Hepatitis C virus infection causes hypolipidemia regardless of hepatic damage or nutritional state: An epidemiological survey of a large Japanese cohort
Aim: Infection with hepatitis C virus (HCV) is the leading cause of liver cirrhosis that develops into hepatocellular carcinoma. Previous studies have shown in vitro that lipids within hepatocytes are crucially important for a series of HCV infection–proliferation–release processes. On the other ha...
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Published in | Hepatology research Vol. 41; no. 6; pp. 530 - 541 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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Melbourne, Australia
Blackwell Publishing Asia
01.06.2011
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Abstract | Aim: Infection with hepatitis C virus (HCV) is the leading cause of liver cirrhosis that develops into hepatocellular carcinoma. Previous studies have shown in vitro that lipids within hepatocytes are crucially important for a series of HCV infection–proliferation–release processes. On the other hand, in the patients with HCV, the serum total cholesterol (Total‐C) and low‐density lipoprotein cholesterol (LDL‐C) levels have been reported to be lower. We conducted an epidemiological survey of a large cohort and investigated whether the lower serum lipid levels were caused by a direct or the secondary effects of HCV infection (i.e. hepatic damage or nutritional disorder).
Methods: Among 146 857 participants (male, 34%; female, 66%) undergoing public health examinations between 2002 and 2007 in Ibaraki Prefecture, Japan, the HCV positive rates determined by HCV antibody/antigen and/or RNA tests were 1.37% and 0.67% in males and females, respectively.
Results: In addition to Total‐C and LDL‐C, serum high‐density lipoprotein cholesterol and triglyceride concentrations were also significantly lower in the HCV positive subjects compared with the negative subjects, regardless of sex, age or nutritional state evaluated by body mass index. Multivariate analysis showed that HCV infection was the strongest among the factors to be significantly associated with the lower level of these lipids. Particularly, the hypolipidemia was also confirmed in the HCV positive subjects with normal aminotransferase levels (alanine aminotransferase ≤30 and aspartate aminotransferase ≤30).
Conclusion: This epidemiological survey in a large Japanese cohort suggests that the HCV infection itself might directly cause hypolipidemia, irrespective of host factors including age, hepatic damage and nutritional state. |
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AbstractList | Aim: Infection with hepatitis C virus (HCV) is the leading cause of liver cirrhosis that develops into hepatocellular carcinoma. Previous studies have shown in vitro that lipids within hepatocytes are crucially important for a series of HCV infection–proliferation–release processes. On the other hand, in the patients with HCV, the serum total cholesterol (Total‐C) and low‐density lipoprotein cholesterol (LDL‐C) levels have been reported to be lower. We conducted an epidemiological survey of a large cohort and investigated whether the lower serum lipid levels were caused by a direct or the secondary effects of HCV infection (i.e. hepatic damage or nutritional disorder).
Methods: Among 146 857 participants (male, 34%; female, 66%) undergoing public health examinations between 2002 and 2007 in Ibaraki Prefecture, Japan, the HCV positive rates determined by HCV antibody/antigen and/or RNA tests were 1.37% and 0.67% in males and females, respectively.
Results: In addition to Total‐C and LDL‐C, serum high‐density lipoprotein cholesterol and triglyceride concentrations were also significantly lower in the HCV positive subjects compared with the negative subjects, regardless of sex, age or nutritional state evaluated by body mass index. Multivariate analysis showed that HCV infection was the strongest among the factors to be significantly associated with the lower level of these lipids. Particularly, the hypolipidemia was also confirmed in the HCV positive subjects with normal aminotransferase levels (alanine aminotransferase ≤30 and aspartate aminotransferase ≤30).
