Bioinspired copper single‐atom nanozyme as a superoxide dismutase‐like antioxidant for sepsis treatment

Sepsis is a systemic inflammatory response syndrome with high morbidity and mortality mediated by infection‐caused oxidative stress. Early antioxidant intervention by removing excessively produced reactive oxygen and nitrogen species (RONS) is beneficial to the prevention and treatment of sepsis. Ho...

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Published inExploration (Beijing, China) Vol. 2; no. 4; pp. 20210267 - n/a
Main Authors Yang, Ji, Zhang, Ruofei, Zhao, Hanqing, Qi, Haifeng, Li, Jingyun, Li, Jian‐Feng, Zhou, Xinyao, Wang, Aiqin, Fan, Kelong, Yan, Xiyun, Zhang, Tao
Format Journal Article
LanguageEnglish
Published China John Wiley & Sons, Inc 01.08.2022
John Wiley and Sons Inc
Wiley
Subjects
Animal models
Antioxidants
bioinspired
Carbon
Copper
Cytokines
Electrons
Enzymes
Free radicals
Immune system
Inflammation
Inflammatory response
Morbidity
Nitrogen
Oxidative stress
Physiology
Reactive nitrogen species
Reactive oxygen species
Sepsis
single‐atom nanozyme
Superoxide dismutase
Systemic inflammatory response syndrome
Transmission electron microscopy
Tumor necrosis factor-TNF
Wavelet transforms
single‐atom nanozyme
bioinspired
superoxide dismutase
sepsis
reactive oxygen species
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Abstract Sepsis is a systemic inflammatory response syndrome with high morbidity and mortality mediated by infection‐caused oxidative stress. Early antioxidant intervention by removing excessively produced reactive oxygen and nitrogen species (RONS) is beneficial to the prevention and treatment of sepsis. However, traditional antioxidants have failed to improve patient outcomes due to insufficient activity and sustainability. Herein, by mimicking the electronic and structural characteristics of natural Cu‐only superoxide dismutase (SOD5), a single‐atom nanozyme (SAzyme) featuring coordinately unsaturated and atomically dispersed Cu‐N4 site was synthesized for effective sepsis treatment. The de novo‐designed Cu‐SAzyme exhibits a superior SOD‐like activity to efficiently eliminate O2•−, which is the source of multiple RONS, thus blocking the free radical chain reaction and subsequent inflammatory response in the early stage of sepsis. Moreover, the Cu‐SAzyme effectively harnessed systemic inflammation and multi‐organ injuries in sepsis animal models. These findings indicate that the developed Cu‐SAzyme possesses great potential as therapeutic nanomedicines for the treatment of sepsis. A SOD‐inspired copper single‐atom nanozyme (Cu‐SAzyme) was designed and synthesized by a two‐step scaffold‐adsorption method. The Cu‐SAzyme exhibits high catalytic activity to scavenge superoxide anion, the initiator of ROS, and thus effectively prevents the disease progression in septic animals.
AbstractList Abstract Sepsis is a systemic inflammatory response syndrome with high morbidity and mortality mediated by infection‐caused oxidative stress. Early antioxidant intervention by removing excessively produced reactive oxygen and nitrogen species (RONS) is beneficial to the prevention and treatment of sepsis. However, traditional antioxidants have failed to improve patient outcomes due to insufficient activity and sustainability. Herein, by mimicking the electronic and structural characteristics of natural Cu‐only superoxide dismutase (SOD5), a single‐atom nanozyme (SAzyme) featuring coordinately unsaturated and atomically dispersed Cu‐N4 site was synthesized for effective sepsis treatment. The de novo‐designed Cu‐SAzyme exhibits a superior SOD‐like activity to efficiently eliminate O2•−, which is the source of multiple RONS, thus blocking the free radical chain reaction and subsequent inflammatory response in the early stage of sepsis. Moreover, the Cu‐SAzyme effectively harnessed systemic inflammation and multi‐organ injuries in sepsis animal models. These findings indicate that the developed Cu‐SAzyme possesses great potential as therapeutic nanomedicines for the treatment of sepsis.
