Mucociliary clearance: pathophysiological aspects
Summary Mucociliary clearance has long been known to be a significant innate defence mechanism against inhaled microbes and irritants. Important knowledge has been gathered regarding the anatomy and physiology of this system, and in recent years, extensive studies of the pathophysiology related to l...
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| Published in | Clinical physiology and functional imaging Vol. 34; no. 3; pp. 171 - 177 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
England
Blackwell Publishing Ltd
01.05.2014
Wiley Subscription Services, Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1475-0961 1475-097X 1475-097X |
| DOI | 10.1111/cpf.12085 |
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| Abstract | Summary
Mucociliary clearance has long been known to be a significant innate defence mechanism against inhaled microbes and irritants. Important knowledge has been gathered regarding the anatomy and physiology of this system, and in recent years, extensive studies of the pathophysiology related to lung diseases characterized by defective mucus clearance have resulted in a variety of therapies, which might be able to enhance clearance from the lungs. In addition, ways to study in vivo mucociliary clearance in humans have been developed. This can be used as a means to assess the effect of different pharmacological interventions on clearance rate, to study the importance of defective mucus clearance in different lung diseases or as a diagnostic tool in the work‐up of patients with recurrent airway diseases. The aim of this review is to provide an overview of the anatomy, physiology, pathophysiology, and clinical aspects of mucociliary clearance and to present a clinically applicable test that can be used for in vivo assessment of mucociliary clearance in patients. In addition, the reader will be presented with a protocol for this test, which has been validated and used as a diagnostic routine tool in the work‐up of patients suspected for primary ciliary dyskinesia at Rigshospitalet, Denmark for over a decade. |
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| AbstractList | Mucociliary clearance has long been known to be a significant innate defence mechanism against inhaled microbes and irritants. Important knowledge has been gathered regarding the anatomy and physiology of this system, and in recent years, extensive studies of the pathophysiology related to lung diseases characterized by defective mucus clearance have resulted in a variety of therapies, which might be able to enhance clearance from the lungs. In addition, ways to study
in vivo
mucociliary clearance in humans have been developed. This can be used as a means to assess the effect of different pharmacological interventions on clearance rate, to study the importance of defective mucus clearance in different lung diseases or as a diagnostic tool in the work‐up of patients with recurrent airway diseases. The aim of this review is to provide an overview of the anatomy, physiology, pathophysiology, and clinical aspects of mucociliary clearance and to present a clinically applicable test that can be used for
in vivo
assessment of mucociliary clearance in patients. In addition, the reader will be presented with a protocol for this test, which has been validated and used as a diagnostic routine tool in the work‐up of patients suspected for primary ciliary dyskinesia at
R
igshospitalet,
D
enmark for over a decade. Mucociliary clearance has long been known to be a significant innate defence mechanism against inhaled microbes and irritants. Important knowledge has been gathered regarding the anatomy and physiology of this system, and in recent years, extensive studies of the pathophysiology related to lung diseases characterized by defective mucus clearance have resulted in a variety of therapies, which might be able to enhance clearance from the lungs. In addition, ways to study in vivo mucociliary clearance in humans have been developed. This can be used as a means to assess the effect of different pharmacological interventions on clearance rate, to study the importance of defective mucus clearance in different lung diseases or as a diagnostic tool in the work-up of patients with recurrent airway diseases. The aim of this review is to provide an overview of the anatomy, physiology, pathophysiology, and clinical aspects of mucociliary clearance