 58 Spillantini, Schmidt, Lee, Trojanowski, Jakes, Goedert (bib63) 1997; 388 Kordower, Burke (bib33) 2018; 33 Hastings, Lewis, Zigmond (bib26) 1996; 93 Choi, Cristovao, Guhathakurta, Lee, Joh, Beal, Kim (bib12) 2012; 16 Bellinger, Bellinger, Seale, Takemoto, Raman, Miki, Manning-Bog, Berry, White, Ross (bib3) 2011; 6 Mittal, Bjornevik, Im, Flierl, Dong, Locascio, Abo, Long, Jin, Xu (bib45) 2017; 357 Woodlee, Kane, Chang, Cormack, Schallert (bib71) 2008; 211 Satake, Nakabayashi, Mizuta, Hirota, Ito, Kubo, Kawaguchi, Tsunoda, Watanabe, Takeda (bib55) 2009; 41 Farrell, Cario, Milanese, Vogt, Jeong, Burton (bib20) 2011; 44 White, Sessa, Burke, Bowman, LeBlanc, Ceol, Bourque, Dovey, Goessling, Burns (bib69) 2008; 2 Braak, Del Tredici, Rub, de Vos, Jansen Steur, Braak (bib6) 2003; 24 Baba, Nakajo, Tu, Tomita, Nakaya, Lee, Trojanowski, Iwatsubo (bib1) 1998; 152 Schapira, Cooper, Dexter, Jenner, Clark, Marsden (bib56) 1989; 1 Ramsay, Krueger, Youngster, Gluck, Casida, Singer (bib53) 1991; 56 Jiang, Hoekstra, Heng, Kang, Ding, Liu, Chen, Zhang (bib31) 2015; 36 Zawada, Mrak, Biedermann, Palmer, Gentleman, Aboud, Griffin (bib74) 2015; 3 Brand (bib7) 2016; 100 Chartier-Harlin, Kachergus, Roumier, Mouroux, Douay, Lincoln, Levecque, Larvor, Andrieux, Hulihan (bib11) 2004; 364 Perry, Godin, Hansen (bib49) 1982; 33 Weaver, Leung, Suter (bib68) 2016; 524 Zharikov, Bai, De Miranda, Van Laar, Greenamyre, Burton (bib75) 2019; 125 Lee (10.1016/j.redox.2020.101695_bib38) 2008; 283 Blackinton (10.1016/j.redox.2020.101695_bib5) 2009; 452 Lee (10.1016/j.redox.2020.101695_bib37) 2006; 281 Pearce (10.1016/j.redox.2020.101695_bib48) 1997; 104 Lambert (10.1016/j.redox.2020.101695_bib35) 2012; 32 Zhou (10.1016/j.redox.2020.101695_bib77) 2014; 9 Wu (10.1016/j.redox.2020.101695_bib72) 2003; 100 Zharikov (10.1016/j.redox.2020.101695_bib75) 2019; 125 Kruger (10.1016/j.redox.2020.101695_bib34) 1998; 18 Desouki (10.1016/j.redox.2020.101695_bib15) 2005; 4 Wang (10.1016/j.redox.2020.101695_bib67) 2016; 13 Bellinger (10.1016/j.redox.2020.101695_bib3) 2011; 6 Kordower (10.1016/j.redox.2020.101695_bib33) 2018; 33 Rink (10.1016/j.redox.2020.101695_bib54) 2001; 889 Shavali (10.1016/j.redox.2020.101695_bib57) 2008; 439 Zawada (10.1016/j.redox.2020.101695_bib74) 2015; 3 Cario (10.1016/j.redox.2020.101695_bib9) 2011; 589 Singleton (10.1016/j.redox.2020.101695_bib62) 2003; 302 Devi (10.1016/j.redox.2020.101695_bib16) 2008; 283 Farrell (10.1016/j.redox.2020.101695_bib20) 2011; 44 Langston (10.1016/j.redox.2020.101695_bib36) 1983; 219 Braak (10.1016/j.redox.2020.101695_bib6) 2003; 24 Narendra (10.1016/j.redox.2020.101695_bib47) 2010; 8 Weaver (10.1016/j.redox.2020.101695_bib68) 2016; 524 Schapira (10.1016/j.redox.2020.101695_bib56) 1989; 1 Cole (10.1016/j.redox.2020.101695_bib13) 2008; 314 Cristovao (10.1016/j.redox.2020.101695_bib14) 2012; 32 Meyer (10.1016/j.redox.2020.101695_bib43) 2010; 13 Kish (10.1016/j.redox.2020.101695_bib32) 1985; 58 Luk (10.1016/j.redox.2020.101695_bib41) 2012; 209 Brand (10.1016/j.redox.2020.101695_bib7) 2016; 100 Gutscher (10.1016/j.redox.2020.101695_bib22) 2008; 5 Horowitz (10.1016/j.redox.2020.101695_bib28) 2011; 15 Sherer (10.1016/j.redox.2020.101695_bib59) 2003; 179 Sian (10.1016/j.redox.2020.101695_bib60) 1994; 36 Hastings (10.1016/j.redox.2020.101695_bib26) 1996; 93 Li (10.1016/j.redox.2020.101695_bib40) 2007; 18 Hauser (10.1016/j.redox.2020.101695_bib27) 2013; 65 Simon-Sanchez (10.1016/j.redox.2020.101695_bib61) 2009; 41 Narendra (10.1016/j.redox.2020.101695_bib46) 2008; 183 Spillantini (10.1016/j.redox.2020.101695_bib63) 1997; 388 Javitch (10.1016/j.redox.2020.101695_bib30) 1985; 82 Sherer (10.1016/j.redox.2020.101695_bib58) 2003; 23 Mittal (10.1016/j.redox.2020.101695_bib45) 2017; 357 Sun (10.1016/j.redox.2020.101695_bib64) 2008; 237 Fujimoto (10.1016/j.redox.2020.101695_bib21) 2011; 352 Chartier-Harlin (10.1016/j.redox.2020.101695_bib11) 2004; 364 Ramsay (10.1016/j.redox.2020.101695_bib53) 1991; 56 Di Maio (10.1016/j.redox.2020.101695_bib17) 2016; 8 Fang (10.1016/j.redox.2020.101695_bib19) 2007; 104 Wilcox (10.1016/j.redox.2020.101695_bib70) 2010; 126 Perry (10.1016/j.redox.2020.101695_bib49) 1982; 33 Gutscher (10.1016/j.redox.2020.101695_bib23) 2009; 284 Dukes (10.1016/j.redox.2020.101695_bib18) 2016; 95 Hou (10.1016/j.redox.2020.101695_bib29) 2018; 14 Tanner (10.1016/j.redox.2020.101695_bib65) 2011; 119 Hastings (10.1016/j.redox.2020.101695_bib25) 2009; 41 Woodlee (10.1016/j.redox.2020.101695_bib71) 2008; 211 Haas (10.1016/j.redox.2020.101695_bib24) 1995; 37 Li (10.1016/j.redox.2020.101695_bib39) 2001; 276 Milanese (10.1016/j.redox.2020.101695_bib44) 2012; 287 Choi (10.1016/j.redox.2020.101695_bib12) 2012; 16 Jiang (10.1016/j.redox.2020.101695_bib31) 2015; 36 Luth (10.1016/j.redox.2020.101695_bib42) 2014; 289 Xie (10.1016/j.redox.2020.101695_bib73) 2020; 9 Chandel (10.1016/j.redox.2020.101695_bib10) 2000; 275 Cannon (10.1016/j.redox.2020.101695_bib8) 2009; 34 Satake (10.1016/j.redox.2020.101695_bib55) 2009; 41 Van Laar (10.1016/j.redox.2020.101695_bib66) 2009; 34 Bartel (10.1016/j.redox.2020.101695_bib2) 2020 White (10.1016/j.redox.2020.101695_bib69) 2008; 2 Zharikov (10.1016/j.redox.2020.101695_bib76) 2015; 125 Betarbet (10.1016/j.redox.2020.101695_bib4) 2000; 3 Baba (10.1016/j.redox.2020.101695_bib1) 1998; 152 Provost (10.1016/j.redox.2020.101695_bib51) 2007; 45 Polymeropoulos (10.1016/j.redox.2020.101695_bib50) 1997; 276 Quinlan (10.1016/j.redox.2020.101695_bib52) 2014; 289 |