Sepsis is a systemic inflammatory response syndrome with high morbidity and mortality mediated by infection‐caused oxidative stress. Early antioxidant intervention by removing excessively produced reactive oxygen and nitrogen species (RONS) is beneficial to the prevention and treatment of sepsis. However, traditional antioxidants have failed to improve patient outcomes due to insufficient activity and sustainability. Herein, by mimicking the electronic and structural characteristics of natural Cu‐only superoxide dismutase (SOD5), a single‐atom nanozyme (SAzyme) featuring coordinately unsaturated and atomically dispersed Cu‐N4 site was synthesized for effective sepsis treatment. The de novo‐designed Cu‐SAzyme exhibits a superior SOD‐like activity to efficiently eliminate O2•−, which is the source of multiple RONS, thus blocking the free radical chain reaction and subsequent inflammatory response in the early stage of sepsis. Moreover, the Cu‐SAzyme effectively harnessed systemic inflammation and multi‐organ injuries in sepsis animal models. These findings indicate that the developed Cu‐SAzyme possesses great potential as therapeutic nanomedicines for the treatment of sepsis.
Sepsis is a systemic inflammatory response syndrome with high morbidity and mortality mediated by infection‐caused oxidative stress. Early antioxidant intervention by removing excessively produced reactive oxygen and nitrogen species (RONS) is beneficial to the prevention and treatment of sepsis. However, traditional antioxidants have failed to improve patient outcomes due to insufficient activity and sustainability. Herein, by mimicking the electronic and structural characteristics of natural Cu‐only superoxide dismutase (SOD5), a single‐atom nanozyme (SAzyme) featuring coordinately unsaturated and atomically dispersed Cu‐N4 site was synthesized for effective sepsis treatment. The de novo‐designed Cu‐SAzyme exhibits a superior SOD‐like activity to efficiently eliminate O2•−, which is the source of multiple RONS, thus blocking the free radical chain reaction and subsequent inflammatory response in the early stage of sepsis. Moreover, the Cu‐SAzyme effectively harnessed systemic inflammation and multi‐organ injuries in sepsis animal models. These findings indicate that the developed Cu‐SAzyme possesses great potential as therapeutic nanomedicines for the treatment of sepsis. A SOD‐inspired copper single‐atom nanozyme (Cu‐SAzyme) was designed and synthesized by a two‐step scaffold‐adsorption method. The Cu‐SAzyme exhibits high catalytic activity to scavenge superoxide anion, the initiator of ROS, and thus effectively prevents the disease progression in septic animals.
Sepsis is a systemic inflammatory response syndrome with high morbidity and mortality mediated by infection‐caused oxidative stress. Early antioxidant intervention by removing excessively produced reactive oxygen and nitrogen species (RONS) is beneficial to the prevention and treatment of sepsis. However, traditional antioxidants have failed to improve patient outcomes due to insufficient activity and sustainability. Herein, by mimicking the electronic and structural characteristics of natural Cu‐only superoxide dismutase (SOD5), a single‐atom nanozyme (SAzyme) featuring coordinately unsaturated and atomically dispersed Cu‐N 4 site was synthesized for effective sepsis treatment. The de novo‐designed Cu‐SAzyme exhibits a superior SOD‐like activity to efficiently eliminate O 2 •− , which is the source of multiple RONS, thus blocking the free radical chain reaction and subsequent inflammatory response in the early stage of sepsis. Moreover, the Cu‐SAzyme effectively harnessed systemic inflammation and multi‐organ injuries in sepsis animal models. These findings indicate that the developed Cu‐SAzyme possesses great potential as therapeutic nanomedicines for the treatment of sepsis. A SOD‐inspired copper single‐atom nanozyme (Cu‐SAzyme) was designed and synthesized by a two‐step scaffold‐adsorption method. The Cu‐SAzyme exhibits high catalytic activity to scavenge superoxide anion, the initiator of ROS, and thus effectively prevents the disease progression in septic animals.
Sepsis is a systemic inflammatory response syndrome with high morbidity and mortality mediated by infection‐caused oxidative stress. Early antioxidant intervention by removing excessively produced reactive oxygen and nitrogen species (RONS) is beneficial to the prevention and treatment of sepsis. However, traditional antioxidants have failed to improve patient outcomes due to insufficient activity and sustainability. Herein, by mimicking the electronic and structural characteristics of natural Cu‐only superoxide dismutase (SOD5), a single‐atom nanozyme (SAzyme) featuring coordinately unsaturated and atomically dispersed Cu‐N 4 site was synthesized for effective sepsis treatment. The de novo‐designed Cu‐SAzyme exhibits a superior SOD‐like activity to efficiently eliminate O 2 •− , which is the source of multiple RONS, thus blocking the free radical chain reaction and subsequent inflammatory response in the early stage of sepsis. Moreover, the Cu‐SAzyme effectively harnessed systemic inflammation and multi‐organ injuries in sepsis animal models. These findings indicate that the developed Cu‐SAzyme possesses great potential as therapeutic nanomedicines for the treatment of sepsis.