and to present a clinically applicable test that can be used for in vivo assessment of mucociliary clearance in patients. In addition, the reader will be presented with a protocol for this test, which has been validated and used as a diagnostic routine tool in the work-up of patients suspected for primary ciliary dyskinesia at Rigshospitalet, Denmark for over a decade. Summary Mucociliary clearance has long been known to be a significant innate defence mechanism against inhaled microbes and irritants. Important knowledge has been gathered regarding the anatomy and physiology of this system, and in recent years, extensive studies of the pathophysiology related to lung diseases characterized by defective mucus clearance have resulted in a variety of therapies, which might be able to enhance clearance from the lungs. In addition, ways to study in vivo mucociliary clearance in humans have been developed. This can be used as a means to assess the effect of different pharmacological interventions on clearance rate, to study the importance of defective mucus clearance in different lung diseases or as a diagnostic tool in the work-up of patients with recurrent airway diseases. The aim of this review is to provide an overview of the anatomy, physiology, pathophysiology, and clinical aspects of mucociliary clearance and to present a clinically applicable test that can be used for in vivo assessment of mucociliary clearance in patients. In addition, the reader will be presented with a protocol for this test, which has been validated and used as a diagnostic routine tool in the work-up of patients suspected for primary ciliary dyskinesia at Rigshospitalet, Denmark for over a decade. [PUBLICATION ABSTRACT] Mucociliary clearance has long been known to be a significant innate defence mechanism against inhaled microbes and irritants. Important knowledge has been gathered regarding the anatomy and physiology of this system, and in recent years, extensive studies of the pathophysiology related to lung diseases characterized by defective mucus clearance have resulted in a variety of therapies, which might be able to enhance clearance from the lungs. In addition, ways to study in vivo mucociliary clearance in humans have been developed. This can be used as a means to assess the effect of different pharmacological interventions on clearance rate, to study the importance of defective mucus clearance in different lung diseases or as a diagnostic tool in the work-up of patients with recurrent airway diseases. The aim of this review is to provide an overview of the anatomy, physiology, pathophysiology, and clinical aspects of mucociliary clearance and to present a clinically applicable test that can be used for in vivo assessment of mucociliary clearance in patients. In addition, the reader will be presented with a protocol for this test, which has been validated and used as a diagnostic routine tool in the work-up of patients suspected for primary ciliary dyskinesia at Rigshospitalet, Denmark for over a decade.Mucociliary clearance has long been known to be a significant innate defence mechanism against inhaled microbes and irritants. Important knowledge has been gathered regarding the anatomy and physiology of this system, and in recent years, extensive studies of the pathophysiology related to lung diseases characterized by defective mucus clearance have resulted in a variety of therapies, which might be able to enhance clearance from the lungs. In addition, ways to study in vivo mucociliary clearance in humans have been developed. This can be used as a means to assess the effect of different pharmacological interventions on clearance rate, to study the importance of defective mucus clearance in different lung diseases or as a diagnostic tool in the work-up of patients with recurrent airway diseases. The aim of this review is to provide an overview of the anatomy, physiology, pathophysiology, and clinical aspects of mucociliary clearance and to present a clinically applicable test that can be used for in vivo assessment of mucociliary clearance in patients. In addition, the reader will be presented with a protocol for this test, which has been validated and used as a diagnostic routine tool in the work-up of patients suspected for primary ciliary dyskinesia at Rigshospitalet, Denmark for over a decade. Summary Mucociliary clearance has long been known to be a significant innate defence mechanism against inhaled