Low cerebrospinal fluid concentration of mitochondrial DNA in preclinical Alzheimer disease

• Published in: Annals of neurology Vol. 74; no. 5; pp. 655 - 668
• Main Authors: Podlesniy, Petar, Figueiro-Silva, Joana, Llado, Albert, Antonell, Anna, Sanchez-Valle, Raquel, Alcolea, Daniel, Lleo, Alberto, Molinuevo, Jose Luis, Serra, Nuria, Trullas, Ramon
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.11.2013; Wiley Subscription Services, Inc
• Subjects: Alzheimer Disease - cerebrospinal fluid; Alzheimer Disease - genetics; Amyloid beta-Protein Precursor - cerebrospinal fluid; Animals; Biomarkers - cerebrospinal fluid; Cognitive Dysfunction - cerebrospinal fluid; Cognitive Dysfunction - genetics; Deoxyribonucleic acid; DNA; DNA, Mitochondrial - cerebrospinal fluid; Female; Humans; Male; Medical research; Mice; Mice, Transgenic; Mitochondrial DNA; Peptide Fragments - cerebrospinal fluid; Phosphorylation; Presenilin-1 - genetics; Prodromal Symptoms; tau Proteins - cerebrospinal fluid; Transgenic animals

Objective To identify a novel biochemical marker that precedes clinical symptoms in Alzheimer disease (AD). Methods Using quantitative polymerase chain reaction techniques, we measured circulating cell‐free mitochondrial DNA (mtDNA) in cerebrospinal fluid (CSF) from study participants, selected from...