References_xml | – volume: 33 start-page: 305 year: 1982 end-page: 310 ident: bib49 article-title: Parkinson's disease: a disorder due to nigral glutathione deficiency? publication-title: Neurosci. Lett. contributor: fullname: Hansen – volume: 44 start-page: 9 year: 2011 end-page: 18 ident: bib20 article-title: Evaluation of spontaneous propulsive movement as a screening tool to detect rescue of Parkinsonism phenotypes in zebrafish models publication-title: Neurobiol. Dis. contributor: fullname: Burton – volume: 284 start-page: 31532 year: 2009 end-page: 31540 ident: bib23 article-title: Proximity-based protein thiol oxidation by H2O2-scavenging peroxidases publication-title: J. Biol. Chem. contributor: fullname: Dick – volume: 209 start-page: 975 year: 2012 end-page: 986 ident: bib41 article-title: Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice publication-title: J. Exp. Med. contributor: fullname: Lee – volume: 36 start-page: 2304 year: 2015 end-page: 2318 ident: bib31 article-title: P2X7 receptor is critical in alpha-synuclein--mediated microglial NADPH oxidase activation publication-title: Neurobiol. Aging contributor: fullname: Zhang – volume: 183 start-page: 795 year: 2008 end-page: 803 ident: bib46 article-title: Parkin is recruited selectively to impaired mitochondria and promotes their autophagy publication-title: J. Cell Biol. contributor: fullname: Youle – volume: 8 start-page: 342ra378 year: 2016 ident: bib17 article-title: alpha-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease publication-title: Sci. Transl. Med. contributor: fullname: Burton – volume: 388 start-page: 839 year: 1997 end-page: 840 ident: bib63 article-title: Alpha-synuclein in Lewy bodies publication-title: Nature contributor: fullname: Goedert – volume: 219 start-page: 979 year: 1983 end-page: 980 ident: bib36 article-title: Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis publication-title: Science contributor: fullname: Irwin – volume: 452 start-page: 8 year: 2009 end-page: 11 ident: bib5 article-title: Post-transcriptional regulation of mRNA associated with DJ-1 in sporadic Parkinson disease publication-title: Neurosci. Lett. contributor: fullname: Cookson – volume: 34 start-page: 279 year: 2009 end-page: 290 ident: bib8 article-title: A highly reproducible rotenone model of Parkinson's disease publication-title: Neurobiol. Dis. contributor: fullname: Greenamyre – volume: 32 start-page: 14465 year: 2012 end-page: 14477 ident: bib14 article-title: NADPH oxidase 1 mediates alpha-synucleinopathy in Parkinson's disease publication-title: J. Neurosci. contributor: fullname: Kim – volume: 82 start-page: 2173 year: 1985 end-page: 2177 ident: bib30 article-title: Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Snyder – volume: 32 start-page: 13488 year: 2012 end-page: 13500 ident: bib35 article-title: The conserved dopaminergic diencephalospinal tract mediates vertebrate locomotor development in zebrafish larvae publication-title: J. Neurosci. contributor: fullname: Masino – volume: 1 start-page: 1269 year: 1989 ident: bib56 article-title: Mitochondrial complex I deficiency in Parkinson's disease publication-title: Lancet contributor: fullname: Marsden – volume: 314 start-page: 2076 year: 2008 end-page: 2089 ident: bib13 article-title: Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification publication-title: Exp. Cell Res. contributor: fullname: Nussbaum – volume: 283 start-page: 9986 year: 2008 end-page: 9998 ident: bib38 article-title: Oxidative modification of peroxiredoxin is associated with drug-induced apoptotic signaling in experimental models of Parkinson disease publication-title: J. Biol. Chem. contributor: fullname: Oh – volume: 58 start-page: 343 year: 1985 end-page: 346 ident: bib32 article-title: Glutathione peroxidase activity in Parkinson's disease brain publication-title: Neurosci. Lett. contributor: fullname: Hornykiewicz – volume: 119 start-page: 866 year: 2011 end-page: 872 ident: bib65 article-title: Rotenone, paraquat, and Parkinson's disease publication-title: Environ. Health Perspect. contributor: fullname: Chade – volume: 100 start-page: 6145 year: 2003 end-page: 6150 ident: bib72 article-title: NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Przedborski – volume: 45 start-page: 625 year: 2007 end-page: 629 ident: bib51 article-title: Viral 2A peptides allow expression of multiple proteins from a single ORF in transgenic zebrafish embryos publication-title: Genesis contributor: fullname: Leach – volume: 276 start-page: 2045 year: 1997 end-page: 2047 ident: bib50 article-title: Mutation in the alpha-synuclein gene identified in families with Parkinson's disease publication-title: Science contributor: fullname: Boyer – volume: 14 start-page: 600 year: 2018 end-page: 608 ident: bib29 article-title: Integrin CD11b mediates alpha-synuclein-induced activation of NADPH oxidase through a Rho-dependent pathway publication-title: Redox Biol contributor: fullname: Wang – volume: 4 start-page: 1367 year: 2005 end-page: 1373 ident: bib15 article-title: Cross talk between mitochondria and superoxide generating NADPH oxidase in breast and ovarian tumors publication-title: Canc. Biol. Ther. contributor: fullname: Singh – volume: 2 start-page: 183 year: 2008 end-page: 189 ident: bib69 article-title: Transparent adult zebrafish as a tool for in vivo transplantation analysis publication-title: Cell Stem Cell contributor: fullname: Burns – volume: 18 start-page: 106 year: 1998 end-page: 108 ident: bib34 article-title: Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease publication-title: Nat. Genet. contributor: fullname: Riess – volume: 125 start-page: 2721 year: 2015 end-page: 2735 ident: bib76 article-title: shRNA targeting alpha-synuclein prevents neurodegeneration in a Parkinson's