microbes and irritants. Important knowledge has been gathered regarding the anatomy and physiology of this system, and in recent years, extensive studies of the pathophysiology related to lung diseases characterized by defective mucus clearance have resulted in a variety of therapies, which might be able to enhance clearance from the lungs. In addition, ways to study in vivo mucociliary clearance in humans have been developed. This can be used as a means to assess the effect of different pharmacological interventions on clearance rate, to study the importance of defective mucus clearance in different lung diseases or as a diagnostic tool in the work‐up of patients with recurrent airway diseases. The aim of this review is to provide an overview of the anatomy, physiology, pathophysiology, and clinical aspects of mucociliary clearance and to present a clinically applicable test that can be used for in vivo assessment of mucociliary clearance in patients. In addition, the reader will be presented with a protocol for this test, which has been validated and used as a diagnostic routine tool in the work‐up of patients suspected for primary ciliary dyskinesia at Rigshospitalet, Denmark for over a decade. |
| Author | Mortensen, Jann Munkholm, Mathias |
| Author_xml | – sequence: 1 givenname: Mathias surname: Munkholm fullname: Munkholm, Mathias organization: Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark – sequence: 2 givenname: Jann surname: Mortensen fullname: Mortensen, Jann email: Jann Mortensen, Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen Ø, Denmark, jann.mortensen@regionh.dk organization: Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24119105$$D View this record in MEDLINE/PubMed |
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| Publisher | Blackwell Publishing Ltd Wiley Subscription Services, Inc |
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| References | Boucher RC. Cystic fibrosis: a disease of vulnerability to airway surface dehydration. Trends Mol Med (2007); 13: 231-240. Javidan-Nejad C, Bhalla S. Bronchiectasis. Radiol Clin North Am (2009); 47: 289-306. Bush A, Chodhari R, Collins N, Copeland F, Hall P, Harcourt J, Hariri M, Hogg C, Lucas J, Mitchison HM, O'Callaghan C, Phillips G. Primary ciliary dyskinesia: current state of the art. Arch Dis Child (2007); 92: 1136-1140. Bosse Y, Riesenfeld EP, Pare PD, Irvin CG. It's not all smooth muscle: non-smooth-muscle elements in control of resistance to airflow. Annu Rev Physiol (2010); 72: 437-462. Pryor JA. Physiotherapy for airway clearance in adults. Eur Respir J (1999); 14: 1418-1424. Hogg JC. Pathophysiology of airflow limitation in chronic obstructive pulmonary disease. Lancet (2004); 364: 709-721. Stenbit AE, Flume PA. Pulmonary exacerbations in cystic fibrosis. Curr Opin Pulm Med (2011); 17: 442-447. Meeks M, Bush A. Primary ciliary dyskinesia (PCD). Pediatr Pulmonol (2000); 29: 307-316. Miravitlles M, Marin A, Monso E, Vila S, de la Roza C, Hervas R, Esquinas C, Garcia M, Millares L, Morera J, Torres A. Colour of sputum is a marker for bacterial colonisation in chronic obstructive pulmonary disease. Respir Res (2010); 11: 58. Worlitzsch D, Tarran R, Ulrich M, Schwab U, Cekici A, Meyer KC, Birrer P, Bellon G, Berger J, Weiss T, Botzenhart K, Yankaskas JR, Randell S, Boucher RC, Doring G. Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients. J Clin Invest (2002); 109: 317-325. Amirav I, Cohen-Cymberknoh M, Shoseyov D, Kerem E. Primary ciliary dyskinesia: prospects for new therapies, building on the experience in cystic fibrosis. Paediatr Respir Rev (2009); 10: 58-62. Yoo Y, Koh YY. Current treatment for primary ciliary dyskinesia conditions. Expert Opin Pharmacother (2004); 5: 369-377. Calderon-Garciduenas L, Valencia-Salazar G, Rodriguez-Alcaraz A, Gambling TM, Garcia R, Osnaya N, Villarreal-Calderon A, Devlin RB, Carson JL. Ultrastructural nasal pathology in children chronically and sequentially exposed to air pollutants. Am J Respir Cell Mol Biol (2001); 24: 132-138. Bennett WD, Daviskas E, Hasani A, Mortensen J, Fleming J, Scheuch G. Mucociliary and cough clearance as a biomarker for therapeutic development. J Aerosol Med Pulm Drug Deliv (2010); 23: 261-272. Carson JL, Collier AM, Hu SC. Ultrastructural observations on cellular and subcellular aspects of experimental Mycoplasma pneumoniae disease. Infect Immun (1980); 29: 1117-1124. Mall MA. Role of cilia, mucus, and airway surface