Conclusion: This epidemiological survey in a large Japanese cohort suggests that the HCV infection itself might directly cause hypolipidemia, irrespective of host factors including age, hepatic damage and nutritional state. Infection with hepatitis C virus (HCV) is the leading cause of liver cirrhosis that develops into hepatocellular carcinoma. Previous studies have shown in vitro that lipids within hepatocytes are crucially important for a series of HCV infection-proliferation-release processes. On the other hand, in the patients with HCV, the serum total cholesterol (Total-C) and low-density lipoprotein cholesterol (LDL-C) levels have been reported to be lower. We conducted an epidemiological survey of a large cohort and investigated whether the lower serum lipid levels were caused by a direct or the secondary effects of HCV infection (i.e. hepatic damage or nutritional disorder). Among 146 857 participants (male, 34%; female, 66%) undergoing public health examinations between 2002 and 2007 in Ibaraki Prefecture, Japan, the HCV positive rates determined by HCV antibody/antigen and/or RNA tests were 1.37% and 0.67% in males and females, respectively. In addition to Total-C and LDL-C, serum high-density lipoprotein cholesterol and triglyceride concentrations were also significantly lower in the HCV positive subjects compared with the negative subjects, regardless of sex, age or nutritional state evaluated by body mass index. Multivariate analysis showed that HCV infection was the strongest among the factors to be significantly associated with the lower level of these lipids. Particularly, the hypolipidemia was also confirmed in the HCV positive subjects with normal aminotransferase levels (alanine aminotransferase ≤30 and aspartate aminotransferase ≤30). This epidemiological survey in a large Japanese cohort suggests that the HCV infection itself might directly cause hypolipidemia, irrespective of host factors including age, hepatic damage and nutritional state. AIM Infection with hepatitis C virus (HCV) is the leading cause of liver cirrhosis that develops into hepatocellular carcinoma. Previous studies have shown in vitro that lipids within hepatocytes are crucially important for a series of HCV infection-proliferation-release processes. On the other hand, in the patients with HCV, the serum total cholesterol (Total-C) and low-density lipoprotein cholesterol (LDL-C) levels have been reported to be lower. We conducted an epidemiological survey of a large cohort and investigated whether the lower serum lipid levels were caused by a direct or the secondary effects of HCV infection (i.e. hepatic damage or nutritional disorder). METHODS Among 146 857 participants (male, 34%; female, 66%) undergoing public health examinations between 2002 and 2007 in Ibaraki Prefecture, Japan, the HCV positive rates determined by HCV antibody/antigen and/or RNA tests were 1.37% and 0.67% in males and females, respectively. RESULTS In addition to Total-C and LDL-C, serum high-density lipoprotein cholesterol and triglyceride concentrations were also significantly lower in the HCV positive subjects compared with the negative subjects, regardless of sex, age or nutritional state evaluated by body mass index. Multivariate analysis showed that HCV infection was the strongest among the factors to be significantly associated with the lower level of these lipids. Particularly, the hypolipidemia was also confirmed in the HCV positive subjects with normal aminotransferase levels (alanine aminotransferase ≤30 and aspartate aminotransferase ≤30). CONCLUSION This epidemiological survey in a large Japanese cohort suggests that the HCV infection itself might directly cause hypolipidemia, irrespective of host factors including age, hepatic damage and nutritional state. Aim: Infection with hepatitis C virus (HCV) is the leading cause of liver cirrhosis that develops into hepatocellular carcinoma. Previous studies have shown in vitro that lipids within hepatocytes are crucially important for a series of HCV infection–proliferation–release processes. On the other hand, in the patients with HCV, the serum total cholesterol (Total‐C) and low‐density lipoprotein cholesterol (LDL‐C) levels have been reported to be lower. We conducted an epidemiological survey of a large cohort and investigated whether the lower serum lipid levels were caused by a direct or the secondary effects of HCV infection (i.e. hepatic damage or nutritional disorder). Methods: Among 146 857 participants (male, 34%; female, 66%) undergoing public health examinations between 2002 and 2007 in Ibaraki Prefecture, Japan, the HCV positive rates determined by HCV antibody/antigen and/or RNA tests were 1.37% and 0.67% in males and females, respectively. Results: In addition to Total‐C and LDL‐C, serum high‐density lipoprotein cholesterol and triglyceride concentrations were also significantly lower in the HCV positive subjects compared with the negative subjects, regardless of sex, age or nutritional state evaluated by body mass index. Multivariate analysis showed that HCV infection was the strongest among the factors to be significantly associated with the lower level of these lipids. Particularly, the hypolipidemia was also confirmed in the HCV positive subjects with normal aminotransferase levels (alanine aminotransferase ≤30 and aspartate aminotransferase ≤30). Conclusion: This epidemiological survey in a large Japanese cohort suggests that the HCV infection itself might directly cause hypolipidemia, irrespective of host factors including age, hepatic damage and nutritional state. |
Author | Ikegami, Tadashi Saitoh, Yoshifumi Hirayama, Takeshi Hara, Takashi Miyazaki, Teruo Honda, Akira Doy, Mikio Matsuzaki, Yasushi |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21501354$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1016/S1286-4579(02)01649-0 10.1038/ncb1631 10.1001/archinte.1997.00440280120012 10.1016/S0168-8278(99)80154-8 10.1016/j.tim.2005.02.004 10.1093/ajcn/55.2.488s 10.1159/000087271 10.1099/vir.0.82033-0 10.1111/j.1365-2893.2005.00655.x 10.1046/j.1365-2893.1999.6120139.x 10.1016/S0009-8981(97)06532-7 10.1136/gut.19.6.526 10.1099/vir.0.008300-0 10.1016/S0962-8924(02)02383-8 10.1016/j.cgh.2006.02.002 10.1016/j.clinbiochem.2004.03.008 10.1002/hep.23219 10.1159/000150360 10.1053/jhep.2002.35530 10.1002/hep.21261 10.1136/gut.2006.091983 10.1111/j.1572-0241.2002.07056.x 10.1111/j.1748-720X.1991.tb01822.x 10.1016/S0168-8278(00)00036-2 10.1096/fj.01-0396com 10.1128/JVI.01150-06 10.1073/pnas.96.22.12766 10.1086/506440 10.1053/jhep.2001.24432 10.1089/apc.2006.0150 10.1016/j.jhep.2008.03.016 10.1073/pnas.0700760104 10.1136/gut.51.4.585 10.1053/j.gastro.2004.11.016 10.1128/JVI.02053-07 10.1093/clinchem/18.6.499 10.1111/j.1872-034X.2007.00217.x 10.1128/JVI.76.14.6919-6928.2002 10.1053/jhep.2002.36386 10.1111/j.1872-034X.2009.00513.x 10.1194/jlr.D800017-JLR200 10.1086/599371 |
