Molecular Insights into HPV-Driven Cervical Cancer: Oncoproteins, Immune Evasion, and Epigenetic Modifications

Cervical cancer ranks third in mortality and fourth in incidence among women worldwide as one of the leading causes of death from cancer in females. The main reason behind cervical carcinogenesis is long-term infection with high-risk human papillomavirus (HPV) genotypes, particularly HPV16 and HPV18...

Full description

Saved in:
Bibliographic Details
Published inMicroorganisms (Basel) Vol. 13; no. 5; p. 1000
Main Authors Pavelescu, Luciana Alexandra, Mititelu-Zafiu, Nicoleta Larisa, Mindru, Dana Elena, Vladareanu, Radu, Curici, Antoanela
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 27.04.2025
MDPI
Subjects
Cancer
Carcinogenesis
Carcinogens
Cell cycle
Cellular biology
Cervical cancer
DNA methylation
early proteins
Enzymes
Epidemiology
Epigenetic inheritance
Epigenetics
exosomes
Gene expression
Genetic aspects
Genotypes
HPV
Human papillomavirus
Immunization
Immunotherapy
Infection
Infections
miRNA
Molecular modelling
Mortality
Papillomavirus infections
Pathogenesis
Phylogenetics
Public health
Review
Romania
Socioeconomic factors
Therapeutic applications
Tumor suppressor genes
Vaccination
Vaccines
Womens health
Romania
Africa
DNA methylation
miRNA
early proteins
cervical cancer
exosomes
HPV
Online AccessGet full text
ISSN2076-2607
2076-2607
DOI10.3390/microorganisms13051000

Cover

Abstract Cervical cancer ranks third in mortality and fourth in incidence among women worldwide as one of the leading causes of death from cancer in females. The main reason behind cervical carcinogenesis is long-term infection with high-risk human papillomavirus (HPV) genotypes, particularly HPV16 and HPV18. This review investigates HPV distribution across the world, along with cervical cancer molecular development mechanisms and current treatment strategies. Epidemiological data show that disease patterns vary significantly between different geographic regions because underdeveloped nations bear a higher disease burden. The molecular mechanisms of oncogenes E6 and E7 disrupt tumor suppressor pathways, while epigenetic modifications through DNA methylation and miRNA dysregulation promote malignant cell transformation. The reduction in HPV infection through prophylactic vaccination has shown promise, yet barriers related to accessibility and coverage still exist. The therapeutic technologies of gene expression inhibitors together with immunotherapies and epigenetic targeting agents show promise but require optimization to achieve specific targeting while minimizing off-target effects. A combined approach that integrates HPV vaccination with early diagnosis and molecular-specific therapies represents the most effective method to manage cervical cancer impact. The future care of patients will require increased translational research along with better immunization programs to drive prevention and therapeutic outcomes.
AbstractList Cervical cancer ranks third in mortality and fourth in incidence among women worldwide as one of the leading causes of death from cancer in females. The main reason behind cervical carcinogenesis is long-term infection with high-risk human papillomavirus (HPV) genotypes, particularly HPV16 and HPV18. This review investigates HPV distribution across the world, along with cervical cancer molecular development mechanisms and current treatment strategies. Epidemiological data show that disease patterns vary significantly between different geographic regions because underdeveloped nations bear a higher disease burden. The molecular mechanisms of oncogenes E6 and E7 disrupt tumor suppressor pathways, while epigenetic modifications through DNA methylation and miRNA dysregulation promote malignant cell transformation. The reduction in HPV infection through prophylactic vaccination has shown promise, yet barriers related to accessibility and coverage still exist. The therapeutic technologies of gene expression inhibitors together with immunotherapies and epigenetic targeting agents show promise but require optimization to achieve specific targeting while minimizing off-target effects. A combined approach that integrates HPV vaccination with early diagnosis and molecular-specific therapies represents the most effective method to manage cervical cancer impact. The future care of patients will require increased translational research along with better immunization programs to drive prevention and therapeutic outcomes.
Cervical cancer ranks third in mortality and fourth in incidence among women worldwide as one of the leading causes of death from cancer in females. The main reason behind cervical carcinogenesis is long-term infection with high-risk human papillomavirus (HPV) genotypes, particularly HPV16 and HPV18. This review investigates HPV distribution across the world, along with cervical cancer molecular development mechanisms and current treatment strategies. Epidemiological data show that disease patterns vary significantly between different geographic regions because underdeveloped nations bear a higher disease burden. The molecular mechanisms of oncogenes E6 and E7 disrupt tumor suppressor pathways, while epigenetic modifications through DNA methylation and miRNA dysregulation promote malignant cell transformation. The reduction in HPV infection through prophylactic vaccination has shown promise, yet barriers related to accessibility and coverage still exist. The therapeutic technologies of gene expression inhibitors together with immunotherapies and epigenetic targeting agents show promise but require optimization to achieve specific targeting while minimizing off-target effects. A combined approach that integrates HPV vaccination with early diagnosis and molecular-specific therapies represents the most effective method to manage cervical cancer impact. The future care of patients will require increased translational research along with better immunization programs to drive prevention and therapeutic outcomes.Cervical cancer ranks third in mortality and fourth in incidence among women worldwide as one of the leading causes of death from cancer in females. The main reason behind cervical carcinogenesis is long-term infection with high-risk human papillomavirus (HPV) genotypes, particularly HPV16 and HPV18. This review investigates HPV distribution across the world, along with cervical cancer molecular development mechanisms and current treatment strategies. Epidemiological data show that disease patterns vary significantly between different geographic regions because underdeveloped nations bear a higher disease burden. The molecular mechanisms of oncogenes E6 and E7 disrupt tumor suppressor pathways, while epigenetic modifications through DNA methylation and miRNA dysregulation promote malignant cell transformation. The reduction in HPV infection through prophylactic vaccination has shown promise, yet barriers related to accessibility and coverage still exist. The therapeutic technologies of gene expression inhibitors together with immunotherapies and epigenetic targeting agents show promise but require optimization to achieve specific targeting while minimizing off-target effects. A combined approach that integrates HPV vaccination with early diagnosis and molecular-specific therapies represents the most effective method to manage cervical cancer impact. The future care of patients will require increased translational research along with better immunization programs to drive prevention and therapeutic outcomes.
Audience Academic
Author Mititelu-Zafiu, Nicoleta Larisa
Vladareanu, Radu
Curici, Antoanela
Mindru, Dana Elena
Pavelescu, Luciana Alexandra
AuthorAffiliation 1 Department of Cellular and Molecular Biology and Histology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania; luciana.pavelescu@umfcd.ro
4 Department of Obstetrics-Gynecology and Neonatology, Elias Emergency Hospital Bucharest, 011461 Bucharest, Romania
5 Obstetrics and Gynecology, University of Medicine and Pharmacy Carol Davila, 050474 Bucharest, Romania
3 Department of Pediatrics, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania; mindru.dana@umfiasi.ro
2 Synevo Romania, 021408 Bucharest, Romania; nicoleta.mititelu@synevo.ro
AuthorAffiliation_xml – name: 1 Department of Cellular and Molecular Biology and Histology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania; luciana.pavelescu@umfcd.ro
– name: 2 Synevo Romania, 021408 Bucharest, Romania; nicoleta.mititelu@synevo.ro
– name: 3 Department of Pediatrics, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania; mindru.dana@umfiasi.ro
– name: 5 Obstetrics and Gynecology, University of Medicine and Pharmacy Carol Davila, 050474 Bucharest, Romania
– name: 4 Department of Obstetrics-Gynecology and Neonatology, Elias Emergency Hospital Bucharest, 011461 Bucharest, Romania
Author_xml – sequence: 1
  givenname: Luciana Alexandra
  orcidid: 0000-0002-7027-6956
  surname: Pavelescu
  fullname: Pavelescu, Luciana Alexandra
– sequence: 2
  givenname: Nicoleta Larisa
  surname: Mititelu-Zafiu
  fullname: Mititelu-Zafiu, Nicoleta Larisa
– sequence: 3
  givenname: Dana Elena
  surname: Mindru
  fullname: Mindru, Dana Elena
– sequence: 4
  givenname: Radu
  surname: Vladareanu
  fullname: Vladareanu, Radu
– sequence: 5
  givenname: Antoanela
  surname: Curici
  fullname: Curici, Antoanela