liquid in mucociliary dysfunction: lessons from mouse models. J Aerosol Med Pulm Drug Deliv (2008); 21: 13-24. Livraghi A, Randell SH. Cystic fibrosis and other respiratory diseases of impaired mucus clearance. Toxicol Pathol (2007); 35: 116-129. Mortensen J, Lange P, Nyboe J, Groth S. Lung mucociliary clearance. Eur J Nucl Med (1994); 21: 953-961. Wang LF, White DR, Andreoli SM, Mulligan RM, Discolo CM, Schlosser RJ. Cigarette smoke inhibits dynamic ciliary beat frequency in pediatric adenoid explants. Otolaryngol Head Neck Surg (2012); 146: 659-663. Chodhari R, Mitchison HM, Meeks M. Cilia, primary ciliary dyskinesia and molecular genetics. Paediatr Respir Rev (2004); 5: 69-76. Rubin BK. Mucus, phlegm, and sputum in cystic fibrosis. Respir Care (2009); 54: 726-732; discussion 732. Sagel SD, Davis SD, Campisi P, Dell SD. Update of respiratory tract disease in children with primary ciliary dyskinesia. Proc Am Thorac Soc (2011); 8: 438-443. Marthin JK, Mortensen J, Pressler T, Nielsen KG. Pulmonary radioaerosol mucociliary clearance in diagnosis of primary ciliary dyskinesia. Chest (2007); 132: 966-976. Afzelius BA. Cilia-related diseases. J Pathol (2004); 204: 470-477. Tarran R, Grubb BR, Gatzy JT, Davis CW, Boucher RC. The relative roles of passive surface forces and active ion transport in the modulation of airway surface liquid volume and composition. J Gen Physiol (2001); 118: 223-236. Randell SH, Boucher RC. Effective mucus clearance is essential for respiratory health. Am J Respir Cell Mol Biol (2006); 35: 20-28. Kondo M, Tamaoki J, Takeyama K, Isono K, Kawatani K, Izumo T, Nagai A. Elimination of IL-13 reverses established goblet cell metaplasia into ciliated epithelia in airway epithelial cell culture. Allergol Int (2006); 55: 329-336. Goeminne P, Dupont L. Non-cystic fibrosis bronchiectasis: diagnosis and management in 21st century. Postgrad Med J (2010); 86: 493-501. Mortensen J, Groth S, Lange P, Hermansen F. Effect of terbutaline on mucociliary clearance in asthmatic and healthy subjects after inhalation from a pressurised inhaler and a dry powder inhaler. Thorax (1991b); 46: 817-823. King PT. The pathophysiology of bronchiectasis. Int J Chron Obstruct Pulmon Dis (2009); 4: 411-419. Lommatzsch M. Airway hyperresponsiveness: new insights into the pathogenesis. Semin Respir Crit Care Med (2012); 33: 579-587. Soler-Cataluna JJ, Martinez-Garcia MA, Roman Sanchez P, Salcedo E, Navarro M, Ochando R. Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease. Thorax (2005); 60: 925-931. Robinson M, Eberl S, Tomlinson C, Daviskas E, Regnis JA, Bailey DL, Torzillo PJ, Menache M, Bye PT. Regional mucociliary clearance in patients with cystic fibrosis. J Aerosol Med (2000); 13: 73-86. Rogers DF. Mucociliary dysfunction in COPD: effect of current pharmacotherapeutic options. Pulm Pharmacol Ther (2005); 18: 1-8. Escudier E, Duquesnoy P, Papon JF, Amselem S. Ciliary defects and genetics of primary ciliary dyskinesia. Paediatr Respir Rev (2009); 10: 51-54. Lester MK, Flume PA. Airway-clearance therapy guidelines and implementation. Respir Care (2009); 54: 733-750; discussion 751-733. Fahy JV, Dickey BF. Airway mucus function and dysfunction. N Engl J Med (2010); 363: 2233-2247. Ilowite J, Spiegler P, Chawla S. Bronchiectasis: new findings in the pathogenesis and treatment of this disease. Curr Opin Infect Dis (2008); 21: 163-167. Reimer A, Klementsson K, Ursing J, Wretlind B. The mucociliary activity of the respiratory tract. I. Inhibitory effects of products of Pseudomonas aeruginosa on rabbit trachea in vitro. Acta Otolaryngol (1980); 90: 462-469. Marthin JK, Petersen N, Skovgaard LT, Nielsen KG. Lung function in patients with primary ciliary dyskinesia: a cross-sectional and 3-decade longitudinal study. Am J Respir Crit Care Med (2010); 181: 1262-1268. Button B, Cai LH, Ehre C, Kesimer M, Hill DB, Sheehan JK, Boucher RC, Rubinstein M. A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia. Science (2012); 337: 937-941. Wanner A, Salathe M, O'Riordan TG. Mucociliary clearance in the airways. Am J Respir Crit Care Med (1996); 154: 1868-1902. Bilton D. Update on non-cystic fibrosis bronchiectasis. Curr Opin Pulm Med (2008); 14: 595-599. Bennett WD. Effect of beta-adrenergic agonists on mucociliary clearance. J Allergy Clin Immunol (2002); 110: S291-S297. Mortensen J, Falk M, Groth S, Jensen C. The effects of postural drainage and positive expiratory pressure physiotherapy on tracheobronchial clearance in cystic fibrosis. Chest (1991a); 100: 1350-1357. Rautiainen M, Nuutinen J, Kiukaanniemi H, Collan Y. Ultrastructural changes in human nasal cilia caused by the common cold and recovery of ciliated epithelium. Ann Otol Rhinol Laryngol (1992); 101: 982-987. Evans SE, Xu Y, Tuvim MJ, Dickey BF. Inducible innate resistance of lung epithelium to infection. Annu Rev Physiol (2010); 72: 413-435. Knowles MR, Boucher RC. Mucus clearance as a primary innate defense mechanism for mammalian airways. J Clin Invest (2002); 109: 571-577. Porter ME, Johnson KA. Dynein structure and function. Annu Rev Cell Biol (1989); 5: 119-151. 