Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen
The response of animals to hypoxia is mediated by the hypoxia-inducible transcription factor. Human hypoxia-inducible factor is regulated by four Fe(II)- and 2-oxoglutarate-dependent oxygenases: prolyl hydroxylase domain enzymes 1-3 catalyse hydroxylation of two prolyl-residues in hypoxia-inducible...
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Published in | The FEBS journal Vol. 277; no. 19; pp. 4089 - 4099 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Oxford, UK : Blackwell Publishing Ltd
01.10.2010
Blackwell Publishing Ltd |
Subjects | |
Online Access | Get full text |
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