BackLink https://www.ncbi.nlm.nih.gov/pubmed/40431173$$D View this record in MEDLINE/PubMed
BookMark eNptkk1vEzEQhleoiH7Qv1BZ4sKhKf5ar5cLqkJKI7UqB-BqOfY4dbRrB3s3Uv89TlNKgyofbM0883pm9B5XByEGqKozgi8Ya_Gn3psUY1rq4HOfCcM1wRi_qY4obsSECtwcvHgfVqc5rwqAW8JkTd5VhxxzRkjDjqpwGzswY6cTmofsl_dDRj4MEV1__zX5mvwGAppC2nijOzTVwUD6jO6CiesUB_Ahn6N5348B0Gyjs4_hHOlg0WztlxBg8AbdRutdKR9KMr-v3jrdZTh9uk-qn1ezH9Pryc3dt_n08mZialoPE1I7yWppNWOULQxvLTfYYmd1Q1wLthYl2nIB0lGLpStjUQzCUGYaIQhjJ9V8p2ujXql18r1ODypqrx4DZXdKp9JdB6pljhdtay2jvOEgGRHWmsYuCHGE2aL1Zae1Hhc9WANhSLrbE93PBH-vlnGjCCWENXzbzccnhRR_j5AH1ftsoOt0gDhmxSihjaSU8oJ--A9dxTGFsqtHCkvaYPmPWuoygQ8ulo_NVlRdSk4bgSUWhbp4hSrHQnFQsZTzJb5XcPZy0ucR_9qlAGIHFP_lnMA9IwSrrTXV69ZkfwC1Fdk5
Cites_doi 10.1016/j.ajog.2012.09.007
10.1016/j.cell.2018.01.004
10.3892/mmr.2017.7231
10.1093/jnci/dji186
10.1016/j.yexcr.2005.01.015
10.1186/s13046-021-01841-w
10.1128/jvi.15.5.1239-1247.1975
10.1111/exd.13228
10.3390/v7031079
10.1038/nature21386
10.1007/s11033-020-05435-1
10.1007/s10585-023-10256-0
10.32604/or.2022.026776
10.1089/jwh.2018.7380
10.1186/1476-4598-2-24
10.3390/cancers14010193
10.7150/jca.21444
10.1093/carcin/bgp066
10.1186/s40425-016-0184-3
10.1038/sj.bjc.6600688
10.18632/oncotarget.5283
10.1111/aji.12030
10.1128/JVI.79.12.7889-7898.2005
10.1038/ncb1722
10.2152/jmi.51.146
10.1016/j.vaccine.2006.05.026
10.3389/fmicb.2019.03116
10.1074/jbc.M303608200
10.1159/000494985
10.1016/j.tvr.2021.200221
10.3390/cells10030668
10.1099/0022-1317-76-9-2407
10.1097/AOG.0000000000004000
10.1056/NEJMoa021641
10.1016/j.cegh.2020.09.012
10.1002/ijc.33566
10.1136/ijgc-00009577-200801000-00011
10.2196/jmir.4343
10.1016/j.ygyno.2004.10.019
10.1016/j.molmed.2024.05.009
10.1002/ijc.32688
10.7150/ijms.20809
10.1371/journal.pone.0011780
10.1038/s41598-025-92861-5
10.1158/2159-8290.CD-22-0900
10.1186/1476-4598-9-167
10.1186/s12889-016-3969-x
10.3727/096504015X14496932933610
10.3390/cells10113104
10.1016/j.antiviral.2020.104794
10.1006/viro.1996.0530
10.1186/1743-422X-10-175
10.21147/j.issn.1000-9604.2020.06.05
10.2147/IDR.S296709
10.7150/ijbs.67770
10.1093/nar/gkx1103
10.3390/ijms252312714
10.1016/j.cca.2018.11.009
10.1038/sj.jid.5700559
10.3322/caac.21660
10.1016/j.virusres.2017.01.022
10.1128/jvi.67.11.6424-6431.1993
10.1074/jbc.M101932200
10.1586/era.12.159
10.3892/br.2021.1436
10.1016/j.jmoldx.2021.01.016
10.1016/j.ypmed.2021.106596
10.3322/caac.21139
10.1016/j.arcmed.2014.10.008
10.4103/0971-5851.96961
10.1177/1933719111432874
10.1615/CritRevImmunol.2016017387
10.1016/j.bbagrm.2011.05.005
10.1007/s00432-016-2189-1
10.1186/s12985-016-0515-5
10.1158/1055-9965.EPI-04-0812
10.3892/ol.2020.11697
10.1002/ijc.30716
10.1038/srep05750
10.1038/nm1517
10.1186/s13643-019-0983-y
10.1128/JVI.00502-16
10.1128/jvi.01503-21
10.1038/s41417-023-00682-3
10.1111/1523-1747.ep12371705
10.4161/epi.23605
10.1038/ni.2647
10.1016/j.vaccine.2012.07.055
10.3389/fonc.2021.629350
10.1038/30400
10.1371/journal.pone.0021646
10.1038/nrc2886
10.1002/jmv.20153
10.2174/1874357901105010080
10.1002/ijc.32614
10.1016/j.bbrc.2013.04.060
10.1038/onc.2010.613
10.1101/144576
10.3390/ijms252312991
10.1371/journal.pone.0072565
10.1016/0092-8674(91)90529-8
10.1186/1471-2407-14-957
10.1016/j.vaccine.2013.07.013
10.1038/sj.bjc.6604978
10.3390/molecules19056263
10.1016/j.currproblcancer.2018.03.003
10.1002/pmic.201800149
10.1038/nature16481
10.1038/nrdp.2016.86
10.1046/j.1365-2958.2000.02001.x
10.1128/JVI.01879-14
10.1111/j.1471-4159.2007.04633.x
10.18689/mjv-1000113
10.1016/S1470-2045(21)00453-8
10.1128/CMR.16.1.1-17.2003
10.1016/S2214-109X(19)30067-1
10.1016/j.virol.2013.07.008
10.1006/scbi.1996.0042
10.1038/s41598-023-42022-3
10.1016/S1470-2045(05)70086-3
10.7314/APJCP.2014.15.9.3851
10.1038/s41598-019-49886-4
10.1016/j.ygyno.2013.08.025
10.1016/j.virol.2013.07.020
10.1158/0008-5472.CAN-06-0499
10.1186/s12929-019-0520-2
10.1016/j.critrevonc.2021.103343
10.1128/JVI.79.10.6565-6569.2005
10.1111/cas.13476
10.1016/j.bpobgyn.2017.08.006
10.1016/j.ygyno.2010.01.024
10.1016/j.critrevonc.2022.103675
10.3389/fcell.2024.1397945
10.1128/JVI.00537-17
10.1016/j.immuni.2006.01.005
10.1126/scisignal.aag1064
10.1002/ijc.20558
10.18632/oncotarget.22036
10.1016/S2214-109X(19)30488-7
10.1007/s13277-016-5071-5
10.1038/nrg1427
10.3390/v10020080
10.3390/v9080211
10.1128/JVI.00078-10
10.1038/s41418-023-01242-w
10.3390/ijerph19053114
10.3892/or.2014.3142
10.1016/j.virol.2017.05.005
10.1371/journal.pone.0234873
10.1016/j.scr.2013.09.011
10.1128/JCM.00517-06
10.1016/S0006-3495(91)82181-6
10.1002/ijc.27906
10.1111/cas.15664
10.1016/j.canlet.2009.09.022
10.3390/v12090977
10.1016/j.virol.2004.03.033
10.1042/BSR20171268
10.7150/ijbs.21547
10.1002/jmv.27900
10.1089/107999004323034114
10.1016/j.cancergen.2020.09.003
10.1128/JVI.78.24.13954-13965.2004
10.1093/jnci/89.3.245
10.1007/s10495-010-0534-4
10.3390/v9090254
10.1007/s13402-011-0069-x
10.1309/VQXFT880JXC7QD2W
10.1002/cbin.10301
10.1128/JVI.02063-08
10.3390/ijerph121113981
10.1128/JVI.02158-10
10.1016/j.ygyno.2009.05.032
10.1016/j.bbrep.2020.100881
10.1073/pnas.97.23.12513
10.1038/s41388-020-01431-8
10.1038/nature12881
10.1016/j.omto.2021.12.011
10.1128/JVI.77.1.673-684.2003
10.1097/CEJ.0b013e328364f273
10.1016/j.cell.2010.06.040
10.1007/s10147-023-02337-7
10.1002/jcp.25739
10.1042/BST0351456
10.5306/wjco.v5.i4.753
10.6061/clinics/2018/e486s
10.1128/jvi.71.5.3853-3863.1997
10.1158/1055-9965.EPI-05-0577
10.1006/viro.1996.0171
10.1371/journal.ppat.1006211
10.1242/jcs.061978
10.1098/rstb.2016.0273
10.3390/v7092862
10.1002/ijc.22089
10.1007/s10156-012-0485-5
10.1016/j.pmedr.2024.102678
10.1186/s12885-018-4165-4
10.1128/JCM.00991-09
10.1371/journal.ppat.1004712
10.1002/jmv.29524
10.3389/fonc.2024.1356581
10.1586/14760584.2014.963561
ContentType Journal Article
Copyright COPYRIGHT 2025 MDPI AG
2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2025 by the authors. 2025
Copyright_xml – notice: COPYRIGHT 2025 MDPI AG
– notice: 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2025 by the authors. 2025
DBID AAYXX
CITATION
NPM
7T7
8FD
8FE
8FH
ABUWG
AFKRA
ATCPS
AZQEC
BBNVY
BENPR
BHPHI
C1K
CCPQU
COVID
DWQXO
FR3
GNUQQ
HCIFZ
LK8
M7P
P64
PATMY
PHGZM
PHGZT
PIMPY
PKEHL
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
PYCSY
7X8
5PM
DOA
DOI 10.3390/microorganisms13051000
DatabaseName CrossRef
PubMed
Industrial and Applied Microbiology Abstracts (Microbiology A)
Technology Research Database
ProQuest SciTech Collection
ProQuest Natural Science Collection
ProQuest Central
ProQuest Central UK/Ireland
Agricultural & Environmental Science Collection
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One
Coronavirus Research Database
ProQuest Central
Engineering Research Database
ProQuest Central Student
SciTech Premium Collection
ProQuest Biological Science Collection
Biological Science Database
Biotechnology and BioEngineering Abstracts
Environmental Science Database
Proquest Central Premium
ProQuest One Academic (New)
Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Environmental Science Collection
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
PubMed
Publicly Available Content Database
ProQuest Central Student
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest Central
ProQuest One Applied & Life Sciences
Natural Science Collection
ProQuest Central Korea
Agricultural & Environmental Science Collection
Biological Science Collection
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Central (New)
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
Coronavirus Research Database
Biological Science Database
ProQuest SciTech Collection
Biotechnology and BioEngineering Abstracts
Environmental Science Collection
ProQuest One Academic UKI Edition
Environmental Science Database
Engineering Research Database
ProQuest One Academic
ProQuest One Academic (New)
MEDLINE - Academic
DatabaseTitleList

MEDLINE - Academic
Publicly Available Content Database
PubMed
CrossRef
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
Public Health
EISSN 2076-2607
ExternalDocumentID oai_doaj_org_article_93f40d0ddd32474e8316ddc7db11f13d
PMC12113743
A842760806
40431173
10_3390_microorganisms13051000
Genre Journal Article
Review
GeographicLocations Romania
Africa
GeographicLocations_xml – name: Romania
– name: Africa
GroupedDBID 53G
5VS
7XC
8FE
8FH
AADQD
AAFWJ
AAHBH
AAYXX
ACPRK
AFKRA
AFPKN
AFRAH
AFZYC
ALMA_UNASSIGNED_HOLDINGS
ATCPS
BBNVY
BENPR
BHPHI
CCPQU
CITATION
ECGQY
GROUPED_DOAJ
GS5
GX1
HCIFZ
HYE
IAO
ITC
KQ8
LK8
M48
M7P
MODMG
M~E
OK1
PATMY
PGMZT
PHGZM
PHGZT
PIMPY
PQGLB
PROAC
PUEGO
PYCSY
RNS
RPM
NPM
PMFND
7T7
8FD
ABUWG
AZQEC
C1K
COVID
DWQXO
FR3
GNUQQ
P64
PKEHL
PQEST
PQQKQ
PQUKI
PRINS
7X8
5PM
ID FETCH-LOGICAL-c525t-15f8358da3323bc49d4c0d0fda71f9ed563bc946e8f2d08f38520e6c23c766133
IEDL.DBID M48
ISSN 2076-2607
IngestDate Wed Aug 27 01:31:35 EDT 2025
Thu Aug 21 18:37:16 EDT 2025
Fri Sep 05 16:00:22 EDT 2025
Fri Jul 18 09:41:45 EDT 2025
Tue Jun 17 21:57:09 EDT 2025
Tue Jun 10 03:41:57 EDT 2025
Sun Jun 01 01:35:20 EDT 2025
Wed Sep 10 05:26:38 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 5
Keywords DNA methylation
miRNA
early proteins
cervical cancer
exosomes
HPV
Language English
License https://creativecommons.org/licenses/by/4.0
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c525t-15f8358da3323bc49d4c0d0fda71f9ed563bc946e8f2d08f38520e6c23c766133
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ORCID 0000-0002-7027-6956