2004; 364 2010; 11 2009; 47 1989; 5 2004; 204 2000; 29 1980; 29 2012; 146 2002; 110 2006; 35 2006; 55 1992; 101 2008; 14 2010; 363 2007; 92 2004; 5 2010; 181 2005; 60 1980; 90 2011; 17 2001; 24 2012; 33 2007; 13 2007; 35 2011; 8 1994; 21 1991a; 100 2010; 23 2010; 86 2009; 10 2009; 54 2000; 13 2007; 132 1999; 14 2008; 21 1991b; 46 1996; 154 2009; 4 2002; 109 2001; 118 2012; 337 2005; 18 2010; 72 e_1_2_8_28_1 e_1_2_8_24_1 e_1_2_8_47_1 e_1_2_8_26_1 e_1_2_8_49_1 e_1_2_8_3_1 e_1_2_8_5_1 e_1_2_8_7_1 e_1_2_8_9_1 e_1_2_8_20_1 e_1_2_8_43_1 e_1_2_8_22_1 e_1_2_8_41_1 e_1_2_8_17_1 e_1_2_8_19_1 e_1_2_8_13_1 e_1_2_8_36_1 Carson JL (e_1_2_8_12_1) 1980; 29 e_1_2_8_15_1 e_1_2_8_38_1 e_1_2_8_32_1 e_1_2_8_11_1 e_1_2_8_34_1 e_1_2_8_30_1 e_1_2_8_29_1 e_1_2_8_25_1 e_1_2_8_46_1 e_1_2_8_27_1 e_1_2_8_48_1 Stenbit AE (e_1_2_8_45_1) 2011; 17 e_1_2_8_2_1 e_1_2_8_4_1 e_1_2_8_6_1 e_1_2_8_8_1 e_1_2_8_21_1 e_1_2_8_42_1 e_1_2_8_23_1 e_1_2_8_44_1 e_1_2_8_40_1 e_1_2_8_18_1 e_1_2_8_39_1 e_1_2_8_14_1 e_1_2_8_35_1 e_1_2_8_16_1 e_1_2_8_37_1 e_1_2_8_10_1 e_1_2_8_31_1 e_1_2_8_33_1 e_1_2_8_50_1 |
| References_xml | – reference: Bennett WD. Effect of beta-adrenergic agonists on mucociliary clearance. J Allergy Clin Immunol (2002); 110: S291-S297. – reference: Wang LF, White DR, Andreoli SM, Mulligan RM, Discolo CM, Schlosser RJ. Cigarette smoke inhibits dynamic ciliary beat frequency in pediatric adenoid explants. Otolaryngol Head Neck Surg (2012); 146: 659-663. – reference: Wanner A, Salathe M, O'Riordan TG. Mucociliary clearance in the airways. Am J Respir Crit Care Med (1996); 154: 1868-1902. – reference: Bush A, Chodhari R, Collins N, Copeland F, Hall P, Harcourt J, Hariri M, Hogg C, Lucas J, Mitchison HM, O'Callaghan C, Phillips G. Primary ciliary dyskinesia: current state of the art. Arch Dis Child (2007); 92: 1136-1140. – reference: Hogg JC. Pathophysiology of airflow limitation in chronic obstructive pulmonary disease. Lancet (2004); 364: 709-721. – reference: Evans SE, Xu Y, Tuvim MJ, Dickey BF. Inducible innate resistance of lung epithelium to infection. Annu Rev Physiol (2010); 72: 413-435. – reference: Meeks M, Bush A. Primary ciliary dyskinesia (PCD). Pediatr Pulmonol (2000); 29: 307-316. – reference: Miravitlles M, Marin A, Monso E, Vila S, de la Roza C, Hervas R, Esquinas C, Garcia M, Millares L, Morera J, Torres A. Colour of sputum is a marker for bacterial colonisation in chronic obstructive pulmonary disease. Respir Res (2010); 11: 58. – reference: Boucher RC. Cystic fibrosis: a disease of vulnerability to airway surface dehydration. Trends Mol Med (2007); 13: 231-240. – reference: Marthin JK, Mortensen J, Pressler T, Nielsen KG. Pulmonary radioaerosol mucociliary clearance in diagnosis of primary ciliary dyskinesia. Chest (2007); 132: 966-976. – reference: Kondo M, Tamaoki J, Takeyama K, Isono K, Kawatani K, Izumo T, Nagai A. Elimination of IL-13 reverses established goblet cell metaplasia into ciliated epithelia in airway epithelial cell culture. Allergol Int (2006); 55: 329-336. – reference: Rogers DF. Mucociliary dysfunction in COPD: effect of current pharmacotherapeutic options. Pulm Pharmacol Ther (2005); 18: 1-8. – reference: Bennett WD, Daviskas E, Hasani A, Mortensen J, Fleming J, Scheuch G. Mucociliary and cough clearance as a biomarker for therapeutic development. J Aerosol Med Pulm Drug Deliv (2010); 23: 261-272. – reference: Sagel SD, Davis SD, Campisi P, Dell SD. Update of respiratory tract disease in children with primary ciliary dyskinesia. Proc Am Thorac Soc (2011); 8: 438-443. – reference: Amirav I, Cohen-Cymberknoh M, Shoseyov D, Kerem E. Primary ciliary dyskinesia: prospects for new therapies, building on the experience in cystic fibrosis. Paediatr Respir Rev (2009); 10: 58-62. – reference: Porter ME, Johnson KA. Dynein structure and function. Annu Rev Cell Biol (1989); 