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References | Huang H, Sun F, Owen DM et al. Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteins. Proc Natl Acad Sci USA 2007; 104: 5848-53. Burlone ME, Budkowska A. Hepatitis C virus cell entry: role of lipoproteins and cellular receptors. J Gen Virol 2009; 90: 1055-70. Maggi G, Bottelli R, Gola D et al. Serum cholesterol and chronic hepatitis C. Ital J Gastroenterol 1996; 28: 436-40. McIntyre N. Plasma lipids and lipoproteins in liver disease. Gut 1978; 19: 526-30. Sakurabayashi I, Kumasaka K. Laboratory Medicine Encyclopedia & Dictionary, 1st edn. Tokyo: Ishiyaku Publishers, Inc, 2008. Floris-Moore M, Howard AA, Lo Y, Schoenbaum EE, Arnsten JH, Klein RS. Hepatitis C infection is associated with lower lipids and high-sensitivity C-reactive protein in HIV-infected men. AIDS Patient Care STDS 2007; 21: 479-91. Renou C, Halfon P, Pol S et al. Histological features and HLA class II alleles in hepatitis C virus chronically infected patients with persistently normal alanine aminotransferase levels. Gut 2002; 51: 585-90. Honda A, Yamashita K, Miyazaki H et al. Highly sensitive analysis of sterol profiles in human serum by LC-ESI-MS/MS. J Lipid Res 2008; 49: 2063-73. Dharancy S, Malapel M, Perlemuter G et al. Impaired expression of the peroxisome proliferator-activated receptor alpha during hepatitis C virus infection. Gastroenterology 2005; 128: 334-42. Miyanari Y, Atsuzawa K, Usuda N et al. The lipid droplet is an important organelle for hepatitis C virus production. Nat Cell Biol 2007; 9: 1089-97. Miyazaki T, Honda A, Ikegami T et al. The associated markers and their limitations for the primary screening of HCV carriers in public health examination. Hepatol Res 2009; 39: 664-74. Dai CY, Chuang WL, Ho CK et al. Associations between hepatitis C viremia and low serum triglyceride and cholesterol levels: a community-based study. J Hepatol 2008; 49: 9-16. Chuang WL, Yu ML, Dai CY, Chang WY. Treatment of chronic hepatitis C in southern Taiwan. Intervirology 2006; 49: 99-106. Tardif KD, Waris G, Siddiqui A. Hepatitis C virus, ER stress, and oxidative stress. Trends Microbiol 2005; 13: 159-63. Serfaty L, Andreani T, Giral P, Carbonell N, Chazouilleres O, Poupon R. Hepatitis C virus induced hypobetalipoproteinemia: a possible mechanism for steatosis in chronic hepatitis C. J Hepatol 2001; 34: 428-34. Gopal K, Johnson TC, Gopal S et al. Correlation between beta-lipoprotein levels and outcome of hepatitis C treatment. Hepatology 2006; 44: 335-40. Diaz O, Delers F, Maynard M et al. Preferential association of Hepatitis C virus with apolipoprotein B48-containing lipoproteins. J Gen Virol 2006; 87: 2983-91. Agnello V, Abel G, Elfahal M, Knight GB, Zhang QX. Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor. Proc Natl Acad Sci USA 1999; 96: 12766-71. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499-502. International guidelines for ethical review of epidemiological studies. Law Med Health Care 1991; 19: 247-58. Ikegami T, Honda A, Nakamuta M et al. Non-invasive measurement of cholesterol metabolism in patients with HCV infection by using serum marker sterols. Hepatology 2009; 50: 946A-7A. Butt AA, Xiaoqiang W, Budoff M, Leaf D, Kuller LH, Justice AC. Hepatitis C virus infection and the risk of coronary disease. Clin Infect Dis 2009; 49: 225-32. Siagris D, Christofidou M, Theocharis GJ et al. Serum lipid pattern in chronic hepatitis C: histological and virological correlations. J Viral Hepat 2006; 13: 56-61. Cicognani C, Malavolti M, Morselli-Labate AM, Zamboni L, Sama C, Barbara L. Serum lipid and lipoprotein patterns in patients with liver cirrhosis and chronic active hepatitis. Arch Intern Med 1997; 157: 792-6. Tremblay AJ, Morrissette H, Gagne JM, Bergeron J, Gagne C, Couture P. Validation of the Friedewald formula for the determination of low-density lipoprotein cholesterol compared with beta-quantification in a large population. Clin Biochem 2004; 37: 785-90. Andre P, Komurian-Pradel F, Deforges S et al. Characterization of low- and very-low-density hepatitis C virus RNA-containing particles. J Virol 2002; 76: 6919-28. Adinolfi LE, Gambardella M, Andreana A, Tripodi MF, Utili R, Ruggiero G. Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity. Hepatology 2001; 33: 1358-64. Pradat P, Alberti A, Poynard T et al. Predictive value of ALT levels for histologic findings in chronic hepatitis C: a European collaborative study. Hepatology 2002; 36: 973-7. Bray GA. Pathophysiology of obesity. Am J Clin Nutr 1992; 55: 488S-94S. Dubuisson J, Penin F, Moradpour D. Interaction of hepatitis C virus proteins with host cell membranes and lipids. Trends Cell Biol 2002; 12: 517-23. Okanoue T, Itoh Y, Minami M et al. Guidelines for the antiviral therapy of hepatitis C virus carriers with normal serum aminotransferase based on platelet counts. Hepatol Res 2008; 38: 27-36. Bacon BR. Treatment of patients with hepatitis C and normal serum aminotransferase levels. Hepatology 2002; 36: S179-84. Marzouk D, Sass J, Bakr I et al. Metabolic and cardiovascular risk profiles and hepatitis C virus infection in rural Egypt. Gut 2007; 56: 1105-10. Shiffman ML, Diago M, Tran A et al. Chronic hepatitis C in patients with persistently normal alanine transaminase levels. Clin Gastroenterol Hepatol 2006; 4: 645-52. Tassopoulos NC. EASL international consensus conference on hepatitis C Paris, 26-28 February 1999: consensus statement. J Hepatol 1999; 30: 956-61. Sanchez-Conde M, Berenguer J, Miralles P et al. Liver biopsy findings for HIV-infected patients with chronic hepatitis C and persistently normal levels of alanine aminotransferase. Clin Infect Dis 2006; 43: 640-4. Okamoto H, Mishiro S. Genetic heterogeneity of hepatitis C virus. Intervirology 1994; 37: 68-76. Fabris C, Federico E, Soardo G, Falleti E, Pirisi M. Blood lipids of patients with chronic hepatitis: differences related to viral etiology. Clin Chim Acta 1997; 261: 159-65. Gastaminza P, Cheng G, Wieland S, Zhong J, Liao W, Chisari FV. Cellular determinants of hepatitis C virus assembly, maturation, degradation, and secretion. J Virol 2008; 82: 2120-9. Hofer H, Bankl HC, Wrba F et al. Hepatocellular fat accumulation and low serum cholesterol in patients infected with HCV-3a. Am J Gastroenterol 2002; 97: 2880-5. Gastaminza P, Kapadia SB, Chisari FV. Differential biophysical properties of infectious intracellular and secreted hepatitis C virus particles. J Virol 2006; 80: 11074-81. Perlemuter G, Sabile A, Letteron P et al. Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral-related steatosis. FASEB J 2002; 16: 185-94. Japan Atherosclerosis Society. Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases. J Atheroscler Thromb 2007: 5-57. Corey KE, Kane E, Munroe C, Barlow LL, Zheng H, Chung RT. Hepatitis C virus infection and its clearance alter circulating lipids: implications for long-term follow-up. Hepatology 2009; 50: 1030-7. Ray Kim W. Global epidemiology and burden of hepatitis C. Microbes Infect 2002; 4: 1219-25. 