Effect of hepatic stimulator substance administration on tissue regeneration due to thioacetamide-induced liver injury in rats

• Published in: Scandinavian journal of gastroenterology Vol. 33; no. 6; p. 656
• Main Authors: Theocharis, S E, Margeli, A P, Agapitos, E V, Mykoniatis, M G, Kittas, C N, Davaris, P S
• Format: Journal Article
• Language: English
• Published: England 1998
• Subjects: Alanine Transaminase - blood; Animals; Aspartate Aminotransferases - blood; Carcinogens; Chemical and Drug Induced Liver Injury - etiology; Chemical and Drug Induced Liver Injury - physiopathology; Growth Substances - pharmacology; Liver Regeneration - drug effects; Liver Regeneration - physiology; Male; Mitogens - pharmacology; Peptides - pharmacology; Rats; Rats, Wistar; Thioacetamide; Time Factors

Hepatic stimulator substance (HSS) is a known hepatic growth factor that appears to be organ-specific but species-nonspecific. In the present study we investigated the effect of HSS administration in a rat model of liver injury and regeneration induced by thioacetamide (TAA) injection. TAA (300 mg/k...