5: 119-151. – reference: Mortensen J, Lange P, Nyboe J, Groth S. Lung mucociliary clearance. Eur J Nucl Med (1994); 21: 953-961. – reference: Pryor JA. Physiotherapy for airway clearance in adults. Eur Respir J (1999); 14: 1418-1424. – reference: Ilowite J, Spiegler P, Chawla S. Bronchiectasis: new findings in the pathogenesis and treatment of this disease. Curr Opin Infect Dis (2008); 21: 163-167. – reference: Goeminne P, Dupont L. Non-cystic fibrosis bronchiectasis: diagnosis and management in 21st century. Postgrad Med J (2010); 86: 493-501. – reference: Worlitzsch D, Tarran R, Ulrich M, Schwab U, Cekici A, Meyer KC, Birrer P, Bellon G, Berger J, Weiss T, Botzenhart K, Yankaskas JR, Randell S, Boucher RC, Doring G. Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients. J Clin Invest (2002); 109: 317-325. – reference: Stenbit AE, Flume PA. Pulmonary exacerbations in cystic fibrosis. Curr Opin Pulm Med (2011); 17: 442-447. – reference: Tarran R, Grubb BR, Gatzy JT, Davis CW, Boucher RC. The relative roles of passive surface forces and active ion transport in the modulation of airway surface liquid volume and composition. J Gen Physiol (2001); 118: 223-236. – reference: Bosse Y, Riesenfeld EP, Pare PD, Irvin CG. It's not all smooth muscle: non-smooth-muscle elements in control of resistance to airflow. Annu Rev Physiol (2010); 72: 437-462. – reference: Soler-Cataluna JJ, Martinez-Garcia MA, Roman Sanchez P, Salcedo E, Navarro M, Ochando R. Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease. Thorax (2005); 60: 925-931. – reference: Javidan-Nejad C, Bhalla S. Bronchiectasis. Radiol Clin North Am (2009); 47: 289-306. – reference: Randell SH, Boucher RC. Effective mucus clearance is essential for respiratory health. Am J Respir Cell Mol Biol (2006); 35: 20-28. – reference: King PT. The pathophysiology of bronchiectasis. Int J Chron Obstruct Pulmon Dis (2009); 4: 411-419. – reference: Button B, Cai LH, Ehre C, Kesimer M, Hill DB, Sheehan JK, Boucher RC, Rubinstein M. A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia. Science (2012); 337: 937-941. – reference: Yoo Y, Koh YY. Current treatment for primary ciliary dyskinesia conditions. Expert Opin Pharmacother (2004); 5: 369-377. – reference: Livraghi A, Randell SH. Cystic fibrosis and other respiratory diseases of impaired mucus clearance. Toxicol Pathol (2007); 35: 116-129. – reference: Robinson M, Eberl S, Tomlinson C, Daviskas E, Regnis JA, Bailey DL, Torzillo PJ, Menache M, Bye PT. Regional mucociliary clearance in patients with cystic fibrosis. J Aerosol Med (2000); 13: 73-86. – reference: Rubin BK. Mucus, phlegm, and sputum in cystic fibrosis. Respir Care (2009); 54: 726-732; discussion 732. – reference: Bilton D. Update on non-cystic fibrosis bronchiectasis. Curr Opin Pulm Med (2008); 14: 595-599. – reference: Mortensen J, Groth S, Lange P, Hermansen F. Effect of terbutaline on mucociliary clearance in asthmatic and healthy subjects after inhalation from a pressurised inhaler and a dry powder inhaler. Thorax (1991b); 46: 817-823. – reference: Chodhari R, Mitchison HM, Meeks M. Cilia, primary ciliary dyskinesia and molecular genetics. Paediatr Respir Rev (2004); 5: 69-76. – reference: Lommatzsch M. Airway hyperresponsiveness: new insights into the pathogenesis. Semin Respir Crit Care Med (2012); 33: 579-587. – reference: Mortensen J, Falk M, Groth S, Jensen C. The effects of postural drainage and positive expiratory pressure physiotherapy on tracheobronchial clearance in cystic fibrosis. Chest (1991a); 100: 1350-1357. – reference: Reimer A, Klementsson K, Ursing J, Wretlind B. The mucociliary activity of the respiratory tract. I. Inhibitory effects of products of Pseudomonas aeruginosa on rabbit trachea in vitro. Acta Otolaryngol (1980); 90: 462-469. – reference: Escudier E, Duquesnoy P, Papon JF, Amselem S. Ciliary defects and genetics of primary ciliary dyskinesia. Paediatr Respir Rev (2009); 10: 51-54. – reference: Marthin JK, Petersen N, Skovgaard LT, Nielsen KG. Lung function in patients with primary ciliary dyskinesia: a cross-sectional and 3-decade longitudinal study. Am J Respir Crit Care Med (2010); 181: 1262-1268. – reference: Carson JL, Collier AM, Hu SC. Ultrastructural observations on cellular and subcellular aspects of experimental Mycoplasma pneumoniae disease. Infect Immun (1980); 29: 1117-1124. – reference: Calderon-Garciduenas L, Valencia-Salazar G, Rodriguez-Alcaraz A, Gambling TM, Garcia R, Osnaya