disease model publication-title: J. Clin. Invest. contributor: fullname: Burton – volume: 289 start-page: 8312 year: 2014 end-page: 8325 ident: bib52 article-title: The 2-oxoacid dehydrogenase complexes in mitochondria can produce superoxide/hydrogen peroxide at much higher rates than complex I publication-title: J. Biol. Chem. contributor: fullname: Brand – volume: 41 start-page: 1308 year: 2009 end-page: 1312 ident: bib61 article-title: Genome-wide association study reveals genetic risk underlying Parkinson's disease publication-title: Nat. Genet. contributor: fullname: Hernandez – volume: 41 start-page: 1303 year: 2009 end-page: 1307 ident: bib55 article-title: Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease publication-title: Nat. Genet. contributor: fullname: Takeda – volume: 352 start-page: 393 year: 2011 end-page: 404 ident: bib21 article-title: Identification of a dopaminergic enhancer indicates complexity in vertebrate dopamine neuron phenotype specification publication-title: Dev. Biol. contributor: fullname: Bonkowsky – volume: 889 start-page: 316 year: 2001 end-page: 330 ident: bib54 article-title: The teleostean (zebrafish) dopaminergic system ascending to the subpallium (striatum) is located in the basal diencephalon (posterior tuberculum) publication-title: Brain Res. contributor: fullname: Wullimann – volume: 125 start-page: 146 year: 2019 end-page: 153 ident: bib75 article-title: Long-term RNAi knockdown of alpha-synuclein in the adult rat substantia nigra without neurodegeneration publication-title: Neurobiol. Dis. contributor: fullname: Burton – volume: 276 start-page: 29251 year: 2001 end-page: 29256 ident: bib39 article-title: H(2)O(2)-induced O(2) production by a non-phagocytic NAD(P)H oxidase causes oxidant injury publication-title: J. Biol. Chem. contributor: fullname: Weintraub – volume: 100 start-page: 14 year: 2016 end-page: 31 ident: bib7 article-title: Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling publication-title: Free Radic. Biol. Med. contributor: fullname: Brand – volume: 152 start-page: 879 year: 1998 end-page: 884 ident: bib1 article-title: Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies publication-title: Am. J. Pathol. contributor: fullname: Iwatsubo – volume: 439 start-page: 125 year: 2008 end-page: 128 ident: bib57 article-title: Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells publication-title: Neurosci. Lett. contributor: fullname: Porter – volume: 9 year: 2020 ident: bib73 article-title: Chemoptogenetic ablation of neuronal mitochondria in vivo with spatiotemporal precision and controllable severity publication-title: eLife contributor: fullname: Opresko – volume: 13 start-page: 621 year: 2010 end-page: 650 ident: bib43 article-title: Fluorescent protein-based redox probes publication-title: Antioxidants Redox Signal. contributor: fullname: Dick – volume: 211 start-page: 511 year: 2008 end-page: 517 ident: bib71 article-title: Enhanced function in the good forelimb of hemi-Parkinson rats: compensatory adaptation for contralateral postural instability? publication-title: Exp. Neurol. contributor: fullname: Schallert – volume: 16 start-page: 1033 year: 2012 end-page: 1045 ident: bib12 article-title: NADPH oxidase 1-mediated oxidative stress leads to dopamine neuron death in Parkinson's disease publication-title: Antioxidants Redox Signal. contributor: fullname: Kim – volume: 289 start-page: 21490 year: 2014 end-page: 21507 ident: bib42 article-title: Soluble, prefibrillar alpha-synuclein oligomers promote complex I-dependent, Ca2+-induced mitochondrial dysfunction publication-title: J. Biol. Chem. contributor: fullname: Selkoe – volume: 104 start-page: 661 year: 1997 end-page: 677 ident: bib48 article-title: Alterations in the distribution of glutathione in the substantia nigra in Parkinson's disease publication-title: J. Neural. Transm. contributor: fullname: Marsden – volume: 36 start-page: 348 year: 1994 end-page: 355 ident: bib60 article-title: Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia publication-title: Ann. Neurol. contributor: fullname: Marsden – volume: 24 start-page: 197 year: 2003 end-page: 211 ident: bib6 article-title: Staging of brain pathology related to sporadic Parkinson's disease publication-title: Neurobiol. Aging contributor: fullname: Braak – volume: 41 start-page: 469 year: 2009 end-page: 472 ident: bib25 article-title: The role of dopamine oxidation in mitochondrial dysfunction: implications for Parkinson's disease publication-title: J. Bioenerg. Biomembr. contributor: fullname: Hastings – volume: 13 start-page: 158 year: 2016 ident: bib67 article-title: Identification of a specific alpha-synuclein peptide (alpha-Syn 29-40) capable of eliciting microglial superoxide production to damage dopaminergic neurons publication-title: J. Neuroinflammation contributor: fullname: Hong – volume: 237 start-page: 2490 year: 2008 end-page: 2495 ident: bib64 article-title: Discovery and characterization of three novel synuclein genes in zebrafish publication-title: Dev. Dynam. contributor: fullname: Gitler – volume: 126 start-page: 119 year: 2010 end-page: 145 ident: bib70 article-title: Effects of tempol and redox-cycling nitroxides in models of oxidative stress publication-title: Pharmacol. Ther. contributor: fullname: Wilcox – volume: 3 start-page: 1301 year: 2000 end-page: 1306 ident: bib4 article-title: Chronic systemic pesticide exposure reproduces features of Parkinson's disease publication-title: Nat. Neurosci. contributor: fullname: Greenamyre – volume: 3 start-page: 9 year: 2015 ident: bib74 article-title: Loss of angiotensin II