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.3390/microorganisms13051000
PMID 40431173
PQID 3212082708
PQPubID 2032358
ParticipantIDs doaj_primary_oai_doaj_org_article_93f40d0ddd32474e8316ddc7db11f13d
pubmedcentral_primary_oai_pubmedcentral_nih_gov_12113743
proquest_miscellaneous_3212782224
proquest_journals_3212082708
gale_infotracmisc_A842760806
gale_infotracacademiconefile_A842760806
pubmed_primary_40431173
crossref_primary_10_3390_microorganisms13051000
PublicationCentury 2000
PublicationDate 2025-04-27
PublicationDateYYYYMMDD 2025-04-27
PublicationDate_xml – month: 04
  year: 2025
  text: 2025-04-27
  day: 27
PublicationDecade 2020
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
– name: Basel
PublicationTitle Microorganisms (Basel)
PublicationTitleAlternate Microorganisms
PublicationYear 2025
Publisher MDPI AG
MDPI
Publisher_xml – name: MDPI AG
– name: MDPI
References Ivanov (ref_168) 2021; 23
ref_93
ref_136
ref_92
Singh (ref_137) 2017; 28
ref_90
Vink (ref_210) 2020; 147
Vats (ref_95) 2022; 96
You (ref_31) 2018; 15
Console (ref_196) 2018; 488
Mirzaei (ref_183) 2017; 232
ref_130
(ref_202) 2018; 17
Miller (ref_133) 2007; 127
Sasagawa (ref_91) 2012; 18
Fauquet (ref_47) 2004; 324
Vaccarella (ref_15) 2006; 15
DiGiuseppe (ref_112) 2017; 91
Sen (ref_201) 2018; 15
Jiang (ref_119) 2020; 47
Doorbar (ref_75) 2013; 445
ref_127
Khan (ref_186) 2009; 100
Abdullahi (ref_220) 2020; 1
Ju (ref_173) 2014; 12
Chen (ref_144) 2017; 8
ref_124
ref_123
Zheng (ref_165) 2011; 1809
Branca (ref_97) 2004; 122
Ashrafi (ref_88) 2005; 113
Zhang (ref_166) 2017; 8
Chen (ref_72) 2020; 178
Markowitz (ref_217) 2007; 56
Torrisi (ref_44) 2000; 21
ref_158
Molina (ref_69) 2024; 30
Lizano (ref_117) 2014; 45
ref_150
Lovestad (ref_71) 2021; 12
Kusakabe (ref_128) 2023; 114
Burd (ref_233) 2003; 16
Paradkar (ref_142) 2014; 15
Ferns (ref_147) 2016; 4
ref_148
Apt (ref_45) 1996; 224
Zhang (ref_40) 2020; 32
ref_145
Georges (ref_22) 2020; 8
Nguyen (ref_152) 2005; 96
Shen (ref_164) 2020; 248–249
Jefferson (ref_216) 2020; 9
ref_215
ref_218
Wilting (ref_177) 2013; 8
Ohtani (ref_204) 2004; 51
ref_219
Loizzi (ref_94) 2021; 162
Lee (ref_18) 2019; 11
Parsa (ref_203) 2007; 13
Pandey (ref_156) 2009; 114
ref_212
Schmitt (ref_29) 2010; 48
Archambault (ref_56) 2011; 5
Moody (ref_58) 2010; 10
Alsaweed (ref_162) 2015; 12
Brand (ref_116) 2017; 10
Khan (ref_77) 2011; 85
Kusakabe (ref_109) 2023; 28
ref_208
Menges (ref_122) 2006; 66
Park (ref_20) 2014; 35
Breitburd (ref_80) 1993; 101
Hashmi (ref_232) 2020; 12
Forman (ref_6) 2012; 30
Bakkers (ref_28) 2006; 44
Wang (ref_87) 2010; 291
Wilting (ref_176) 2010; 9
ref_238
Favre (ref_42) 1975; 15
White (ref_59) 2001; 276
ref_230
Shalaby (ref_12) 2024; 96
Stanley (ref_43) 2007; 35
Chatterjee (ref_214) 2014; 13
Sui (ref_70) 2020; 20
Song (ref_114) 2017; 38
Sapp (ref_46) 1995; 76
ref_225
ref_103
Clifford (ref_16) 2003; 88
ref_105
Khan (ref_187) 2011; 16
ref_229
ref_228
Berg (ref_52) 1997; 71
Rathi (ref_223) 2018; 2
Bhattacharjee (ref_51) 2022; 174
Veress (ref_155) 2004; 24
White (ref_60) 2003; 278
Kovachev (ref_134) 2021; 14
Gupta (ref_61) 2018; 42
Cogliano (ref_23) 2005; 6
Laimins (ref_172) 2010; 84
Basu (ref_224) 2021; 22
Moreno (ref_160) 2011; 4
Sung (ref_24) 2021; 71
ref_14
Weng (ref_35) 2018; 19
Ong (ref_37) 1993; 67
ref_13
ref_11
Bridgewood (ref_188) 2017; 26
Lee (ref_21) 2012; 13
Saslow (ref_213) 2012; 62
Plummer (ref_211) 2017; 141
ref_17
Sheila (ref_65) 2016; 90
Chaiwongkot (ref_199) 2013; 132
Sadaf (ref_221) 2013; 31
Paaso (ref_153) 2019; 63
Schiffman (ref_10) 2016; 2
Chiantore (ref_193) 2016; 142
Kennedy (ref_104) 2014; 88
Rodon (ref_98) 2013; 10
Chan (ref_129) 2019; 19
Roberts (ref_79) 2003; 77
Harden (ref_194) 2017; 508
Rebolj (ref_138) 2013; 13
Bao (ref_9) 2008; 18
Moon (ref_120) 2004; 5
Ojesina (ref_115) 2014; 506
Clifford (ref_27) 2006; 24
Huang (ref_106) 2024; 31
Nahand (ref_132) 2020; 146
Burdier (ref_200) 2024; 41
Ren (ref_84) 2020; 39
Ganguly (ref_86) 2012; 35
Wu (ref_131) 2016; 37
Aghbash (ref_107) 2023; 30
Kojima (ref_154) 2013; 69
Cheng (ref_170) 2017; 16
Shashikala (ref_234) 2025; 17
Zhang (ref_140) 2018; 22
Liu (ref_102) 2016; 23
Narayan (ref_206) 2003; 2
Cheng (ref_125) 2012; 19
Kim (ref_82) 2009; 30
Costa (ref_19) 2015; 14
Bergvall (ref_53) 2013; 445
Sotlar (ref_32) 2004; 74
(ref_198) 2014; 31
Vink (ref_205) 2021; 149
Filho (ref_209) 2017; 232
Arbyn (ref_239) 2019; 7
Utami (ref_149) 2018; 8
Alenquer (ref_181) 2015; 7
Peng (ref_96) 2024; 31
Ashrafi (ref_89) 2006; 119
Doorbar (ref_76) 1996; 218
ref_174
ref_54
Bosch (ref_26) 2003; 348
ref_179
Clifford (ref_231) 2005; 14
Castle (ref_33) 2005; 97
Yin (ref_207) 2016; 13
ref_180
Ribeiro (ref_113) 2018; 73
Paolini (ref_74) 2021; 40
Oh (ref_101) 2015; 6
Singini (ref_110) 2023; 95
Yam (ref_226) 2017; 18
Ridolfi (ref_139) 2015; 7
Mok (ref_163) 2024; 41
Kaarthigeyan (ref_235) 2012; 33
Akagi (ref_67) 2023; 13
Tian (ref_73) 2022; 24
ref_169
Wang (ref_81) 2009; 83
ref_68
ref_161
Coker (ref_7) 2012; 206
ref_64
Mah (ref_146) 2016; 36
Wang (ref_189) 2017; 14
ref_63
Network (ref_50) 2017; 543
ref_62
Etchart (ref_135) 2006; 24
Dunn (ref_222) 2015; 17
Goodwin (ref_57) 2000; 97
Balaji (ref_111) 2022; 33
Herrera (ref_171) 2014; 19
Jung (ref_100) 2013; 435
Li (ref_182) 2013; 14
MacLaughlin (ref_236) 2019; 28
McIntosh (ref_78) 2010; 123
ref_36
Talora (ref_118) 2005; 305
Singh (ref_227) 2021; 9
ref_34
Kawachi (ref_143) 2018; 109
Stanley (ref_159) 2010; 117
ref_197
Deng (ref_83) 2004; 78
Veeraraghavalu (ref_121) 2005; 79
Clerici (ref_190) 1997; 89
ref_39
Chojnacki (ref_55) 2018; 46
Crook (ref_85) 1991; 67
Storey (ref_157) 1998; 393
Sadeghi (ref_30) 2016; 18
Serrano (ref_48) 2018; 47
Erickson (ref_25) 2013; 208
Gregory (ref_178) 2008; 10
Kalantari (ref_38) 2005; 79
Dhandapani (ref_126) 2007; 102
Bonavita (ref_185) 2018; 172
Baker (ref_41) 1991; 60
Khan (ref_66) 2000; 37
(ref_141) 2014; 5
ref_184
Huarte (ref_195) 2010; 142
ref_1
Wentzensen (ref_237) 2021; 151
Asiaf (ref_3) 2014; 23
ref_2
Ruiz (ref_99) 2016; 529
Gezer (ref_191) 2014; 38
ref_49
Tomita (ref_8) 2011; 6
Hu (ref_108) 2022; 18
Yao (ref_175) 2013; 10
ref_192
Tsang (ref_167) 2011; 30
ref_5
(ref_151) 2013; 131
ref_4
References_xml – volume: 208
  start-page: 169
  year: 2013
  ident: ref_25
  article-title: Human papillomavirus: What every provider should know
  publication-title: Am. J. Obstet. Gynecol.
  doi: 10.1016/j.ajog.2012.09.007
– volume: 17
  start-page: 200
  year: 2018
  ident: ref_202
  article-title: Wnt/β-catenin pathway activation and silencing of the APC gene in HPV-positive human cervical cancer-derived cells
  publication-title: Mol. Med. Rep.
– volume: 172
  start-page: 1022
  year: 2018
  ident: ref_185
  article-title: NK Cells Stimulate Recruitment of CDC1 into the Tumor Microenvironment Promoting Cancer Immune Control
  publication-title: Cell
  doi: 10.1016/j.cell.2018.01.004
– volume: 16
  start-page: 5464
  year: 2017
  ident: ref_170
  article-title: Human papillomavirus E6-regulated microRNA-20b promotes invasion in cervical cancer by targeting tissue inhibitor of metalloproteinase 2
  publication-title: Mol. Med. Rep.
  doi: 10.3892/mmr.2017.7231
– volume: 97
  start-page: 1066
  year: 2005
  ident: ref_33
  article-title: Human papillomavirus type 16 infections and 2-year absolute risk of cervical precancer in women with equivocal or mild cytologic abnormalities
  publication-title: J. Natl. Cancer Inst.
  doi: 10.1093/jnci/dji186
– volume: 305
  start-page: 343
  year: 2005
  ident: ref_118
  article-title: Constitutively active Notch1 induces growth arrest of HPV-positive cervical cancer cells via separate signaling pathways
  publication-title: Exp. Cell Res.
  doi: 10.1016/j.yexcr.2005.01.015
– volume: 40
  start-page: 37
  year: 2021
  ident: ref_74
  article-title: Intrabodies targeting human papillomavirus 16 E6 and E7 oncoproteins for therapy of established HPV associated tumors
  publication-title: J. Exp. Clin. Cancer Res.
  doi: 10.1186/s13046-021-01841-w
– volume: 15
  start-page: 1239
  year: 1975
  ident: ref_42
  article-title: Structural polypeptides of rabbit, bovine, and human papillomaviruses
  publication-title: J. Virol.
  doi: 10.1128/jvi.15.5.1239-1247.1975
– volume: 26
  start-page: 402
  year: 2017
  ident: ref_188
  article-title: IL-36γ has proinflammatory effects on human endothelial cells
  publication-title: Exp. Dermatol.
  doi: 10.1111/exd.13228
– volume: 7
  start-page: 1079
  year: 2015
  ident: ref_139
  article-title: HPV-E7 delivered by engineered exosomes elicits a protective CD8[+] T cell-mediated immune response
  publication-title: Viruses
  doi: 10.3390/v7031079
– volume: 543
  start-page: 378
  year: 2017
  ident: ref_50
  article-title: Integrated genomic and molecular characterization of cervical cancer
  publication-title: Nature
  doi: 10.1038/nature21386
– volume: 47
  start-page: 4587
  year: 2020
  ident: ref_119
  article-title: Role of PI3K/AKT pathway in cancer: The framework of malignant behavior
  publication-title: Mol. Biol. Rep.
  doi: 10.1007/s11033-020-05435-1
– volume: 41
  start-page: 163
  year: 2024
  ident: ref_163
  article-title: miRNAs in pancreatic cancer progression and metastasis
  publication-title: Clin. Exp. Metastasis
  doi: 10.1007/s10585-023-10256-0
– volume: 30
  start-page: 99
  year: 2023
  ident: ref_107
  article-title: The effect of Wnt/β-catenin signaling on PD-1/PDL-1 axis in HPV-related cervical cancer
  publication-title: Oncol. Res.