N, Villarreal-Calderon A, Devlin RB, Carson JL. Ultrastructural nasal pathology in children chronically and sequentially exposed to air pollutants. Am J Respir Cell Mol Biol (2001); 24: 132-138. – reference: Mall MA. Role of cilia, mucus, and airway surface liquid in mucociliary dysfunction: lessons from mouse models. J Aerosol Med Pulm Drug Deliv (2008); 21: 13-24. – reference: Rautiainen M, Nuutinen J, Kiukaanniemi H, Collan Y. Ultrastructural changes in human nasal cilia caused by the common cold and recovery of ciliated epithelium. Ann Otol Rhinol Laryngol (1992); 101: 982-987. – reference: Fahy JV, Dickey BF. Airway mucus function and dysfunction. N Engl J Med (2010); 363: 2233-2247. – reference: Lester MK, Flume PA. Airway-clearance therapy guidelines and implementation. Respir Care (2009); 54: 733-750; discussion 751-733. – reference: Afzelius BA. Cilia-related diseases. J Pathol (2004); 204: 470-477. – reference: Knowles MR, Boucher RC. Mucus clearance as a primary innate defense mechanism for mammalian airways. J Clin Invest (2002); 109: 571-577. – volume: 154 start-page: 1868 year: 1996 end-page: 1902 article-title: Mucociliary clearance in the airways publication-title: Am J Respir Crit Care Med – volume: 21 start-page: 163 year: 2008 end-page: 167 article-title: Bronchiectasis: new findings in the pathogenesis and treatment of this disease publication-title: Curr Opin Infect Dis – volume: 110 start-page: S291 year: 2002 end-page: S297 article-title: Effect of beta‐adrenergic agonists on mucociliary clearance publication-title: J Allergy Clin Immunol – volume: 101 start-page: 982 year: 1992 end-page: 987 article-title: Ultrastructural changes in human nasal cilia caused by the common cold and recovery of ciliated epithelium publication-title: Ann Otol Rhinol Laryngol – volume: 5 start-page: 119 year: 1989 end-page: 151 article-title: Dynein structure and function publication-title: Annu Rev Cell Biol – volume: 13 start-page: 73 year: 2000 end-page: 86 article-title: Regional mucociliary clearance in patients with cystic fibrosis publication-title: J Aerosol Med – volume: 72 start-page: 437 year: 2010 end-page: 462 article-title: It's not all smooth muscle: non‐smooth‐muscle elements in control of resistance to airflow publication-title: Annu Rev Physiol – volume: 35 start-page: 116 year: 2007 end-page: 129 article-title: Cystic fibrosis and other respiratory diseases of impaired mucus clearance publication-title: Toxicol Pathol – volume: 29 start-page: 307 year: 2000 end-page: 316 article-title: Primary ciliary dyskinesia (PCD) publication-title: Pediatr Pulmonol – volume: 29 start-page: 1117 year: 1980 end-page: 1124 article-title: Ultrastructural observations on cellular and subcellular aspects of experimental Mycoplasma pneumoniae disease publication-title: Infect Immun – volume: 47 start-page: 289 year: 2009 end-page: 306 article-title: Bronchiectasis publication-title: Radiol Clin North Am – volume: 363 start-page: 2233 year: 2010 end-page: 2247 article-title: Airway mucus function and dysfunction publication-title: N Engl J Med – volume: 132 start-page: 966 year: 2007 end-page: 976 article-title: Pulmonary radioaerosol mucociliary clearance in diagnosis of primary ciliary dyskinesia publication-title: Chest – volume: 10 start-page: 51 year: 2009 end-page: 54 article-title: Ciliary defects and genetics of primary ciliary dyskinesia publication-title: Paediatr Respir Rev – volume: 109 start-page: 571 year: 2002 end-page: 577 article-title: Mucus clearance as a primary innate defense mechanism for mammalian airways publication-title: J Clin Invest – volume: 46 start-page: 817 year: 1991b end-page: 823 article-title: Effect of terbutaline on mucociliary clearance in asthmatic and healthy subjects after inhalation from a pressurised inhaler and a dry powder inhaler publication-title: Thorax – volume: 23 start-page: 261 year: 2010 end-page: 272 article-title: Mucociliary and cough clearance as a biomarker for therapeutic development publication-title: J Aerosol Med Pulm Drug Deliv – volume: 54 start-page: 733 year: 2009 end-page: 750 article-title: Airway‐clearance therapy guidelines and implementation publication-title: Respir Care – volume: 60 start-page: 925 year: 2005 end-page: 931 article-title: Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease publication-title: Thorax – volume: 5 start-page: 69 year: 2004 end-page: 76 article-title: Cilia, primary ciliary dyskinesia