receptor expression in dopamine neurons in Parkinson's disease correlates with pathological progression and is accompanied by increases in Nox4- and 8-OH guanosine-related nucleic acid oxidation and caspase-3 activation publication-title: Acta Neuropathologica Commun. contributor: fullname: Griffin – volume: 275 start-page: 25130 year: 2000 end-page: 25138 ident: bib10 article-title: Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1 alpha during hypoxia: a mechanism of O2 sensing publication-title: J. Biol. Chem. contributor: fullname: Schumacker – volume: 65 start-page: 419 year: 2013 end-page: 427 ident: bib27 article-title: Dopamine quinone modifies and decreases the abundance of the mitochondrial selenoprotein glutathione peroxidase 4 publication-title: Free Radic. Biol. Med. contributor: fullname: Hastings – volume: 179 start-page: 9 year: 2003 end-page: 16 ident: bib59 article-title: Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation publication-title: Exp. Neurol. contributor: fullname: Greenamyre – volume: 283 start-page: 9089 year: 2008 end-page: 9100 ident: bib16 article-title: Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain publication-title: J. Biol. Chem. contributor: fullname: Anandatheerthavarada – volume: 357 start-page: 891 year: 2017 end-page: 898 ident: bib45 article-title: beta2-Adrenoreceptor is a regulator of the alpha-synuclein gene driving risk of Parkinson's disease publication-title: Science contributor: fullname: Xu – start-page: 377 year: 2020 end-page: 412 ident: bib2 article-title: Parkinson's disease publication-title: Behavioral and Neural Genetics of Zebrafish contributor: fullname: Burton – volume: 33 start-page: 678 year: 2018 end-page: 683 ident: bib33 article-title: Disease modification for Parkinson's disease: axonal regeneration and trophic factors publication-title: Mov. Disord. contributor: fullname: Burke – volume: 93 start-page: 1956 year: 1996 end-page: 1961 ident: bib26 article-title: Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Zigmond – volume: 5 start-page: 553 year: 2008 end-page: 559 ident: bib22 article-title: Real-time imaging of the intracellular glutathione redox potential publication-title: Nat. Methods contributor: fullname: Dick – volume: 37 start-page: 714 year: 1995 end-page: 722 ident: bib24 article-title: Low platelet mitochondrial complex I and complex II/III activity in early untreated Parkinson's disease publication-title: Ann. Neurol. contributor: fullname: Shults – volume: 9 start-page: 1533 year: 2014 end-page: 1548 ident: bib77 article-title: Quantification of larval zebrafish motor function in multiwell plates using open-source MATLAB applications publication-title: Nat. Protoc. contributor: fullname: Burton – volume: 364 start-page: 1167 year: 2004 end-page: 1169 ident: bib11 article-title: Alpha-synuclein locus duplication as a cause of familial Parkinson's disease publication-title: Lancet contributor: fullname: Hulihan – volume: 281 start-page: 36228 year: 2006 end-page: 36235 ident: bib37 article-title: Link between mitochondria and NADPH oxidase 1 isozyme for the sustained production of reactive oxygen species and cell death publication-title: J. Biol. Chem. contributor: fullname: Um – volume: 95 start-page: 238 year: 2016 end-page: 249 ident: bib18 article-title: Live imaging of mitochondrial dynamics in CNS dopaminergic neurons in vivo demonstrates early reversal of mitochondrial transport following MPP(+) exposure publication-title: Neurobiol. Dis. contributor: fullname: Watkins – volume: 287 start-page: 2971 year: 2012 end-page: 2983 ident: bib44 article-title: Hypokinesia and reduced dopamine levels in zebrafish lacking beta- and gamma1-synucleins publication-title: J. Biol. Chem. contributor: fullname: Burton – volume: 302 start-page: 841 year: 2003 ident: bib62 article-title: alpha-Synuclein locus triplication causes Parkinson's disease publication-title: Science contributor: fullname: Nussbaum – volume: 56 start-page: 1184 year: 1991 end-page: 1190 ident: bib53 article-title: Interaction of 1-methyl-4-phenylpyridinium ion (MPP+) and its analogs with the rotenone/piericidin binding site of NADH dehydrogenase publication-title: J. Neurochem. contributor: fullname: Singer – volume: 15 start-page: 855 year: 2011 end-page: 871 ident: bib28 article-title: Single-cell redox imaging demonstrates a distinctive response of dopaminergic neurons to oxidative insults publication-title: Antioxid. Redox Signal. contributor: fullname: Burton – volume: 589 start-page: 3703 year: 2011 end-page: 3708 ident: bib9 article-title: Automated measurement of zebrafish larval movement publication-title: J. Physiol. contributor: fullname: Burton – volume: 8 year: 2010 ident: bib47 article-title: PINK1 is selectively stabilized on impaired mitochondria to activate Parkin publication-title: PLoS Biol. contributor: fullname: Youle – volume: 23 start-page: 10756 year: 2003 end-page: 10764 ident: bib58 article-title: Mechanism of toxicity in rotenone models of Parkinson's disease publication-title: J. Neurosci. contributor: fullname: Greenamyre – volume: 6 start-page: 8 year: 2011 ident: bib3 article-title: Glutathione peroxidase 4 is associated with neuromelanin in substantia nigra and dystrophic axons in putamen of Parkinson's brain publication-title: Mol. Neurodegener. contributor: fullname: Ross – volume: 18 start-page: 1543 year: 2007 end-page: 1546 ident: bib40 article-title: Localization of alpha-synuclein to mitochondria within midbrain of mice publication-title: Neuroreport contributor: fullname: Cai – volume: 34 start-page: 487 year: 2009 end-page: 500 