  doi: 10.32604/or.2022.026776
– volume: 28
  start-page: 244
  year: 2019
  ident: ref_236
  article-title: Trends Over Time in Pap and Pap-HPV Cotesting for Cervical Cancer Screening
  publication-title: J. Womens Health
  doi: 10.1089/jwh.2018.7380
– volume: 2
  start-page: 24
  year: 2003
  ident: ref_206
  article-title: Frequent promoter methylation of CDH1, DAPK, RARB, and HIC1 genes in carcinoma of cervix uteri: Its relationship to clinical outcome
  publication-title: Mol. Cancer
  doi: 10.1186/1476-4598-2-24
– ident: ref_93
  doi: 10.3390/cancers14010193
– volume: 8
  start-page: 3868
  year: 2017
  ident: ref_144
  article-title: Clinical significance of CD163+ and CD68+ tumor-associated macrophages in high-risk HPV-related cervical cancer
  publication-title: J. Cancer
  doi: 10.7150/jca.21444
– volume: 35
  start-page: 1430
  year: 2014
  ident: ref_20
  article-title: Molecular mechanisms of cervical carcinogenesis
  publication-title: Carcinogenesis
– volume: 30
  start-page: 753
  year: 2009
  ident: ref_82
  article-title: Involvement of NF-κB and AP-1 in COX-2 upregulation by human papillomavirus 16 E5 oncoprotein
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgp066
– volume: 4
  start-page: 78
  year: 2016
  ident: ref_147
  article-title: Classical and Non-Classical HLA Class I Aberrations in Primary Cervical Squamous- and Adenocarcinomas and Paired Lymph Node Metastases
  publication-title: J. Immunother. Cancer
  doi: 10.1186/s40425-016-0184-3
– volume: 88
  start-page: 63
  year: 2003
  ident: ref_16
  article-title: Human papillomavirus types in invasive cervical cancer worldwide: A meta-analysis
  publication-title: Br. J. Cancer
  doi: 10.1038/sj.bjc.6600688
– volume: 6
  start-page: 36219
  year: 2015
  ident: ref_101
  article-title: HER2 as a novel therapeutic target for cervical cancer
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.5283
– volume: 69
  start-page: 134
  year: 2013
  ident: ref_154
  article-title: The prevalence of cervical regulatory T cells in HPV-related cervical intraepithelial neoplasia [CIN] correlates inversely with spontaneous regression of CIN
  publication-title: Am. J. Reprod. Immunol.
  doi: 10.1111/aji.12030
– volume: 79
  start-page: 7889
  year: 2005
  ident: ref_121
  article-title: Complementation of human papillomavirus type 16 E6 and E7 by Jagged1-specific Notch1-phosphatidylinositol 3-kinase signaling involves pleiotropic oncogenic functions independent of CBF1; Su [H]; Lag-1 activation
  publication-title: J. Virol.
  doi: 10.1128/JVI.79.12.7889-7898.2005
– volume: 10
  start-page: 593
  year: 2008
  ident: ref_178
  article-title: The miR-200 family and miR-205 regulate epithelial tom esenchymal transition by targeting ZEB1 and SIP1
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb1722
– ident: ref_212
– ident: ref_13
– volume: 51
  start-page: 146
  year: 2004
  ident: ref_204
  article-title: The p16INK4a-RB pathway: Molecular link between cellular senescence and tumor suppression
  publication-title: J. Med. Investig.
  doi: 10.2152/jmi.51.146
– volume: 24
  start-page: S3/26
  year: 2006
  ident: ref_27
  article-title: HPV type-distribution in women with and without cervical neoplastic diseases
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2006.05.026
– volume: 10
  start-page: 143
  year: 2013
  ident: ref_98
  article-title: Development of PI3K inhibitors: Lessons learned from early clinical trials. Nature reviews
  publication-title: Clin. Oncol.
– ident: ref_49
  doi: 10.3389/fmicb.2019.03116
– volume: 278
  start-page: 26765
  year: 2003
  ident: ref_60
  article-title: Inhibition of human papillomavirus DNA replication by small molecule antagonists of the E1–E2 protein interaction
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M303608200
– volume: 63
  start-page: 148
  year: 2019
  ident: ref_153
  article-title: From HPV infection to lesion progression: The role of HLA alleles and host immunity
  publication-title: Acta Cytol.
  doi: 10.1159/000494985
– volume: 12
  start-page: 200221
  year: 2021
  ident: ref_71
  article-title: HPV16 and HPV18 type-specific APOBEC3 and integration profiles in different diagnostic categories of cervical samples
  publication-title: Tumour Virus Res.
  doi: 10.1016/j.tvr.2021.200221
– ident: ref_180
  doi: 10.3390/cells10030668
– ident: ref_228
– volume: 76
  start-page: 2407
  year: 1995
  ident: ref_46
  article-title: Organization of the major and minor capsid proteins in human papillomavirus type 33 virus-like particles
  publication-title: J. Gen. Virol.
  doi: 10.1099/0022-1317-76-9-2407
– volume: 15
  start-page: 11
  year: 2018
  ident: ref_201
  article-title: Modulation of DNA methylation by human papillomavirus E6 and E7 oncoproteins in cervical cancer
  publication-title: Oncol. Lett.
– ident: ref_219
  doi: 10.1097/AOG.0000000000004000
– volume: 348
  start-page: 518
  year: 2003
  ident: ref_26
  article-title: Epidemiologic classification of human papillomavirus types associated with cervical cancer
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa021641
– ident: ref_14
– volume: 9
  start-page: 289
  year: 2021
  ident: ref_227
  article-title: Knowledge regarding cervical cancer and HPV vaccine among medical students: A cross-sectional study
  publication-title: Clin. Epidem Glob. Health
  doi: 10.1016/j.cegh.2020.09.012
– volume: 149
  start-page: 707
  year: 2021
  ident: ref_205
  article-title: Classification of High-Grade Cervical Intraepithelial Neoplasia by P16[Ink4a], Ki-67, HPV E4 and FAM19A4/MiR124-2 Methylation Status Demonstrates Considerable Heterogeneity with Potential Consequences for Management
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.33566
– volume: 18
  start-page: 71
  year: 2008
  ident: ref_9
  article-title: Human papillomavirus type distribution in women from Asia: A meta-analysis
  publication-title: Int. J. Gynecol. Cancer
  doi: 10.1136/ijgc-00009577-200801000-00011
– volume: 17
  start-page: e144
  year: 2015
  ident: ref_222
  article-title: Associations between exposure to and expression of negative opinions about human papillomavirus vaccines on social media: An observational study
  publication-title: J. Med. Internet Res.
  doi: 10.2196/jmir.4343
– volume: 96
  start-page: 452
  year: 2005
  ident: ref_152
  article-title: Immune responses to human papillomavirus in genital tract of women with cervical cancer
  publication-title: Gynecol. Oncol.
  doi: 10.1016/j.ygyno.2004.10.019
– volume: 30
  start-page: 890
  year: 2024
  ident: ref_69
  article-title: HPV integration and cervical cancer: A failed evolutionary viral trait
  publication-title: Trends Mol. Med.
  doi: 10.1016/j.molmed.2024.05.009
– volume: 8
  start-page: 1000462
  year: 2018
  ident: ref_149
  article-title: NK-Cell Count and Its Function in Producing Interferon Gamma Associated with the Cervical Cancer Natural History
  publication-title: Glob. J. Reprod. Med.
– volume: 146
  start-page: 305
  year: 2020
  ident: ref_132
  article-title: Pathogenic role of exosomes and microRNAs in HPV-mediated inflammation and cervical cancer: A review
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.32688
– volume: 14
  start-page: 1002
  year: 2017
  ident: ref_189
  article-title: IL-36γ inhibits differentiation and induces inflammation of keratinocyte via WNT signaling pathway in psoriasis
  publication-title: Int. J. Med. Sci.
  doi: 10.7150/ijms.20809
– ident: ref_179
  doi: 10.1371/journal.pone.0011780
– ident: ref_215
  doi: 10.1038/s41598-025-92861-5
– volume: 15
  start-page: 412
  year: 2018
  ident: ref_31
  article-title: Epidemiological study of high-risk human papillomavirus infection in subjects with abnormal cytological findings in cervical cancer screening
  publication-title: Exp. Ther. Med.
– volume: 13
  start-page: 910
  year: 2023
  ident: ref_67
  article-title: Intratumoral heterogeneity and clonal evolution induced by HPV integration
  publication-title: Cancer Discov.
  doi: 10.1158/2159-8290.CD-22-0900
– volume: 9
  start-page: 167
  year: 2010
  ident: ref_176
  article-title: Methylation-mediated silencing and tumour suppressive function of hsa-miR-124 in cervical cancer
  publication-title: Mol. Cancer
  doi: 10.1186/1476-4598-9-167
– ident: ref_225
  doi: 10.1186/s12889-016-3969-x
– volume: 17
  start-page: 141
  year: 2025
  ident: ref_234
  article-title: Understanding Knowledge Gaps in HPV Infection and Vaccination among Medical Students and Its Implications on Current and Future Trends of HPV Prevention Strategy in India
  publication-title: Int. J. Pharm. Clin. Res.
– volume: 23
  start-page: 109
  year: 2016
  ident: ref_102
  article-title: ERK signaling pathway is involved in HPV-16 E6 but not E7 oncoprotein-induced HIF-1α protein accumulation in NSCLC cells
  publication-title: Oncol. Res.
  doi: 10.3727/096504015X14496932933610
– ident: ref_150
  doi: 10.3390/cells10113104
– volume: 178
  start-page: 104794
  year: 2020
  ident: ref_72
  article-title: In vitro and in vivo growth inhibition of human cervical cancer cells via human papillomavirus E6/E7 mRNAs’ cleavage by CRISPR/Cas13a system
  publication-title: Antivir. Res.
  doi: 10.1016/j.antiviral.2020.104794
– volume: 224
  start-page: 281
  year: 1996
  ident: ref_45
  article-title: High Sp1/Sp3 ratios in epithelial cells during epithelial differentiation and cellular transcription correlate with the activation of the HPV-16 promoter
  publication-title: Virology
  doi: 10.1006/viro.1996.0530
– volume: 10
  start-page: 175
  year: 2013
  ident: ref_175
  article-title: Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in cervical cancer
  publication-title: Virol. J.
  doi: 10.1186/1743-422X-10-175
– volume: 21
  start-page: 168
  year: 2000
  ident: ref_44
  article-title: Colposcopy, cytology and HPV testing in HIV-positive and HIV-negative women
  publication-title: Eur. J. Gynecol. Oncol.
– volume: 32
  start-page: 720
  year: 2020
  ident: ref_40
  article-title: Cervical cancer: Epidemiology, risk factors and screening
  publication-title: Chin. J. Cancer Res.
  doi: 10.21147/j.issn.1000-9604.2020.06.05
– volume: 14
  start-page: 2039
  year: 2021
  ident: ref_134
  article-title: A Review on Inosine Pranobex Immunotherapy for Cervical HPV-Positive Patients
  publication-title: Infect. Drug Resist.
  doi: 10.2147/IDR.S296709
– volume: 18
  start-page: 507
  year: 2022
  ident: ref_108
  article-title: HPV E6/E7 promotes aerobic glycolysis in cervical cancer by regulating IGF2BP2 to stabilize m6A-MYC expression
  publication-title: Int. J. Biol. Sci.
  doi: 10.7150/ijbs.67770
– volume: 46
  start-page: 229
  year: 2018
  ident: ref_55
  article-title: The human papillomavirus DNA helicase E1 binds, stimulates, and confers processivity to cellular DNA polymerase epsilon
  publication-title: Nucl. Acids Res.
  doi: 10.1093/nar/gkx1103
– ident: ref_197
  doi: 10.3390/ijms252312714
– volume: 488
  start-page: 165
  year: 2018
  ident: ref_196
  article-title: Exosomes in inflammation and role as biomarkers
  publication-title: Clin. Chim. Acta
  doi: 10.1016/j.cca.2018.11.009
– volume: 127
  start-page: 262
  year: 2007
  ident: ref_133
  article-title: Human keratinocyte Toll-like receptors promote distinct immune responses
  publication-title: J. Investig. Dermatol.
  doi: 10.1038/sj.jid.5700559
– volume: 56
  start-page: 1
  year: 2007
  ident: ref_217
  article-title: Quadrivalent Human Papillomavirus Vaccine: Recommendations of the Advisory Committee on Immunization Practices [ACIP]
  publication-title: MMWR Recomm. Rep.
