Folic acid modulates VPO1 DNA methylation levels and alleviates oxidative stress-induced apoptosis in vivo and in vitro

• Published in: Redox biology Vol. 19; pp. 81 - 91
• Main Authors: Cui, Shanshan, Lv, Xin, Li, Wen, Li, Zhenshu, Liu, Huan, Gao, Yuxia, Huang, Guowei
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2018; Elsevier
• Subjects: Animals; Antioxidants - pharmacology; Apoptosis; Apoptosis - drug effects; Atherosclerosis; DNA methylation; DNA Methylation - drug effects; Folic acid; Folic Acid - pharmacology; Human Umbilical Vein Endothelial Cells; Humans; Lipoproteins, LDL - blood; Lipoproteins, LDL - metabolism; Mice, Inbred C57BL; Oxidative stress; Oxidative Stress - drug effects; Peroxidases - genetics; Research Paper; Vascular peroxidase 1; Vitamin B Complex - pharmacology; Oxidative stress; HFD; MDA; MTS; Gpx; Folic acid; DNMT; LDH; FITC; VPO1; 5-mC; Atherosclerosis; DNA methylation; WT; 8-OHdG; MALDI-TOF; SOD; T-AOC; ox-LDL; CVD; AS; CAT; ROS; CpGs; SAH; Vascular peroxidase 1; HUVECs; PCR; SAM; Apoptosis

Endothelial cell injury and apoptosis play a primary role in the pathogenesis of atherosclerosis. Moreover, accumulating evidence indicates that oxidative injury is an important risk factor for endothelial cell damage. In addition, low folate levels are considered a contributing factor to promotion...