ident: bib66 article-title: Proteomic identification of dopamine-conjugated proteins from isolated rat brain mitochondria and SH-SY5Y cells publication-title: Neurobiol. Dis. contributor: fullname: Hastings – volume: 104 start-page: 18742 year: 2007 end-page: 18747 ident: bib19 article-title: S-nitrosylation of peroxiredoxin 2 promotes oxidative stress-induced neuronal cell death in Parkinson's disease publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Lipton – volume: 524 start-page: 2130 year: 2016 end-page: 2141 ident: bib68 article-title: Expression dynamics of NADPH oxidases during early zebrafish development publication-title: J. Comp. Neurol. contributor: fullname: Suter – volume: 439 start-page: 125 year: 2008 ident: 10.1016/j.redox.2020.101695_bib57 article-title: Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells publication-title: Neurosci. Lett. doi: 10.1016/j.neulet.2008.05.005 contributor: fullname: Shavali – volume: 34 start-page: 279 year: 2009 ident: 10.1016/j.redox.2020.101695_bib8 article-title: A highly reproducible rotenone model of Parkinson's disease publication-title: Neurobiol. Dis. doi: 10.1016/j.nbd.2009.01.016 contributor: fullname: Cannon – volume: 18 start-page: 106 year: 1998 ident: 10.1016/j.redox.2020.101695_bib34 article-title: Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease publication-title: Nat. Genet. doi: 10.1038/ng0298-106 contributor: fullname: Kruger – volume: 34 start-page: 487 year: 2009 ident: 10.1016/j.redox.2020.101695_bib66 article-title: Proteomic identification of dopamine-conjugated proteins from isolated rat brain mitochondria and SH-SY5Y cells publication-title: Neurobiol. Dis. doi: 10.1016/j.nbd.2009.03.004 contributor: fullname: Van Laar – volume: 93 start-page: 1956 year: 1996 ident: 10.1016/j.redox.2020.101695_bib26 article-title: Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.93.5.1956 contributor: fullname: Hastings – volume: 524 start-page: 2130 year: 2016 ident: 10.1016/j.redox.2020.101695_bib68 article-title: Expression dynamics of NADPH oxidases during early zebrafish development publication-title: J. Comp. Neurol. doi: 10.1002/cne.23938 contributor: fullname: Weaver – volume: 452 start-page: 8 year: 2009 ident: 10.1016/j.redox.2020.101695_bib5 article-title: Post-transcriptional regulation of mRNA associated with DJ-1 in sporadic Parkinson disease publication-title: Neurosci. Lett. doi: 10.1016/j.neulet.2008.12.053 contributor: fullname: Blackinton – volume: 5 start-page: 553 year: 2008 ident: 10.1016/j.redox.2020.101695_bib22 article-title: Real-time imaging of the intracellular glutathione redox potential publication-title: Nat. Methods doi: 10.1038/nmeth.1212 contributor: fullname: Gutscher – volume: 183 start-page: 795 year: 2008 ident: 10.1016/j.redox.2020.101695_bib46 article-title: Parkin is recruited selectively to impaired mitochondria and promotes their autophagy publication-title: J. Cell Biol. doi: 10.1083/jcb.200809125 contributor: fullname: Narendra – volume: 209 start-page: 975 year: 2012 ident: 10.1016/j.redox.2020.101695_bib41 article-title: Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice publication-title: J. Exp. Med. doi: 10.1084/jem.20112457 contributor: fullname: Luk – volume: 41 start-page: 469 year: 2009 ident: 10.1016/j.redox.2020.101695_bib25 article-title: The role of dopamine oxidation in mitochondrial dysfunction: implications for Parkinson's disease publication-title: J. Bioenerg. Biomembr. doi: 10.1007/s10863-009-9257-z contributor: fullname: Hastings – volume: 32 start-page: 13488 year: 2012 ident: 10.1016/j.redox.2020.101695_bib35 article-title: The conserved dopaminergic diencephalospinal tract mediates vertebrate locomotor development in zebrafish larvae publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.1638-12.2012 contributor: fullname: Lambert – volume: 889 start-page: 316 year: 2001 ident: 10.1016/j.redox.2020.101695_bib54 article-title: The teleostean (zebrafish) dopaminergic system ascending to the subpallium (striatum) is located in the basal diencephalon (posterior tuberculum) publication-title: Brain Res. doi: 10.1016/S0006-8993(00)03174-7 contributor: fullname: Rink – volume: 283 start-page: 9986 year: 2008 ident: 10.1016/j.redox.2020.101695_bib38 article-title: Oxidative modification of peroxiredoxin is associated with drug-induced apoptotic signaling in experimental models of Parkinson disease publication-title: J. Biol. Chem. doi: 10.1074/jbc.M800426200 contributor: fullname: Lee – volume: 281 start-page: 36228 year: 2006 ident: 10.1016/j.redox.2020.101695_bib37 article-title: Link between mitochondria and NADPH oxidase 1 isozyme for the sustained production of reactive oxygen species and cell death publication-title: J. Biol. Chem. doi: 10.1074/jbc.M606702200 contributor: fullname: Lee – volume: 23 start-page: 10756 year: 2003 ident: 10.1016/j.redox.2020.101695_bib58 article-title: Mechanism of toxicity in rotenone models of Parkinson's disease publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.23-34-10756.2003 contributor: fullname: Sherer – volume: 15 start-page: 855 year: 2011 ident: 10.1016/j.redox.2020.101695_bib28 article-title: Single-cell redox imaging demonstrates a distinctive response of dopaminergic neurons to oxidative insults publication-title: Antioxid. Redox Signal. doi: 10.1089/ars.2010.3629 contributor: fullname: Horowitz – volume: 9 start-page: 1533 year: 2014 ident: 10.1016/j.redox.2020.101695_bib77 article-title: Quantification of larval zebrafish motor function in multiwell plates using open-source MATLAB applications publication-title: Nat. Protoc. doi: 