– volume: 71
  start-page: 209
  year: 2021
  ident: ref_24
  article-title: Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
  publication-title: CA Cancer J. Clin.
  doi: 10.3322/caac.21660
– volume: 232
  start-page: 48
  year: 2017
  ident: ref_209
  article-title: Methylation at 3’LCR of HPV16 can be affected by patient age and disruption of E1 or E2 genes
  publication-title: Virus Res.
  doi: 10.1016/j.virusres.2017.01.022
– volume: 67
  start-page: 6424
  year: 1993
  ident: ref_37
  article-title: Evolution of human papillomavirus type 18: An ancient phylogenetic root in Africa and intratype diversity reflect coevolution with human ethnic groups
  publication-title: J. Virol.
  doi: 10.1128/jvi.67.11.6424-6431.1993
– volume: 276
  start-page: 22426
  year: 2001
  ident: ref_59
  article-title: Characterization of recombinant HPV6 and 11 E1 helicases: Effect of ATP on the interaction of E1 with E2 and mapping of a minimal helicase domain
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M101932200
– volume: 13
  start-page: 29
  year: 2013
  ident: ref_138
  article-title: Immunosuppression and risk of cervical cancer
  publication-title: Expert Rev Anticancer Ther.
  doi: 10.1586/era.12.159
– ident: ref_208
  doi: 10.3892/br.2021.1436
– volume: 23
  start-page: 541
  year: 2021
  ident: ref_168
  article-title: Detection of Cervical Lesions and Cancer in Air-Dried Cytologic Smears by Combined Analysis of mRNA and miRNA Expression Levels
  publication-title: J. Mol. Diagn.
  doi: 10.1016/j.jmoldx.2021.01.016
– volume: 151
  start-page: 106596
  year: 2021
  ident: ref_237
  article-title: Impact of COVID-19 on cervical cancer screening: Challenges and opportunities to improve resilience and reduce disparities
  publication-title: Prev. Med.
  doi: 10.1016/j.ypmed.2021.106596
– volume: 62
  start-page: 147
  year: 2012
  ident: ref_213
  article-title: American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer
  publication-title: CA Cancer J. Clin.
  doi: 10.3322/caac.21139
– volume: 45
  start-page: 525
  year: 2014
  ident: ref_117
  article-title: The role of signaling pathways in cervical cancer and molecular therapeutic targets
  publication-title: Arch. Med. Res.
  doi: 10.1016/j.arcmed.2014.10.008
– volume: 33
  start-page: 7
  year: 2012
  ident: ref_235
  article-title: Cervical cancer in India and HPV vaccination
  publication-title: Indian. J. Med. Paediatr. Oncol.
  doi: 10.4103/0971-5851.96961
– volume: 6
  start-page: 33
  year: 2011
  ident: ref_8
  article-title: The molecular basis of cervical cancer progression
  publication-title: Infect. Agents Cancer
– volume: 19
  start-page: 580
  year: 2012
  ident: ref_125
  article-title: Influence of HPV16 E6/7 on the expression of FGF2 and FGFR type B in cervical carcinogenesis
  publication-title: Reprod. Sci.
  doi: 10.1177/1933719111432874
– volume: 36
  start-page: 131
  year: 2016
  ident: ref_146
  article-title: Metabolic Regulation of Natural Killer Cell IFN- Production
  publication-title: Crit. Rev. Immunol.
  doi: 10.1615/CritRevImmunol.2016017387
– volume: 1809
  start-page: 668
  year: 2011
  ident: ref_165
  article-title: Regulation of cellular miRNA expression by human papillomaviruses
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbagrm.2011.05.005
– volume: 142
  start-page: 1751
  year: 2016
  ident: ref_193
  article-title: Human papillomavirus E6 and E7 oncoproteins affect the expression of cancer-related microRNAs: Additional evidence in HPV-induced tumorigenesis
  publication-title: J. Cancer Res. Clin. Oncol.
  doi: 10.1007/s00432-016-2189-1
– volume: 13
  start-page: 60
  year: 2016
  ident: ref_207
  article-title: Serine/threonine kinases 31[STK31] may be a novel cellular target gene for the HPV16 oncogene E7 with potential as a DNA hypomethylation biomarker in cervical cancer
  publication-title: Virol. J.
  doi: 10.1186/s12985-016-0515-5
– volume: 14
  start-page: 1157
  year: 2005
  ident: ref_231
  article-title: Distribution of human papillomavirus genotypes in low-grade cervical lesions: Comparison by geographical regions and with cervical cancer
  publication-title: Cancer Epidemiol. Biomark. Prev.
  doi: 10.1158/1055-9965.EPI-04-0812
– ident: ref_145
– volume: 20
  start-page: 1752
  year: 2020
  ident: ref_70
  article-title: Association between APOBEC3s and HPV16 E2 gene hypermutation in Uygur females with cervical cancer
  publication-title: Oncol. Lett.
  doi: 10.3892/ol.2020.11697
– volume: 1
  start-page: CD011895
  year: 2020
  ident: ref_220
  article-title: Improving vaccination uptake among adolescents
  publication-title: Cochrane Database Syst. Rev.
– volume: 141
  start-page: 664
  year: 2017
  ident: ref_211
  article-title: Worldwide burden of cancer attributable to HPV by site, country and HPV type
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.30716
– ident: ref_130
  doi: 10.1038/srep05750
– volume: 13
  start-page: 84
  year: 2007
  ident: ref_203
  article-title: Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma
  publication-title: Nat. Med.
  doi: 10.1038/nm1517
– volume: 9
  start-page: 43
  year: 2020
  ident: ref_216
  article-title: Benefits and harms of the human papillomavirus (HPV) vaccines: Systematic review with meta-analyses of trial data from clinical study reports
  publication-title: Syst. Rev.
  doi: 10.1186/s13643-019-0983-y
– volume: 90
  start-page: 8384
  year: 2016
  ident: ref_65
  article-title: Graham Human Papillomavirus E2 Protein: Linking Replication, Transcription, and RNA Processing
  publication-title: J. Virol.
  doi: 10.1128/JVI.00502-16
– volume: 96
  start-page: e0150321
  year: 2022
  ident: ref_95
  article-title: Loss of the E6AP ubiquitin ligase induces p53-dependent phosphorylation of HPV-18 E6 in cells derived from cervical cancer
  publication-title: J. Virol.
  doi: 10.1128/jvi.01503-21
– volume: 31
  start-page: 9
  year: 2024
  ident: ref_96
  article-title: HPV E6/E7: Insights into their regulatory role and mechanism in signaling pathways in HPV-associated tumor
  publication-title: Cancer Gene Ther.
  doi: 10.1038/s41417-023-00682-3
– volume: 101
  start-page: 843
  year: 1993
  ident: ref_80
  article-title: Cytopathic effect in human papillomavirus type 1–Induced inclusion warts: In vitro analysis of the contribution of two forms of the viral E4 protein
  publication-title: J. Investig. Dermatol.
  doi: 10.1111/1523-1747.ep12371705
– volume: 8
  start-page: 220
  year: 2013
  ident: ref_177
  article-title: Methylation-mediated transcriptional repression of microRNAs during cervical carcinogenesis
  publication-title: Epigenetics
  doi: 10.4161/epi.23605
– volume: 14
  start-page: 793
  year: 2013
  ident: ref_182
  article-title: Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2647
– volume: 30
  start-page: F12
  year: 2012
  ident: ref_6
  article-title: Global burden of human papillomavirus and related diseases
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2012.07.055
– ident: ref_105
  doi: 10.3389/fonc.2021.629350
– volume: 393
  start-page: 229
  year: 1998
  ident: ref_157
  article-title: Role of a p53 polymorphism in the development of human papillomavirus-associated cancer
  publication-title: Nature
  doi: 10.1038/30400
– ident: ref_169
  doi: 10.1371/journal.pone.0021646
– ident: ref_2
– volume: 10
  start-page: 550
  year: 2010
  ident: ref_58
  article-title: Human papillomavirus oncoproteins: Pathways to transformation
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc2886
– volume: 38
  start-page: 1246
  year: 2017
  ident: ref_114
  article-title: Effects of Src on cervical cancer cells proliferation and apoptosis through ERK signal transduction pathway
  publication-title: Zhonghua Liu Xing Bing Xue Za Zhi Zhonghua Liuxingbingxue Zazhi
– volume: 74
  start-page: 107
  year: 2004
  ident: ref_32
  article-title: Detection of high-risk human papillomavirus E6 and E7 oncogene transcripts in cervical scrapes by nested RT-polymerase chain reaction
  publication-title: J. Med. Virol.
  doi: 10.1002/jmv.20153
– volume: 5
  start-page: 80
  year: 2011
  ident: ref_56
  article-title: Small molecule inhibitors of human papillomavirus protein-protein interactions
  publication-title: Open Virol. J.
  doi: 10.2174/1874357901105010080
– volume: 14
  start-page: 14672
  year: 2015
  ident: ref_19
  article-title: Genetic basis of cervical cancer development
  publication-title: Genet. Mol. Res.
– volume: 147
  start-page: 1215
  year: 2020
  ident: ref_210
  article-title: FAM19A4/MiR124-2 Methylation in Invasive Cervical Cancer: A Retrospective Cross-Sectional Worldwide Study
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.32614
– volume: 435
  start-page: 339
  year: 2013
  ident: ref_100
  article-title: A novel function of HPV16-E6/E7 in epithelial–mesenchymal transition
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2013.04.060
– volume: 30
  start-page: 2401
  year: 2011
  ident: ref_167
  article-title: Human papillomavirus type 16 E6 induces cervical cancer cell migration through the p53/microRNA-23b/urokinase-type plasminogen activator pathway
  publication-title: Oncogene
  doi: 10.1038/onc.2010.613
– ident: ref_4
  doi: 10.1101/144576
– ident: ref_90
  doi: 10.3390/ijms252312991
– ident: ref_36
  doi: 10.1371/journal.pone.0072565
– volume: 67
  start-page: 547
  year: 1991
  ident: ref_85
  article-title: Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation
  publication-title: Cell
  doi: 10.1016/0092-8674(91)90529-8
– ident: ref_148
  doi: 10.1186/1471-2407-14-957
– ident: ref_39
– volume: 31
  start-page: 4293
  year: 2013
  ident: ref_221
  article-title: A systematic review of interventions for reducingparental vaccine refusal and vaccine hesitancy
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2013.07.013
– ident: ref_1
– volume: 100
  start-page: 1073
  year: 2009
  ident: ref_186
  article-title: Extracellular, cell-permeable survivin inhibits apoptosis while promoting proliferative and metastatic potential
  publication-title: Br. J. Cancer
  doi: 10.1038/sj.bjc.6604978
– volume: 19
  start-page: 6263
  year: 2014
  ident: ref_171
  article-title: MicroRNAs in cervical cancer: Evidences for a miRNA profile deregulated by HPV and its impact on radio-resistance
  publication-title: Molecules
  doi: 10.3390/molecules19056263
– volume: 28
  start-page: 133
  year: 2017
  ident: ref_137
  article-title: Functional characterization of CD4 and CD8 T cell responses among human papillomavirus infected patients with anogenital warts
  publication-title: Virus Dis.