and molecular genetics publication-title: Paediatr Respir Rev – volume: 364 start-page: 709 year: 2004 end-page: 721 article-title: Pathophysiology of airflow limitation in chronic obstructive pulmonary disease publication-title: Lancet – volume: 90 start-page: 462 year: 1980 end-page: 469 article-title: The mucociliary activity of the respiratory tract. I. Inhibitory effects of products of Pseudomonas aeruginosa on rabbit trachea in vitro publication-title: Acta Otolaryngol – volume: 21 start-page: 953 year: 1994 end-page: 961 article-title: Lung mucociliary clearance publication-title: Eur J Nucl Med – volume: 54 start-page: 726 year: 2009 end-page: 732 article-title: Mucus, phlegm, and sputum in cystic fibrosis publication-title: Respir Care – volume: 118 start-page: 223 year: 2001 end-page: 236 article-title: The relative roles of passive surface forces and active ion transport in the modulation of airway surface liquid volume and composition publication-title: J Gen Physiol – volume: 14 start-page: 1418 year: 1999 end-page: 1424 article-title: Physiotherapy for airway clearance in adults publication-title: Eur Respir J – volume: 204 start-page: 470 year: 2004 end-page: 477 article-title: Cilia‐related diseases publication-title: J Pathol – volume: 11 start-page: 58 year: 2010 article-title: Colour of sputum is a marker for bacterial colonisation in chronic obstructive pulmonary disease publication-title: Respir Res – volume: 18 start-page: 1 year: 2005 end-page: 8 article-title: Mucociliary dysfunction in COPD: effect of current pharmacotherapeutic options publication-title: Pulm Pharmacol Ther – volume: 337 start-page: 937 year: 2012 end-page: 941 article-title: A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia publication-title: Science – volume: 21 start-page: 13 year: 2008 end-page: 24 article-title: Role of cilia, mucus, and airway surface liquid in mucociliary dysfunction: lessons from mouse models publication-title: J Aerosol Med Pulm Drug Deliv – volume: 86 start-page: 493 year: 2010 end-page: 501 article-title: Non‐cystic fibrosis bronchiectasis: diagnosis and management in 21st century publication-title: Postgrad Med J – volume: 24 start-page: 132 year: 2001 end-page: 138 article-title: Ultrastructural nasal pathology in children chronically and sequentially exposed to air pollutants publication-title: Am J Respir Cell Mol Biol – volume: 100 start-page: 1350 year: 1991a end-page: 1357 article-title: The effects of postural drainage and positive expiratory pressure physiotherapy on tracheobronchial clearance in cystic fibrosis publication-title: Chest – volume: 10 start-page: 58 year: 2009 end-page: 62 article-title: Primary ciliary dyskinesia: prospects for new therapies, building on the experience in cystic fibrosis publication-title: Paediatr Respir Rev – volume: 72 start-page: 413 year: 2010 end-page: 435 article-title: Inducible innate resistance of lung epithelium to infection publication-title: Annu Rev Physiol – volume: 146 start-page: 659 year: 2012 end-page: 663 article-title: Cigarette smoke inhibits dynamic ciliary beat frequency in pediatric adenoid explants publication-title: Otolaryngol Head Neck Surg – volume: 5 start-page: 369 year: 2004 end-page: 377 article-title: Current treatment for primary ciliary dyskinesia 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Mucociliary clearance has long been known to be a significant innate defence mechanism against inhaled microbes and irritants. Important knowledge has... Mucociliary clearance has long been known to be a significant innate defence mechanism against inhaled microbes and irritants. Important knowledge has been... Summary Mucociliary clearance has long been known to be a significant innate defence mechanism against inhaled microbes and irritants. Important knowledge has... |
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| SubjectTerms | Anatomy & physiology Animals Clearances cough clearance Cystic fibrosis diagnostic test Diseases Humans Lung - drug effects Lung - pathology Lung - physiopathology Lung diseases Lung Diseases - diagnosis Lung Diseases - physiopathology Lung Diseases - therapy Lungs mucociliary clearance Mucociliary Clearance - drug effects Mucus overview Patients Physiology Respiratory System Agents - therapeutic use Surgical implants Treatment Outcome |
| Title | Mucociliary clearance: pathophysiological aspects |
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