10.1038/nprot.2014.094 contributor: fullname: Zhou – volume: 352 start-page: 393 year: 2011 ident: 10.1016/j.redox.2020.101695_bib21 article-title: Identification of a dopaminergic enhancer indicates complexity in vertebrate dopamine neuron phenotype specification publication-title: Dev. Biol. doi: 10.1016/j.ydbio.2011.01.023 contributor: fullname: Fujimoto – volume: 36 start-page: 2304 year: 2015 ident: 10.1016/j.redox.2020.101695_bib31 article-title: P2X7 receptor is critical in alpha-synuclein--mediated microglial NADPH oxidase activation publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2015.03.015 contributor: fullname: Jiang – volume: 289 start-page: 21490 year: 2014 ident: 10.1016/j.redox.2020.101695_bib42 article-title: Soluble, prefibrillar alpha-synuclein oligomers promote complex I-dependent, Ca2+-induced mitochondrial dysfunction publication-title: J. Biol. Chem. doi: 10.1074/jbc.M113.545749 contributor: fullname: Luth – volume: 8 year: 2010 ident: 10.1016/j.redox.2020.101695_bib47 article-title: PINK1 is selectively stabilized on impaired mitochondria to activate Parkin publication-title: PLoS Biol. doi: 10.1371/journal.pbio.1000298 contributor: fullname: Narendra – volume: 104 start-page: 18742 year: 2007 ident: 10.1016/j.redox.2020.101695_bib19 article-title: S-nitrosylation of peroxiredoxin 2 promotes oxidative stress-induced neuronal cell death in Parkinson's disease publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0705904104 contributor: fullname: Fang – volume: 287 start-page: 2971 year: 2012 ident: 10.1016/j.redox.2020.101695_bib44 article-title: Hypokinesia and reduced dopamine levels in zebrafish lacking beta- and gamma1-synucleins publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.308312 contributor: fullname: Milanese – volume: 357 start-page: 891 year: 2017 ident: 10.1016/j.redox.2020.101695_bib45 article-title: beta2-Adrenoreceptor is a regulator of the alpha-synuclein gene driving risk of Parkinson's disease publication-title: Science doi: 10.1126/science.aaf3934 contributor: fullname: Mittal – volume: 36 start-page: 348 year: 1994 ident: 10.1016/j.redox.2020.101695_bib60 article-title: Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia publication-title: Ann. Neurol. doi: 10.1002/ana.410360305 contributor: fullname: Sian – volume: 24 start-page: 197 year: 2003 ident: 10.1016/j.redox.2020.101695_bib6 article-title: Staging of brain pathology related to sporadic Parkinson's disease publication-title: Neurobiol. Aging doi: 10.1016/S0197-4580(02)00065-9 contributor: fullname: Braak – volume: 13 start-page: 621 year: 2010 ident: 10.1016/j.redox.2020.101695_bib43 article-title: Fluorescent protein-based redox probes publication-title: Antioxidants Redox Signal. doi: 10.1089/ars.2009.2948 contributor: fullname: Meyer – volume: 152 start-page: 879 year: 1998 ident: 10.1016/j.redox.2020.101695_bib1 article-title: Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies publication-title: Am. J. Pathol. contributor: fullname: Baba – volume: 302 start-page: 841 year: 2003 ident: 10.1016/j.redox.2020.101695_bib62 article-title: alpha-Synuclein locus triplication causes Parkinson's disease publication-title: Science doi: 10.1126/science.1090278 contributor: fullname: Singleton – volume: 65 start-page: 419 year: 2013 ident: 10.1016/j.redox.2020.101695_bib27 article-title: Dopamine quinone modifies and decreases the abundance of the mitochondrial selenoprotein glutathione peroxidase 4 publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2013.06.030 contributor: fullname: Hauser – volume: 100 start-page: 14 year: 2016 ident: 10.1016/j.redox.2020.101695_bib7 article-title: Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2016.04.001 contributor: fullname: Brand – volume: 276 start-page: 29251 year: 2001 ident: 10.1016/j.redox.2020.101695_bib39 article-title: H(2)O(2)-induced O(2) production by a non-phagocytic NAD(P)H oxidase causes oxidant injury publication-title: J. Biol. Chem. doi: 10.1074/jbc.M102124200 contributor: fullname: Li – volume: 237 start-page: 2490 year: 2008 ident: 10.1016/j.redox.2020.101695_bib64 article-title: Discovery and characterization of three novel synuclein genes in zebrafish publication-title: Dev. Dynam. doi: 10.1002/dvdy.21569 contributor: fullname: Sun – volume: 289 start-page: 8312 year: 2014 ident: 10.1016/j.redox.2020.101695_bib52 article-title: The 2-oxoacid dehydrogenase complexes in mitochondria can produce superoxide/hydrogen peroxide at much higher rates than complex I publication-title: J. Biol. Chem. doi: 10.1074/jbc.M113.545301 contributor: fullname: Quinlan – volume: 44 start-page: 9 year: 2011 ident: 10.1016/j.redox.2020.101695_bib20 article-title: Evaluation of spontaneous propulsive movement as a screening tool to detect rescue of Parkinsonism phenotypes in zebrafish models publication-title: Neurobiol. Dis. doi: 10.1016/j.nbd.2011.05.016 contributor: fullname: Farrell – volume: 125 start-page: 2721 year: 2015 ident: 10.1016/j.redox.2020.101695_bib76 article-title: shRNA targeting alpha-synuclein prevents neurodegeneration in a Parkinson's disease model publication-title: J. Clin. Invest. doi: 10.1172/JCI64502 contributor: fullname: Zharikov – volume: 6 start-page: 8 year: 2011 ident: 10.1016/j.redox.2020.101695_bib3 article-title: Glutathione peroxidase 4 is associated with neuromelanin in substantia nigra and dystrophic axons in putamen of Parkinson's brain publication-title: Mol. Neurodegener. doi: 10.1186/1750-1326-6-8 contributor: fullname: Bellinger – volume: 13 start-page: 158 year: 2016 ident: 10.1016/j.redox.2020.101695_bib67 article-title: