A novel cell-based assay for dynamically detecting neutrophil extracellular traps-induced lung epithelial injuries

• Published in: Experimental cell research Vol. 394; no. 2; p. 112101
• Main Authors: Lv, Dandan, Xu, Yiming, Cheng, Hongqiang, Ke, Yuehai, Zhang, Xue, Ying, Kejing
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.09.2020; The Authors. Published by Elsevier Inc
• Subjects: Acute lung injury; Acute Lung Injury - blood; Acute Lung Injury - chemically induced; Acute Lung Injury - diagnostic imaging; Acute Lung Injury - virology; Animals; Betacoronavirus - pathogenicity; Coronavirus Infections - blood; Coronavirus Infections - diagnostic imaging; Coronavirus Infections - virology; COVID-19; Epithelial Cells - pathology; Epithelial Cells - virology; Extracellular Traps - diagnostic imaging; Extracellular Traps - virology; Humans; Lipopolysaccharides - toxicity; Lung - diagnostic imaging; Lung - virology; Lung epithelial cells; Male; Neutrophil extracellular traps; Neutrophils - metabolism; Neutrophils - virology; Pandemics; Pneumonia - blood; Pneumonia - diagnostic imaging; Pneumonia - virology; Pneumonia, Viral - blood; Pneumonia, Viral - diagnostic imaging; Pneumonia, Viral - virology; Respiratory Distress Syndrome - blood; Respiratory Distress Syndrome - pathology; Respiratory Distress Syndrome - virology; SARS-CoV-2; Severe pneumonia; xCELLigence; APAP; Acute lung injury; Lung epithelial cells; PXM; Severe pneumonia; KP; INM; ASA; Neutrophil extracellular traps; NSAIDs; DXM; xCELLigence; KTC

Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS) are common lung disorders characterized by alveolar-capillary barrier disruption and dyspnea, which can cause substantial morbidity and mortality. Currently, a cluster of acute respiratory illnesses, known a...