Bioinspired copper single‐atom nanozyme as a superoxide dismutase‐like antioxidant for sepsis treatment

• Published in: Exploration (Beijing, China) Vol. 2; no. 4; pp. 20210267 - n/a
• Main Authors: Yang, Ji, Zhang, Ruofei, Zhao, Hanqing, Qi, Haifeng, Li, Jingyun, Li, Jian‐Feng, Zhou, Xinyao, Wang, Aiqin, Fan, Kelong, Yan, Xiyun, Zhang, Tao
• Format: Journal Article
• Language: English
• Published: China John Wiley & Sons, Inc 01.08.2022; John Wiley and Sons Inc; Wiley
• Subjects: Animal models; Antioxidants; bioinspired; Carbon; Copper; Cytokines; Electrons; Enzymes; Free radicals; Immune system; Inflammation; Inflammatory response; Morbidity; Nitrogen; Oxidative stress; Physiology; Reactive nitrogen species; Reactive oxygen species; Sepsis; single‐atom nanozyme; Superoxide dismutase; Systemic inflammatory response syndrome; Transmission electron microscopy; Tumor necrosis factor-TNF; Wavelet transforms; single‐atom nanozyme; bioinspired; superoxide dismutase; sepsis; reactive oxygen species

Sepsis is a systemic inflammatory response syndrome with high morbidity and mortality mediated by infection‐caused oxidative stress. Early antioxidant intervention by removing excessively produced reactive oxygen and nitrogen species (RONS) is beneficial to the prevention and treatment of sepsis. Ho...