Identification of a specific alpha-synuclein peptide (alpha-Syn 29-40) capable of eliciting microglial superoxide production to damage dopaminergic neurons publication-title: J. Neuroinflammation doi: 10.1186/s12974-016-0606-7 contributor: fullname: Wang – volume: 33 start-page: 305 year: 1982 ident: 10.1016/j.redox.2020.101695_bib49 article-title: Parkinson's disease: a disorder due to nigral glutathione deficiency? publication-title: Neurosci. Lett. doi: 10.1016/0304-3940(82)90390-1 contributor: fullname: Perry – volume: 3 start-page: 9 year: 2015 ident: 10.1016/j.redox.2020.101695_bib74 article-title: Loss of angiotensin II receptor expression in dopamine neurons in Parkinson's disease correlates with pathological progression and is accompanied by increases in Nox4- and 8-OH guanosine-related nucleic acid oxidation and caspase-3 activation publication-title: Acta Neuropathologica Commun. doi: 10.1186/s40478-015-0189-z contributor: fullname: Zawada – volume: 58 start-page: 343 year: 1985 ident: 10.1016/j.redox.2020.101695_bib32 article-title: Glutathione peroxidase activity in Parkinson's disease brain publication-title: Neurosci. Lett. doi: 10.1016/0304-3940(85)90078-3 contributor: fullname: Kish – volume: 119 start-page: 866 year: 2011 ident: 10.1016/j.redox.2020.101695_bib65 article-title: Rotenone, paraquat, and Parkinson's disease publication-title: Environ. Health Perspect. doi: 10.1289/ehp.1002839 contributor: fullname: Tanner – volume: 125 start-page: 146 year: 2019 ident: 10.1016/j.redox.2020.101695_bib75 article-title: Long-term RNAi knockdown of alpha-synuclein in the adult rat substantia nigra without neurodegeneration publication-title: Neurobiol. Dis. doi: 10.1016/j.nbd.2019.01.004 contributor: fullname: Zharikov – volume: 8 start-page: 342ra378 year: 2016 ident: 10.1016/j.redox.2020.101695_bib17 article-title: alpha-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.aaf3634 contributor: fullname: Di Maio – volume: 388 start-page: 839 year: 1997 ident: 10.1016/j.redox.2020.101695_bib63 article-title: Alpha-synuclein in Lewy bodies publication-title: Nature doi: 10.1038/42166 contributor: fullname: Spillantini – volume: 364 start-page: 1167 year: 2004 ident: 10.1016/j.redox.2020.101695_bib11 article-title: Alpha-synuclein locus duplication as a cause of familial Parkinson's disease publication-title: Lancet doi: 10.1016/S0140-6736(04)17103-1 contributor: fullname: Chartier-Harlin – volume: 41 start-page: 1308 year: 2009 ident: 10.1016/j.redox.2020.101695_bib61 article-title: Genome-wide association study reveals genetic risk underlying Parkinson's disease publication-title: Nat. Genet. doi: 10.1038/ng.487 contributor: fullname: Simon-Sanchez – volume: 314 start-page: 2076 year: 2008 ident: 10.1016/j.redox.2020.101695_bib13 article-title: Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification publication-title: Exp. Cell Res. doi: 10.1016/j.yexcr.2008.03.012 contributor: fullname: Cole – volume: 284 start-page: 31532 year: 2009 ident: 10.1016/j.redox.2020.101695_bib23 article-title: Proximity-based protein thiol oxidation by H2O2-scavenging peroxidases publication-title: J. Biol. Chem. doi: 10.1074/jbc.M109.059246 contributor: fullname: Gutscher – start-page: 377 year: 2020 ident: 10.1016/j.redox.2020.101695_bib2 article-title: Parkinson's disease contributor: fullname: Bartel – volume: 95 start-page: 238 year: 2016 ident: 10.1016/j.redox.2020.101695_bib18 article-title: Live imaging of mitochondrial dynamics in CNS dopaminergic neurons in vivo demonstrates early reversal of mitochondrial transport following MPP(+) exposure publication-title: Neurobiol. Dis. doi: 10.1016/j.nbd.2016.07.020 contributor: fullname: Dukes – volume: 33 start-page: 678 year: 2018 ident: 10.1016/j.redox.2020.101695_bib33 article-title: Disease modification for Parkinson's disease: axonal regeneration and trophic factors publication-title: Mov. Disord. doi: 10.1002/mds.27383 contributor: fullname: Kordower – volume: 1 start-page: 1269 year: 1989 ident: 10.1016/j.redox.2020.101695_bib56 article-title: Mitochondrial complex I deficiency in Parkinson's disease publication-title: Lancet doi: 10.1016/S0140-6736(89)92366-0 contributor: fullname: Schapira – volume: 9 year: 2020 ident: 10.1016/j.redox.2020.101695_bib73 article-title: Chemoptogenetic ablation of neuronal mitochondria in vivo with spatiotemporal precision and controllable severity publication-title: eLife doi: 10.7554/eLife.51845 contributor: fullname: Xie – volume: 16 start-page: 1033 year: 2012 ident: 10.1016/j.redox.2020.101695_bib12 article-title: NADPH oxidase 1-mediated oxidative stress leads to dopamine neuron death in Parkinson's disease publication-title: Antioxidants Redox Signal. doi: 10.1089/ars.2011.3960 contributor: fullname: Choi – volume: 56 start-page: 1184 year: 1991 ident: 10.1016/j.redox.2020.101695_bib53 article-title: Interaction of 1-methyl-4-phenylpyridinium ion (MPP+) and its analogs with the rotenone/piericidin binding site of NADH dehydrogenase publication-title: J. Neurochem. doi: 10.1111/j.1471-4159.1991.tb11409.x contributor: fullname: Ramsay – volume: 2 start-page: 183 year: 2008 ident: 10.1016/j.redox.2020.101695_bib69 article-title: Transparent adult zebrafish as a tool for in vivo transplantation analysis publication-title: Cell Stem Cell doi: 10.1016/j.stem.2007.11.002 contributor: fullname: White – volume: 37 start-page: 714 year: 1995 ident: 10.1016/j.redox.2020.101695_bib24 article-title: Low platelet mitochondrial complex I and complex II/III activity in early untreated Parkinson's disease publication-title: Ann. Neurol. doi: 10.1002/ana.410370604 