Sepsis is a systemic inflammatory response syndrome with high morbidity and mortality mediated by infection-caused oxidative stress. Early antioxidant intervention by removing excessively produced reactive oxygen and nitrogen species (RONS) is beneficial to the prevention and treatment of sepsis. However, traditional antioxidants have failed to improve patient outcomes due to insufficient activity and sustainability. Herein, by mimicking the electronic and structural characteristics of natural Cu-only superoxide dismutase (SOD5), a single-atom nanozyme (SAzyme) featuring coordinately unsaturated and atomically dispersed Cu-N site was synthesized for effective sepsis treatment. The de novo-designed Cu-SAzyme exhibits a superior SOD-like activity to efficiently eliminate O , which is the source of multiple RONS, thus blocking the free radical chain reaction and subsequent inflammatory response in the early stage of sepsis. Moreover, the Cu-SAzyme effectively harnessed systemic inflammation and multi-organ injuries in sepsis animal models. These findings indicate that the developed Cu-SAzyme possesses great potential as therapeutic nanomedicines for the treatment of sepsis.
Sepsis is a systemic inflammatory response syndrome with high morbidity and mortality mediated by infection-caused oxidative stress. Early antioxidant intervention by removing excessively produced reactive oxygen and nitrogen species (RONS) is beneficial to the prevention and treatment of sepsis. However, traditional antioxidants have failed to improve patient outcomes due to insufficient activity and sustainability. Herein, by mimicking the electronic and structural characteristics of natural Cu-only superoxide dismutase (SOD5), a single-atom nanozyme (SAzyme) featuring coordinately unsaturated and atomically dispersed Cu-N4 site was synthesized for effective sepsis treatment. The de novo-designed Cu-SAzyme exhibits a superior SOD-like activity to efficiently eliminate O2 •-, which is the source of multiple RONS, thus blocking the free radical chain reaction and subsequent inflammatory response in the early stage of sepsis. Moreover, the Cu-SAzyme effectively harnessed systemic inflammation and multi-organ injuries in sepsis animal models. These findings indicate that the developed Cu-SAzyme possesses great potential as therapeutic nanomedicines for the treatment of sepsis.Sepsis is a systemic inflammatory response syndrome with high morbidity and mortality mediated by infection-caused oxidative stress. Early antioxidant intervention by removing excessively produced reactive oxygen and nitrogen species (RONS) is beneficial to the prevention and treatment of sepsis. However, traditional antioxidants have failed to improve patient outcomes due to insufficient activity and sustainability. Herein, by mimicking the electronic and structural characteristics of natural Cu-only superoxide dismutase (SOD5), a single-atom nanozyme (SAzyme) featuring coordinately unsaturated and atomically dispersed Cu-N4 site was synthesized for effective sepsis treatment. The de novo-designed Cu-SAzyme exhibits a superior SOD-like activity to efficiently eliminate O2 •-, which is the source of multiple RONS, thus blocking the free radical chain reaction and subsequent inflammatory response in the early stage of sepsis. Moreover, the Cu-SAzyme effectively harnessed systemic inflammation and multi-organ injuries in sepsis animal models. These findings indicate that the developed Cu-SAzyme possesses great potential as therapeutic nanomedicines for the treatment of sepsis.
