Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue

• Published in: Annals of neurology Vol. 78; no. 5; pp. 787 - 800
• Main Authors: Marquié, Marta, Normandin, Marc D., Vanderburg, Charles R., Costantino, Isabel M., Bien, Elizabeth A., Rycyna, Lisa G., Klunk, William E., Mathis, Chester A., Ikonomovic, Milos D., Debnath, Manik L., Vasdev, Neil, Dickerson, Bradford C., Gomperts, Stephen N., Growdon, John H., Johnson, Keith A., Frosch, Matthew P., Hyman, Bradley T., Gómez-Isla, Teresa
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.11.2015; Wiley Subscription Services, Inc
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - diagnostic imaging; Amyloid - metabolism; Autoradiography; Brain; Brain - diagnostic imaging; Cadaver; Carbolines; Dementia - diagnostic imaging; Female; Frontotemporal Lobar Degeneration - diagnostic imaging; Humans; Inclusion Bodies - diagnostic imaging; Intracranial Hemorrhages - diagnostic imaging; Male; Middle Aged; Pathology; Physiological psychology; Positron-Emission Tomography; Radiopharmaceuticals; tau Proteins - metabolism; Tauopathies - diagnostic imaging; TDP-43 Proteinopathies - diagnostic imaging

Objective To examine region‐ and substrate‐specific autoradiographic and in vitro binding patterns of positron emission tomography tracer [F‐18]‐AV‐1451 (previously known as T807), tailored to allow in vivo detection of paired helical filament‐tau–containing lesions, and to determine whether there i...