contributor: fullname: Haas – volume: 14 start-page: 600 year: 2018 ident: 10.1016/j.redox.2020.101695_bib29 article-title: Integrin CD11b mediates alpha-synuclein-induced activation of NADPH oxidase through a Rho-dependent pathway publication-title: Redox Biol doi: 10.1016/j.redox.2017.11.010 contributor: fullname: Hou – volume: 45 start-page: 625 year: 2007 ident: 10.1016/j.redox.2020.101695_bib51 article-title: Viral 2A peptides allow expression of multiple proteins from a single ORF in transgenic zebrafish embryos publication-title: Genesis doi: 10.1002/dvg.20338 contributor: fullname: Provost – volume: 82 start-page: 2173 year: 1985 ident: 10.1016/j.redox.2020.101695_bib30 article-title: Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.82.7.2173 contributor: fullname: Javitch – volume: 4 start-page: 1367 year: 2005 ident: 10.1016/j.redox.2020.101695_bib15 article-title: Cross talk between mitochondria and superoxide generating NADPH oxidase in breast and ovarian tumors publication-title: Canc. Biol. Ther. doi: 10.4161/cbt.4.12.2233 contributor: fullname: Desouki – volume: 100 start-page: 6145 year: 2003 ident: 10.1016/j.redox.2020.101695_bib72 article-title: NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0937239100 contributor: fullname: Wu – volume: 283 start-page: 9089 year: 2008 ident: 10.1016/j.redox.2020.101695_bib16 article-title: Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain publication-title: J. Biol. Chem. doi: 10.1074/jbc.M710012200 contributor: fullname: Devi – volume: 219 start-page: 979 year: 1983 ident: 10.1016/j.redox.2020.101695_bib36 article-title: Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis publication-title: Science doi: 10.1126/science.6823561 contributor: fullname: Langston – volume: 3 start-page: 1301 year: 2000 ident: 10.1016/j.redox.2020.101695_bib4 article-title: Chronic systemic pesticide exposure reproduces features of Parkinson's disease publication-title: Nat. Neurosci. doi: 10.1038/81834 contributor: fullname: Betarbet – volume: 41 start-page: 1303 year: 2009 ident: 10.1016/j.redox.2020.101695_bib55 article-title: Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease publication-title: Nat. Genet. doi: 10.1038/ng.485 contributor: fullname: Satake – volume: 126 start-page: 119 year: 2010 ident: 10.1016/j.redox.2020.101695_bib70 article-title: Effects of tempol and redox-cycling nitroxides in models of oxidative stress publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2010.01.003 contributor: fullname: Wilcox – volume: 211 start-page: 511 year: 2008 ident: 10.1016/j.redox.2020.101695_bib71 article-title: Enhanced function in the good forelimb of hemi-Parkinson rats: compensatory adaptation for contralateral postural instability? publication-title: Exp. Neurol. doi: 10.1016/j.expneurol.2008.02.024 contributor: fullname: Woodlee – volume: 18 start-page: 1543 year: 2007 ident: 10.1016/j.redox.2020.101695_bib40 article-title: Localization of alpha-synuclein to mitochondria within midbrain of mice publication-title: Neuroreport doi: 10.1097/WNR.0b013e3282f03db4 contributor: fullname: Li – volume: 276 start-page: 2045 year: 1997 ident: 10.1016/j.redox.2020.101695_bib50 article-title: Mutation in the alpha-synuclein gene identified in families with Parkinson's disease publication-title: Science doi: 10.1126/science.276.5321.2045 contributor: fullname: Polymeropoulos – volume: 275 start-page: 25130 year: 2000 ident: 10.1016/j.redox.2020.101695_bib10 article-title: Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1 alpha during hypoxia: a mechanism of O2 sensing publication-title: J. Biol. Chem. doi: 10.1074/jbc.M001914200 contributor: fullname: Chandel – volume: 32 start-page: 14465 year: 2012 ident: 10.1016/j.redox.2020.101695_bib14 article-title: NADPH oxidase 1 mediates alpha-synucleinopathy in Parkinson's disease publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.2246-12.2012 contributor: fullname: Cristovao – volume: 104 start-page: 661 year: 1997 ident: 10.1016/j.redox.2020.101695_bib48 article-title: Alterations in the distribution of glutathione in the substantia nigra in Parkinson's disease publication-title: J. Neural. Transm. doi: 10.1007/BF01291884 contributor: fullname: Pearce – volume: 179 start-page: 9 year: 2003 ident: 10.1016/j.redox.2020.101695_bib59 article-title: Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation publication-title: Exp. Neurol. doi: 10.1006/exnr.2002.8072 contributor: fullname: Sherer – volume: 589 start-page: 3703 year: 2011 ident: 10.1016/j.redox.2020.101695_bib9 article-title: Automated measurement of zebrafish larval movement publication-title: J. Physiol. doi: 10.1113/jphysiol.2011.207308 contributor: fullname: Cario |
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Snippet | Convergent evidence implicates impaired mitochondrial function and α-Synuclein accumulation as critical upstream events in the pathogenesis of Parkinson's... |
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StartPage | 101695 |
SubjectTerms | Dopaminergic neuron Glutathione Parkinson's disease Peroxide Research Paper Zebrafish α-Synuclein |
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Title | α-Synuclein amplifies cytoplasmic peroxide flux and oxidative stress provoked by mitochondrial inhibitors in CNS dopaminergic neurons in vivo |
URI | https://dx.doi.org/10.1016/j.redox.2020.101695 https://www.ncbi.nlm.nih.gov/pubmed/32905883 https://search.proquest.com/docview/2441603384 https://pubmed.ncbi.nlm.nih.gov/PMC7486459 https://doaj.org/article/ddf8ea687ea749669a9ee7430fe75b27 |
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