– volume: 42
  start-page: 161
  year: 2018
  ident: ref_61
  article-title: HPV: Molecular pathways and targets
  publication-title: Curr. Probl. Cancer
  doi: 10.1016/j.currproblcancer.2018.03.003
– volume: 19
  start-page: 1800149
  year: 2019
  ident: ref_129
  article-title: Exosomes in inflammation and inflammatory disease
  publication-title: Proteomics
  doi: 10.1002/pmic.201800149
– volume: 529
  start-page: 541
  year: 2016
  ident: ref_99
  article-title: Structure of the E6/ E6AP/p53 complex required for HPV-mediated degradation of p53
  publication-title: Nature
  doi: 10.1038/nature16481
– volume: 2
  start-page: 16086
  year: 2016
  ident: ref_10
  article-title: Carcinogenic human papillomavirus infection
  publication-title: Nat. Rev. Dis. Primers
  doi: 10.1038/nrdp.2016.86
– volume: 37
  start-page: 477
  year: 2000
  ident: ref_66
  article-title: Plasmid rolling-circle replication: Recent developments
  publication-title: Mol. Microbiol.
  doi: 10.1046/j.1365-2958.2000.02001.x
– volume: 88
  start-page: 11965
  year: 2014
  ident: ref_104
  article-title: Inactivation of the human papillomavirus E6 or E7 gene in cervical carcinoma cells by using a bacterial CRISPR/Cas RNA-guided endonuclease
  publication-title: J. Virol.
  doi: 10.1128/JVI.01879-14
– volume: 102
  start-page: 522
  year: 2007
  ident: ref_126
  article-title: Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP-1 and NFκB transcription factors
  publication-title: J. Neurochem.
  doi: 10.1111/j.1471-4159.2007.04633.x
– volume: 2
  start-page: 62
  year: 2018
  ident: ref_223
  article-title: HPV Vaccine Scenario in India—A Short Report
  publication-title: Madridge J. Vaccines
  doi: 10.18689/mjv-1000113
– volume: 22
  start-page: 1518
  year: 2021
  ident: ref_224
  article-title: Vaccine efficacy against persistent human papillomavirus [HPV] 16/18 infection at 10 years after one, two, and three doses of quadrivalent HPV vaccine in girls in India: A multi-centre, prospective, cohort study
  publication-title: Lancet Oncol.
  doi: 10.1016/S1470-2045(21)00453-8
– volume: 16
  start-page: 1
  year: 2003
  ident: ref_233
  article-title: Human papillomavirus and cervical cancer
  publication-title: Clin. Microbiol. Rev.
  doi: 10.1128/CMR.16.1.1-17.2003
– volume: 13
  start-page: 5489
  year: 2012
  ident: ref_21
  article-title: HPV and its role in cervical cancer
  publication-title: Asian Pac. J. Cancer Prev.
– volume: 7
  start-page: e688
  year: 2019
  ident: ref_239
  article-title: HPV-based cervical cancer screening, including self-sampling, versus screening with cytology in Argentina
  publication-title: Lancet Glob. Health
  doi: 10.1016/S2214-109X(19)30067-1
– volume: 445
  start-page: 80
  year: 2013
  ident: ref_75
  article-title: The E4 protein; structure, function and patterns of expression
  publication-title: Virology
  doi: 10.1016/j.virol.2013.07.008
– ident: ref_103
  doi: 10.1006/scbi.1996.0042
– ident: ref_123
  doi: 10.1038/s41598-023-42022-3
– volume: 6
  start-page: 38
  year: 2005
  ident: ref_23
  article-title: Carcinogenicity of human papillomaviruses
  publication-title: Lancet Oncol.
  doi: 10.1016/S1470-2045(05)70086-3
– volume: 15
  start-page: 3851
  year: 2014
  ident: ref_142
  article-title: Role of cytokines in genesis, progression and prognosis of cervical cancer
  publication-title: Asian Pac. J. Cancer Prev. APJCP
  doi: 10.7314/APJCP.2014.15.9.3851
– volume: 206
  start-page: 965
  year: 2012
  ident: ref_7
  article-title: Clinical aspects of cervical cancer and HPV infection
  publication-title: J. Infect. Dis.
– ident: ref_54
  doi: 10.1038/s41598-019-49886-4
– volume: 131
  start-page: 480
  year: 2013
  ident: ref_151
  article-title: Immune responses against virus and tumor in cervical carcinogenesis: Treatment strategies for avoiding the HPV-induced immune escape
  publication-title: Gynecol. Oncol.
  doi: 10.1016/j.ygyno.2013.08.025
– volume: 445
  start-page: 35
  year: 2013
  ident: ref_53
  article-title: The E1 proteins
  publication-title: Virology
  doi: 10.1016/j.virol.2013.07.020
– volume: 66
  start-page: 5555
  year: 2006
  ident: ref_122
  article-title: Human papillomavirus type 16 E7 up-regulates AKT activity through the retinoblastoma protein
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-06-0499
– ident: ref_63
  doi: 10.1186/s12929-019-0520-2
– volume: 162
  start-page: 103343
  year: 2021
  ident: ref_94
  article-title: Dynamic crosstalk within the tumor microenvironment of uterine cervical carcinoma: Baseline network, iatrogenic alterations, and translational implications
  publication-title: Crit. Rev. Oncol. Hematol.
  doi: 10.1016/j.critrevonc.2021.103343
– volume: 79
  start-page: 6565
  year: 2005
  ident: ref_38
  article-title: Papillomavirus Subtypes Are Natural and Old Taxa: Phylogeny of Human Papillomavirus Types 44 and 55 and 68a and -b
  publication-title: J. Virol.
  doi: 10.1128/JVI.79.10.6565-6569.2005
– volume: 109
  start-page: 863
  year: 2018
  ident: ref_143
  article-title: Tumor-associated CD204+ M2 macrophages are unfavorable prognostic indicators in uterine cervical adenocarcinoma
  publication-title: Cancer Sci.
  doi: 10.1111/cas.13476
– volume: 4
  start-page: 369
  year: 2011
  ident: ref_160
  article-title: IL-10 expression is regulated by HPV E2 protein in cervical cancer cells
  publication-title: Mol. Med. Rep.
– volume: 47
  start-page: 14
  year: 2018
  ident: ref_48
  article-title: Epidemiology and burden of HPV-related disease
  publication-title: Best Pract. Res. Clin. Obs. Gynaecol.
  doi: 10.1016/j.bpobgyn.2017.08.006
– volume: 117
  start-page: S5
  year: 2010
  ident: ref_159
  article-title: Pathology and epidemiology of HPV infection in females
  publication-title: Gynecol. Oncol.
  doi: 10.1016/j.ygyno.2010.01.024
– volume: 174
  start-page: 103675
  year: 2022
  ident: ref_51
  article-title: Mechanistic role of HPV-associated early proteins in cervical cancer: Molecular pathways and targeted therapeutic strategies
  publication-title: Crit. Rev. Oncol. Hematol.
  doi: 10.1016/j.critrevonc.2022.103675
– volume: 12
  start-page: e12293
  year: 2020
  ident: ref_232
  article-title: Comparison of Liquid-Based Cytology and Conventional Papanicolaou Smear for Cervical Cancer Screening: An Experience from Pakistan
  publication-title: Cureus
– ident: ref_161
  doi: 10.3389/fcell.2024.1397945
– volume: 91
  start-page: 10
  year: 2017
  ident: ref_112
  article-title: Human papillomavirus major capsid protein L1 remains associated with the incoming viral genome throughout the entry process
  publication-title: J Virol.
  doi: 10.1128/JVI.00537-17
– volume: 24
  start-page: 191
  year: 2006
  ident: ref_135
  article-title: Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo
  publication-title: Immunity
  doi: 10.1016/j.immuni.2006.01.005
– volume: 10
  start-page: eaag1064
  year: 2017
  ident: ref_116
  article-title: The receptor tyrosine kinase AXL mediates nuclear translocation of the epidermal growth factor receptor
  publication-title: Sci. Signal.
  doi: 10.1126/scisignal.aag1064
– volume: 113
  start-page: 276
  year: 2005
  ident: ref_88
  article-title: E5 protein of human papillomavirus type 16 selectively downregulates surface HLA class I
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.20558
– volume: 8
  start-page: 96323
  year: 2017
  ident: ref_166
  article-title: Direct HPV E6/Myc interactions induce histone modifications, Pol II phosphorylation, and hTERT promoter activation
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.22036
– volume: 8
  start-page: e180
  year: 2020
  ident: ref_22
  article-title: Global burden of cancer attributable to infections in 2018: A worldwide incidence analysis
  publication-title: Lancet Glob. Health
  doi: 10.1016/S2214-109X(19)30488-7
– volume: 37
  start-page: 12169
  year: 2016
  ident: ref_131
  article-title: Exosomes derived from gastric cancer cells activate NF-κB pathway in macrophages to promote cancer progression
  publication-title: Tumor Biol.
  doi: 10.1007/s13277-016-5071-5
– volume: 5
  start-page: 691
  year: 2004
  ident: ref_120
  article-title: WNT and β-catenin signalling: Diseases and therapies
  publication-title: Nat. Rev. Gen.
  doi: 10.1038/nrg1427
– ident: ref_11
  doi: 10.3390/v10020080
– ident: ref_184
  doi: 10.3390/v9080211
– volume: 84
  start-page: 5212
  year: 2010
  ident: ref_172
  article-title: Human papillomaviruses modulate expression of microRNA 203 upon epithelial differentiation to control levels of p63 proteins
  publication-title: J. Virol.
  doi: 10.1128/JVI.00078-10
– volume: 31
  start-page: 78
  year: 2024
  ident: ref_106
  article-title: Activating STING/TBK1 suppresses tumor growth via degrading HPV16/18 E7 oncoproteins in cervical cancer
  publication-title: Cell Death Differ.
  doi: 10.1038/s41418-023-01242-w
– ident: ref_158
  doi: 10.3390/ijerph19053114
– volume: 19
  start-page: 1102
  year: 2018
  ident: ref_35
  article-title: Genome-wide discovery of viral microRNAs based on phylogenetic analysis and structural evolution of various human papillomavirus subtypes
  publication-title: Brief. Bioinform.
– volume: 31
  start-page: 2467
  year: 2014
  ident: ref_198
  article-title: Human papilloma virus, DNA methylation and microRNA expression in cervical cancer
  publication-title: Oncol. Rep.
  doi: 10.3892/or.2014.3142
– volume: 508
  start-page: 63
  year: 2017
  ident: ref_194
  article-title: Human papillomavirus 16 E6 and E7 oncoprotein expression alters microRNA expression in extracellular vesicles
  publication-title: Virology
  doi: 10.1016/j.virol.2017.05.005
– ident: ref_174
  doi: 10.1371/journal.pone.0234873
– volume: 12
  start-page: 86
  year: 2014
  ident: ref_173
  article-title: Maintenance of the stemness in CD44[+] HCT-15 and HCT-116 human colon cancer cells requires miR-203 suppression
  publication-title: Stem Cell Res.
  doi: 10.1016/j.scr.2013.09.011
– volume: 44
  start-page: 3122
  year: 2006
  ident: ref_28
  article-title: Evaluation of the SPF10-INNO LiPA human papillomavirus [HPV] genotyping test and the Roche Linear Array HPV genotyping test
  publication-title: J. Clin. Microbiol.
  doi: 10.1128/JCM.00517-06
– volume: 60
  start-page: 1445
  year: 1991
  ident: ref_41
  article-title: Structures of bovine and human papillomaviruses. Analysis by cryoelectron microscopy and three-dimensional image reconstruction
  publication-title: Biophys. J.
  doi: 10.1016/S0006-3495(91)82181-6
– volume: 132
  start-page: 2087
  year: 2013
  ident: ref_199
  article-title: Differential methylation of E2 binding sites in episomal and integrated HPV 16 genomes in preinvasive and invasive cervical lesions
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.27906
– volume: 114
  start-page: 885
  year: 2023
  ident: ref_128
  article-title: Cells with stem-like properties are associated with the development of HPV18-positive cervical cancer
  publication-title: Cancer Sci.