Author Fan, Kelong
Wang, Aiqin
Zhang, Ruofei
Yan, Xiyun
Zhao, Hanqing
Li, Jingyun
Li, Jian‐Feng
Yang, Ji
Qi, Haifeng
Zhou, Xinyao
Zhang, Tao
AuthorAffiliation 4 CAS Key Laboratory of Science and Technology on Applied Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian China
1 Collaborative Innovation Center of Chemistry for Energy Materials (iChEM), Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian China
7 Key Laboratory of Infection and Immunity Institute of Biophysics Chinese Academy of Sciences Beijing China
5 University of Chinese Academy of Sciences, Chinese Academy of Sciences Beijing China
8 School of Engineering and Applied Science University of Pennsylvania Philadelphia Pennsylvania USA
3 Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) College of Chemistry and Chemical Engineering Xiamen University Xiamen China
2 CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics Chinese Academy of Sciences Beijing China
6 Nanozyme Medical Center, School of Basic Medical Sciences Zhengzhou University Zhengzhou Ch
AuthorAffiliation_xml – name: 4 CAS Key Laboratory of Science and Technology on Applied Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian China
– name: 7 Key Laboratory of Infection and Immunity Institute of Biophysics Chinese Academy of Sciences Beijing China
– name: 8 School of Engineering and Applied Science University of Pennsylvania Philadelphia Pennsylvania USA
– name: 2 CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics Chinese Academy of Sciences Beijing China
– name: 3 Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) College of Chemistry and Chemical Engineering Xiamen University Xiamen China
– name: 5 University of Chinese Academy of Sciences, Chinese Academy of Sciences Beijing China
– name: 1 Collaborative Innovation Center of Chemistry for Energy Materials (iChEM), Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian China
– name: 6 Nanozyme Medical Center, School of Basic Medical Sciences Zhengzhou University Zhengzhou China
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  surname: Yang
  fullname: Yang, Ji
  organization: Chinese Academy of Sciences
– sequence: 2
  givenname: Ruofei
  surname: Zhang
  fullname: Zhang, Ruofei
  organization: Chinese Academy of Sciences
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  givenname: Hanqing
  surname: Zhao
  fullname: Zhao, Hanqing
  organization: University of Chinese Academy of Sciences, Chinese Academy of Sciences
– sequence: 4
  givenname: Haifeng
  surname: Qi
  fullname: Qi, Haifeng
  organization: Chinese Academy of Sciences
– sequence: 5
  givenname: Jingyun
  surname: Li
  fullname: Li, Jingyun
  organization: Chinese Academy of Sciences
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  givenname: Jian‐Feng
  surname: Li
  fullname: Li, Jian‐Feng
  organization: Xiamen University
– sequence: 7
  givenname: Xinyao
  surname: Zhou
  fullname: Zhou, Xinyao
  organization: University of Pennsylvania
– sequence: 8
  givenname: Aiqin
  orcidid: 0000-0003-4552-0360
  surname: Wang
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  email: aqwang@dicp.ac.cn
  organization: Chinese Academy of Sciences
– sequence: 9
  givenname: Kelong
  orcidid: 0000-0001-6285-1933
  surname: Fan
  fullname: Fan, Kelong
  email: fankelong@ibp.ac.cn
  organization: Zhengzhou University
– sequence: 10
  givenname: Xiyun
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  fullname: Yan, Xiyun
  email: yanxy@ibp.ac.cn
  organization: Zhengzhou University
– sequence: 11
  givenname: Tao
  surname: Zhang
  fullname: Zhang, Tao
  organization: Chinese Academy of Sciences
BackLink https://www.ncbi.nlm.nih.gov/pubmed/37325607$$D View this record in MEDLINE/PubMed
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Copyright 2022 The Authors. published by Henan University and John Wiley & Sons Australia, Ltd.
2022 The Authors. Exploration published by Henan University and John Wiley & Sons Australia, Ltd.
2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: 2022 The Authors. published by Henan University and John Wiley & Sons Australia, Ltd.
– notice: 2022 The Authors. Exploration published by Henan University and John Wiley & Sons Australia, Ltd.
– notice: 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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Issue 4
Keywords single‐atom nanozyme
bioinspired
superoxide dismutase
sepsis
reactive oxygen species
Language English
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2022 The Authors. Exploration published by Henan University and John Wiley & Sons Australia, Ltd.
This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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Snippet Sepsis is a systemic inflammatory response syndrome with high morbidity and mortality mediated by infection‐caused oxidative stress. Early antioxidant...
Sepsis is a systemic inflammatory response syndrome with high morbidity and mortality mediated by infection-caused oxidative stress. Early antioxidant...
Abstract Sepsis is a systemic inflammatory response syndrome with high morbidity and mortality mediated by infection‐caused oxidative stress. Early antioxidant...
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StartPage 20210267
SubjectTerms Animal models
Antioxidants
bioinspired
Carbon
Copper
Cytokines
Electrons
Enzymes
Free radicals
Immune system
Inflammation
Inflammatory response
Morbidity
Nitrogen
Oxidative stress
Physiology
Reactive nitrogen species
Reactive oxygen species
Sepsis
single‐atom nanozyme
Superoxide dismutase
Systemic inflammatory response syndrome
Transmission electron microscopy
Tumor necrosis factor-TNF
Wavelet transforms
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Title Bioinspired copper single‐atom nanozyme as a superoxide dismutase‐like antioxidant for sepsis treatment
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2FEXP.20210267
https://www.ncbi.nlm.nih.gov/pubmed/37325607
https://www.proquest.com/docview/3092807359
https://www.proquest.com/docview/2827253807
https://pubmed.ncbi.nlm.nih.gov/PMC10191017
https://doaj.org/article/8b258b8ea42243baac026b72f6475aa0
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