  doi: 10.1111/cas.15664
– volume: 291
  start-page: 67
  year: 2010
  ident: ref_87
  article-title: Selective targeting of HPV-16 E6/E7 in cervical cancer cells with a potent oncolytic adenovirus and its enhanced effect with radiotherapy in vitro and vivo
  publication-title: Cancer Lett.
  doi: 10.1016/j.canlet.2009.09.022
– ident: ref_124
  doi: 10.3390/v12090977
– volume: 324
  start-page: 17
  year: 2004
  ident: ref_47
  article-title: Classification of papillomaviruses
  publication-title: Virology
  doi: 10.1016/j.virol.2004.03.033
– ident: ref_5
  doi: 10.1042/BSR20171268
– ident: ref_62
  doi: 10.7150/ijbs.21547
– volume: 95
  start-page: e27900
  year: 2023
  ident: ref_110
  article-title: Usefulness of high-risk HPV early oncoprotein [E6 and E7] serological markers in the detection of cervical cancer: A systematic review and meta-analysis
  publication-title: J. Med. Virol.
  doi: 10.1002/jmv.27900
– volume: 24
  start-page: 245
  year: 2004
  ident: ref_155
  article-title: IL-10 promoter nt -1082A/G polymorphism and human papillomavirus infection in cytologic abnormalities of the uterine cervix
  publication-title: J. Interferon. Cytokine. Res.
  doi: 10.1089/107999004323034114
– volume: 248–249
  start-page: 25
  year: 2020
  ident: ref_164
  article-title: Potential role of microRNAs in the treatment and diagnosis of cervical cancer
  publication-title: Cancer Genet.
  doi: 10.1016/j.cancergen.2020.09.003
– volume: 11
  start-page: 529
  year: 2019
  ident: ref_18
  article-title: The risk factors and clinical outcomes of cervical cancer patients with HPV infections
  publication-title: Cancer Manag. Res.
– volume: 78
  start-page: 13954
  year: 2004
  ident: ref_83
  article-title: Cyclin/CDK regulates the nucleocytoplasmic localization of the human papillomavirus E1 DNA helicase
  publication-title: J. Virol.
  doi: 10.1128/JVI.78.24.13954-13965.2004
– volume: 89
  start-page: 245
  year: 1997
  ident: ref_190
  article-title: Cytokine production patterns in cervical intraepithelial neoplasia: Association with human papillomavirus infection
  publication-title: J. Natl. Cancer Inst.
  doi: 10.1093/jnci/89.3.245
– volume: 16
  start-page: 1
  year: 2011
  ident: ref_187
  article-title: Survivin is released from cancer cells via exosomes
  publication-title: Apoptosis Int. J. Program. Cell Death
  doi: 10.1007/s10495-010-0534-4
– ident: ref_136
  doi: 10.3390/v9090254
– volume: 35
  start-page: 67
  year: 2012
  ident: ref_86
  article-title: Human papillomavirus-16 E5 protein: Oncogenic role and therapeutic value
  publication-title: Cell. Oncol.
  doi: 10.1007/s13402-011-0069-x
– volume: 122
  start-page: 902
  year: 2004
  ident: ref_97
  article-title: Activation of the ERK/MAP kinase pathway in cervical intraepithelial neoplasia is related to grade of the lesion but not to high-risk human papillomavirus, virus clearance, or prognosis in cervical cancer
  publication-title: Am. J. Clin. Pathol.
  doi: 10.1309/VQXFT880JXC7QD2W
– volume: 38
  start-page: 1076
  year: 2014
  ident: ref_191
  article-title: Long non-coding RNAs with low expression levels in cells are enriched in secreted exosomes
  publication-title: Cell Biol. Int.
  doi: 10.1002/cbin.10301
– volume: 83
  start-page: 3668
  year: 2009
  ident: ref_81
  article-title: Phosphorylation of the human papillomavirus type 16 E1^ E4 protein at T57 by ERK triggers a structural change that enhances keratin binding and protein stability
  publication-title: J. Virol.
  doi: 10.1128/JVI.02063-08
– ident: ref_17
– volume: 12
  start-page: 13981
  year: 2015
  ident: ref_162
  article-title: MicroRNAs in breastmilk and the lactating breast: Potential immunoprotectors and developmental regulators for the infant and the mother
  publication-title: Int. J. Environ. Res. Public Health
  doi: 10.3390/ijerph121113981
– volume: 85
  start-page: 9984
  year: 2011
  ident: ref_77
  article-title: Role of calpain in the formation of human papillomavirus type 16 E1^ E4 amyloid fibers and reorganization of the keratin network
  publication-title: J. Virol.
  doi: 10.1128/JVI.02158-10
– volume: 114
  start-page: 501
  year: 2009
  ident: ref_156
  article-title: Impact of toll-like receptors [TLR] 4 gene polymorphisms in susceptibility of cervical cancer in North Indian women
  publication-title: Gynecol. Oncol.
  doi: 10.1016/j.ygyno.2009.05.032
– ident: ref_64
  doi: 10.1016/j.bbrep.2020.100881
– volume: 97
  start-page: 12513
  year: 2000
  ident: ref_57
  article-title: Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.97.23.12513
– volume: 39
  start-page: 6327
  year: 2020
  ident: ref_84
  article-title: HPV E2, E4, E5 drive alternative carcinogenic pathways in HPV positive cancers
  publication-title: Oncogene
  doi: 10.1038/s41388-020-01431-8
– volume: 506
  start-page: 371
  year: 2014
  ident: ref_115
  article-title: Landscape of genomic alterations in cervical carcinomas
  publication-title: Nature
  doi: 10.1038/nature12881
– volume: 24
  start-page: 171
  year: 2022
  ident: ref_73
  article-title: Gene knock-out chain reaction enables high disruption efficiency of HPV18 E6/E7 genes in cervical cancer cells
  publication-title: Mol. Ther. Oncolytics
  doi: 10.1016/j.omto.2021.12.011
– volume: 33
  start-page: 322
  year: 2022
  ident: ref_111
  article-title: Potential role of human papillomavirus proteins associated with the development of cancer
  publication-title: Virus Dis.
– volume: 77
  start-page: 673
  year: 2003
  ident: ref_79
  article-title: The ND10 component promyelocytic leukemia protein relocates to human papillomavirus type 1 E4 intranuclear inclusion bodies in cultured keratinocytes and in warts
  publication-title: J. Virol.
  doi: 10.1128/JVI.77.1.673-684.2003
– ident: ref_34
– volume: 23
  start-page: 206
  year: 2014
  ident: ref_3
  article-title: Review of the current knowledge on the epidemiology, pathogenesis, and prevention of human papillomavirus infection
  publication-title: Eur. J. Cancer Prev.
  doi: 10.1097/CEJ.0b013e328364f273
– ident: ref_218
– volume: 142
  start-page: 409
  year: 2010
  ident: ref_195
  article-title: A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response
  publication-title: Cell
  doi: 10.1016/j.cell.2010.06.040
– ident: ref_230
– volume: 18
  start-page: 1689
  year: 2017
  ident: ref_226
  article-title: A Cross-Sectional Study on Knowledge, Attitude and Practice related to Human Papillomavirus Vaccination for Cervical Cancer Prevention between Medical and Non-Medical Students in Hong Kong
  publication-title: Asian Pac. J. Cancer Prev.
– volume: 28
  start-page: 965
  year: 2023
  ident: ref_109
  article-title: Carcinogenesis and management of human papillomavirus-associated cervical cancer
  publication-title: Int. J. Clin. Oncol.
  doi: 10.1007/s10147-023-02337-7
– volume: 18
  start-page: e24458
  year: 2016
  ident: ref_30
  article-title: Distribution of Human Papillomavirus Genotypes in Iranian Women According to the Severity of the Cervical Lesion
  publication-title: Iran. Red. Crescent Med. J.
– volume: 232
  start-page: 3251
  year: 2017
  ident: ref_183
  article-title: Diagnostic and Therapeutic Potential of Exosomes in Cancer: The Beginning of a New Tale?
  publication-title: J. Cell. Physiol.
  doi: 10.1002/jcp.25739
– volume: 35
  start-page: 1456
  year: 2007
  ident: ref_43
  article-title: HPV: From infection to cancer
  publication-title: Biochem. Soc. Trans.
  doi: 10.1042/BST0351456
– volume: 5
  start-page: 753
  year: 2014
  ident: ref_141
  article-title: Role of IL-10 and TGF-β1 in local immunosuppression in HPV-associated cervical neoplasia
  publication-title: World J. Clin. Oncol.
  doi: 10.5306/wjco.v5.i4.753
– volume: 22
  start-page: 3719
  year: 2018
  ident: ref_140
  article-title: MicroRNA-155 regulates cervical cancer via inducing Th17/Treg imbalance
  publication-title: Eur. Rev. Med. Pharmacol. Sci.
– volume: 73
  start-page: e486s
  year: 2018
  ident: ref_113
  article-title: Regulation of HPV transcription
  publication-title: Clinics
  doi: 10.6061/clinics/2018/e486s
– volume: 71
  start-page: 3853
  year: 1997
  ident: ref_52
  article-title: Functional interactions between papillomavirus E1 and E2 proteins
  publication-title: J. Virol.
  doi: 10.1128/jvi.71.5.3853-3863.1997
– volume: 15
  start-page: 326
  year: 2006
  ident: ref_15
  article-title: Sexual Behavior, Condom Use, and Human Papillomavirus: Pooled Analysis of the IARC Human Papillomavirus Prevalence Surveys
  publication-title: Cancer Epidemiol. Biomark. Prev.
  doi: 10.1158/1055-9965.EPI-05-0577
– volume: 218
  start-page: 114
  year: 1996
  ident: ref_76
  article-title: Analysis of HPV1 E4 complexes and their association with keratinsin vivo
  publication-title: Virology
  doi: 10.1006/viro.1996.0171
– ident: ref_229
– ident: ref_68
  doi: 10.1371/journal.ppat.1006211
– volume: 123
  start-page: 2810
  year: 2010
  ident: ref_78
  article-title: E1^E4-mediated keratin phosphorylation and ubiquitylation: Amechanism for keratin depletion in HPV16-infected epithelium
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.061978
– ident: ref_127
  doi: 10.1098/rstb.2016.0273
– volume: 7
  start-page: 5066
  year: 2015
  ident: ref_181
  article-title: Exosome biogenesis, regulation, and function in viral infection
  publication-title: Viruses
  doi: 10.3390/v7092862
– volume: 119
  start-page: 2105
  year: 2006
  ident: ref_89
  article-title: E5 protein of human papillomavirus 16 downregulates HLA class Iand interacts with the heavy chain via its first hydrophobic domain
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.22089
– volume: 18
  start-page: 807
  year: 2012
  ident: ref_91
  article-title: Immune responses against human papillomavirus [HPV] infection and evasion of host defense in cervical cancer
  publication-title: J. Infect. Chemother.
  doi: 10.1007/s10156-012-0485-5
– volume: 41
  start-page: 102678
  year: 2024
  ident: ref_200
  article-title: DNA methylation as a triage tool for cervical cancer screening—A meeting report
  publication-title: Prev. Med. Rep.
  doi: 10.1016/j.pmedr.2024.102678
– ident: ref_238
  doi: 10.1186/s12885-018-4165-4
– volume: 48
  start-page: 143
  year: 2010
  ident: ref_29
  article-title: Abundance of multiple high-risk human papillomavirus [HPV] infections found in cervical cells analyzed by use of an ultrasensitive HPV genotyping assay
  publication-title: J. Clin. Microbiol.
  doi: 10.1128/JCM.00991-09
– ident: ref_192
  doi: 10.1371/journal.ppat.1004712
– volume: 96
  start-page: e29524
  year: 2024
  ident: ref_12
  article-title: Correlation between high-risk HPV infection and p16/Ki-67 abnormalities in Pap samples in a South Eastern Europe cohort
  publication-title: J. Med. Virol.
  doi: 10.1002/jmv.29524
– ident: ref_92
  doi: 10.3389/fonc.2024.1356581
– volume: 13
  start-page: 1279
  year: 2014
  ident: ref_214
  article-title: The next generation of HPV vaccines: Nonavalent vaccine V503 on the horizon
  publication-title: Expert. Rev. Vaccines
  doi: 10.1586/14760584.2014.963561
SSID ssj0000913851
Score 2.289336
SecondaryResourceType review_article
Snippet Cervical cancer ranks third in mortality and fourth in incidence among women worldwide as one of the leading causes of death from cancer in females. The main...
SourceID doaj
pubmedcentral
proquest
gale
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage 1000
SubjectTerms Cancer
Carcinogenesis
Carcinogens
Cell cycle
Cellular biology
Cervical cancer
DNA methylation
early proteins
Enzymes
Epidemiology
Epigenetic inheritance
Epigenetics
exosomes
Gene expression
Genetic aspects
Genotypes
HPV
Human papillomavirus
Immunization
Immunotherapy
Infection
Infections
miRNA
Molecular modelling
Mortality
Papillomavirus infections
Pathogenesis
Phylogenetics
Public health
Review
Romania
Socioeconomic factors
Therapeutic applications
Tumor suppressor genes
Vaccination
Vaccines
Womens health
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQpUpcEJRXSqmMhMSl0caxYzvc2qXVFmmBA0W9RYkfYg91qs32wL9nxs6uNgKJC9fYjpKZ8cw31vgbQt7LjpcGKYZ8aetceCnzTraQpQhdOWGYtPG8Y_lFLm7E59vqdq_VF9aEJXrgJLhZzb0obGGthdCvhNMc1lujbMeYZ9yi9y3qYi-Zij64ZhywRLoSzCGvn91hfVvqlDTcDeC5KzzZnkSjSNr_p2vei03Tusm9QHT1lDwZESQ9T1_-jDxy4Ygcpp6Sv56TsNw2vKXXYcDUe6CrsOnp4tuP_NManRudRwcBL5mjztcf6ddg-sjYsArDGb3GOyOOAsjGo7Qz2gZLL--RthNvPNJlb7G-KB31vSA3V5ff54t8bKqQm6qsNjmrPIAubVvOS94ZUVthQL7etor52tlKwtNaSKdBe4X2IMaycNKU3CiI5Zy_JAehD-41ocx3SteW2U5gXz_dtZDfSOOV77RVLc_IbCvc5j5xZzSQc6A6mr-rIyMXqIPdbOS-jg9gZjNaRPMvi8jIB9RggzsU1GTa8aIBfDRyXTXnWpRKAlKWGTmZzISdZabDWxtoxp09NBxiPcAmVeiMvNsN40qsVguuf0hzIvISGXmVTGb3S5HNiCkQjp4Y0-SfpyNh9TPyfiMbHwfEd_w_pPSGPC6xlXEh8lKdkIPN-sG9BXy16U7jVvoN_NQlfA
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwELdgExISQjC-AgMZCYmXRY1jx3Z4QVvp1CF1TIihvUWJP0Qf5pSme-C_5y5OyyIQr7FbOb7vy93vCHknG54bhBjyuS1T4aVMG1lDlCJ04YRh0vb5jsW5nF-Kz1fF1ZBw64ayyq1O7BW1bQ3myCccdCyYK5Xpj6ufKU6Nwq-rwwiNu2QfljXw-f7J7Pzi6y7LgqiX4FPE1mAO8f3kGuvc4sSk7roDDV5ghntklXrw_r9V9C0bNa6fvGWQTh-Rh4MnSY8j6R-TOy4ckHtxtuSvA_IgJuRo7DN6QsJiOwiXnoUOQ_KOLsOmpfOL7-mnNSo9Ou0VB_zpFHlh_YF-CabtkRyWoTuiZ9hL4ig435hiO6J1sHS2QjhP7ISki9Zi3VFMAT4ll6ezb9N5OgxbSE2RF5uUFR6cMW1rznPeGFFaYTKbeVsr5ktnCwlPSyGdBqpm2sO15pmTJudGgY3n_BnZC21wLwhlvlG6tMw2Auf96aaGuEcar3yjrap5Qibby65WEVOjglgEyVP9mzwJOUGa7HYjJnb_AHZWg4hVJfcCTmytBSdRCac5cJo1yjaMecZtQt4jRSuUXCCbqYcGBDg0YmBVx1rkSoIHLRNyONoJEmfGy1ueqAaJ76o__JmQt7tl_CVWsQXX3sQ9vUcmEvI8stDulXqUI6bgcvSIuUbvPF4Jyx89Hjii9HHwBF_-_1yvyP0chxdnIs3VIdnbrG_ca_CoNs2bQWx-A5dHIts
  priority: 102
  providerName: ProQuest
Title Molecular Insights into HPV-Driven Cervical Cancer: Oncoproteins, Immune Evasion, and Epigenetic Modifications
URI https://www.ncbi.nlm.nih.gov/pubmed/40431173
https://www.proquest.com/docview/3212082708
https://www.proquest.com/docview/3212782224
https://pubmed.ncbi.nlm.nih.gov/PMC12113743
https://doaj.org/article/93f40d0ddd32474e8316ddc7db11f13d
Volume 13
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9RAEF9qi-CL-G1qPVYQfGlskt3sbgSR9rxyFa4W8aRvIdkPPLCb9nIF-987s8kdDRYffN2PsNmZnfnNsPsbQt6KmmUaKYZcZoqYOyHiWlQQpXCVW65TYUK-Y3YqpnP-5Tw_3yLrcqn9BrZ3hnZYT2q-_PX-99XNJzjwHzHihJD94AKvrnVFkNqLFoxyjknre2QHvJPAgGzWQ_5gnYuUAcroHgv_Y_rATwU6_7-N9i2vNbxRectFHT8iD3tsSQ87ZXhMtqx_Qu531SZvnhI_W5fCpSe-xaC8pQu_auj07Ef8eYlmj46D6YCPjFEblh_oV6-bwOWw8O0-PcHXJJYC_MYk2z6tvKGTSyT0xLeQdNYYvHnUJQGfkfnx5Pt4GvflFmKdZ_kqTnMHcEyZirGM1ZoXhuvEJM5UMnWFNbmA1oILq0CuiXKwjVlihc6YluDlGXtOtn3j7UtCU1dLVZjU1Bwr_qm6gshHaCddrYysWEQO1ptbXnasGiVEIyiO8m5xROQIZbAZjazYoQFGlv0hKwvmOKzYGAMwUXKrGOia0dLUaepSZiLyDiVYojaBmHTVP0GARSMLVnmoeCYFYGgRkb3BSDhzeti91oFyrbIlAxQAgEomKiJvNt04E--xedtcd2MCJuMRedGpzOaXAs9RKmFz1ECZBv887PGLn4ERHHn6GGDB3f-f-oo8yLC0ccLjTO6R7dXy2r4GvLWqR2TnaHJ69m0U8hWjcJz-AALrMc8
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELemTQgkhGB8BQYYCcTLoia24zhICG1dp5atZUIb2ltI7Fj0YU5pOqH9U_yN3OWjLALxtlfbiRzfpy93vyPkjcw50wgxZJlJfGGl9HOZwS1FqKgQOpSmjndMZ3J8Jj6dR-cb5FdXC4NplZ1OrBW1KTXGyAccdCyYqzhQHxc_fOwahX9XuxYaDVscFVc_4cpWfZgcAH3fMnY4Oh2O_bargK8jFq38MLLgdSiTcc54rkVihA5MYE0WhzYpTCRhNBGyULD9QFmuIhYUUjOuYzBmGAAFlb8lsKJ1k2ztj2YnX9ZRHUTZBB-mKUXmPAkGF5hX13Roqi4qsBgRRtR7VrBuFvC3SbhmE_v5mtcM4OF9cq_1XOlew2oPyEbhtsmtppfl1Ta52wQAaVPX9JC4add4l05chSGAis7dqqTjk6_-wRKVLB3WigpeOkTeW76nn50ua-SIuat26QRrVwoKzj6G9HZp5gwdLRA-FCsv6bQ0mOfUhBwfkbMbIcNjsulKVzwlNLR5rBITmlxgf0GVZ3DPktrGNlcmzrhHBt1hp4sGwyOFuw-SJ_03eTyyjzRZr0YM7noAVqatSKcJtwJ2bIwBpzQWheLA2UbHJg9DG3LjkXdI0RQ1BZBNZ23BA2waMbfSPSVYLMFjlx7Z6a0ECdf96Y4n0lbDVOkfefDI6_U0PolZc64oL5s1tQcoPPKkYaH1J9WoSmEMh6N6zNX75v6Mm3-v8ccRFZCD5_ns__t6RW6PT6fH6fFkdvSc3GHYODkQPot3yOZqeVm8AG9ulb9sRYiSbzcttb8BvwZfPA
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLamTiCkCcG4BQYYCcTLoiaxYztICG29qGW0VIihvYXEjrU-LClNJ7S_xq_jnFzKIhBve42dyPa5-uSc7xDyWqQs0AgxZAMTudwK4aYigVsKV2HGtS9MFe-YzcXklH88C892yK-2FgbTKludWClqU2iMkfcZ6FgwV9JTfdukRSyG4w-rHy52kMI_rW07jZpFTrKrn3B9K99Ph0DrN0EwHn0dTNymw4CrwyDcuH5owQNRJmEsYKnmkeHaM541ifRtlJlQwNOIi0zBVjxlmQoDLxM6YFqCYcNgKKj_XQlWkffI7vFovviyjfAg4ib4M3VZMmOR17_AHLu6W1N5UYL1CDG63rGIVeOAv83DNfvYzd28ZgzH98jdxoulRzXb3Sc7Wb5PbtV9La_2yV4dDKR1jdMDks_aJrx0mpcYDijpMt8UdLL45g7XqHDpoFJa8NEB8uH6Hf2c66JCkVjm5SGdYh1LRsHxx_DeIU1yQ0crhBLFKkw6KwzmPNXhx4fk9EbI8Ij08iLPnhDq21SqyPgm5dhrUKUJ3LmEttKmysiEOaTfHna8qvE8YrgHIXnif5PHIcdIk-1sxOOuHsDMuBHvOGKWw4qNMeCgSp4pBlxutDSp71ufGYe8RYrGqDWAbDppih9g0Yi_FR8pHkgB3rtwyEFnJki77g63PBE32qaM_8iGQ15th_FNzKDLs-KynlN5g9whj2sW2m6pQljyJRyO6jBXZ8_dkXx5XmGRI0IgAy_06f_X9ZLcBmmNP03nJ8_InQB7KHvcDeQB6W3Wl9lzcOw26YtGgij5ftNC-xvbkGNo
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Molecular+Insights+into+HPV-Driven+Cervical+Cancer%3A+Oncoproteins%2C+Immune+Evasion%2C+and+Epigenetic+Modifications&rft.jtitle=Microorganisms+%28Basel%29&rft.au=Pavelescu%2C+Luciana+Alexandra&rft.au=Mititelu-Zafiu%2C+Nicoleta+Larisa&rft.au=Mindru%2C+Dana+Elena&rft.au=Vladareanu%2C+Radu&rft.date=2025-04-27&rft.pub=MDPI&rft.eissn=2076-2607&rft.volume=13&rft.issue=5&rft_id=info:doi/10.3390%2Fmicroorganisms13051000&rft.externalDocID=PMC12113743
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2076-2607&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2076-2607&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2076-2607&client=summon