1997; 157 2002; 16 2007; 104 2002; 36 1991; 19 2006; 13 2002; 97 2002; 51 2002; 12 2002; 76 2008; 38 1978; 19 2008 2007 2002; 4 2006; 4 1999; 6 1992; 55 2007; 56 2009; 49 2006; 80 1996; 28 2006; 87 2009; 50 1997; 261 2006; 43 2006; 44 2006; 49 2004; 37 2009; 90 2008; 49 2005; 128 2007; 9 1999; 96 1999; 30 1994; 37 2001; 33 2007; 21 2001; 34 2008; 82 1972; 18 2005; 13 2009; 39 e_1_2_6_31_2 e_1_2_6_30_2 e_1_2_6_18_2 Ikegami T (e_1_2_6_47_2) 2009; 50 e_1_2_6_19_2 e_1_2_6_12_2 e_1_2_6_35_2 e_1_2_6_13_2 Maggi G (e_1_2_6_17_2) 1996; 28 e_1_2_6_34_2 e_1_2_6_10_2 e_1_2_6_33_2 e_1_2_6_11_2 e_1_2_6_32_2 e_1_2_6_16_2 e_1_2_6_39_2 e_1_2_6_38_2 e_1_2_6_14_2 e_1_2_6_37_2 e_1_2_6_15_2 e_1_2_6_36_2 e_1_2_6_42_2 e_1_2_6_20_2 e_1_2_6_41_2 Sakurabayashi I (e_1_2_6_28_2) 2008 e_1_2_6_40_2 e_1_2_6_8_2 e_1_2_6_7_2 Japan Atherosclerosis Society (e_1_2_6_29_2) 2007 e_1_2_6_9_2 e_1_2_6_4_2 e_1_2_6_3_2 e_1_2_6_6_2 e_1_2_6_5_2 e_1_2_6_24_2 e_1_2_6_23_2 e_1_2_6_2_2 e_1_2_6_22_2 e_1_2_6_21_2 e_1_2_6_43_2 e_1_2_6_27_2 e_1_2_6_44_2 e_1_2_6_26_2 e_1_2_6_45_2 e_1_2_6_25_2 e_1_2_6_46_2 |
References_xml | – volume: 6 start-page: 35 year: 1999 end-page: 47 – volume: 82 start-page: 2120 year: 2008 end-page: 9 article-title: Cellular determinants of hepatitis C virus assembly, maturation, degradation, and secretion publication-title: J Virol – volume: 19 start-page: 247 year: 1991 end-page: 58 article-title: International guidelines for ethical review of epidemiological studies publication-title: Law Med Health Care – volume: 37 start-page: 785 year: 2004 end-page: 90 article-title: Validation of the Friedewald formula for the determination of low‐density lipoprotein cholesterol compared with beta‐quantification in a large population publication-title: Clin Biochem – volume: 36 start-page: 973 year: 2002 end-page: 7 article-title: Predictive value of ALT levels for histologic findings in chronic hepatitis C: a European collaborative study publication-title: Hepatology – volume: 39 start-page: 664 year: 2009 end-page: 74 article-title: The associated markers and their limitations for the primary screening of HCV carriers in public health examination publication-title: Hepatol Res – start-page: 5 year: 2007 end-page: 57 article-title: Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases publication-title: J Atheroscler Thromb – volume: 56 start-page: 1105 year: 2007 end-page: 10 article-title: Metabolic and cardiovascular risk profiles and hepatitis C virus infection in rural Egypt publication-title: Gut – volume: 13 start-page: 159 year: 2005 end-page: 63 article-title: Hepatitis C virus, ER stress, and oxidative stress publication-title: Trends Microbiol – volume: 261 start-page: 159 year: 1997 end-page: 65 article-title: Blood lipids of patients with chronic hepatitis: differences related to viral etiology publication-title: Clin Chim Acta – volume: 38 start-page: 27 year: 2008 end-page: 36 article-title: Guidelines for the antiviral therapy of hepatitis C virus carriers with normal serum aminotransferase based on platelet counts publication-title: Hepatol Res – volume: 19 start-page: 526 year: 1978 end-page: 30 article-title: Plasma lipids and lipoproteins in liver disease publication-title: Gut – volume: 90 start-page: 1055 year: 2009 end-page: 70 article-title: Hepatitis C virus cell entry: role of lipoproteins and cellular receptors publication-title: J Gen Virol – volume: 43 start-page: 640 year: 2006 end-page: 4 article-title: Liver biopsy findings for HIV‐infected patients with chronic hepatitis C and persistently normal levels of alanine aminotransferase publication-title: Clin Infect Dis – volume: 36 start-page: S179 year: 2002 end-page: 84 article-title: Treatment of patients with hepatitis C and normal serum aminotransferase levels publication-title: Hepatology – volume: 97 start-page: 2880 year: 2002 end-page: 5 article-title: Hepatocellular fat accumulation and low serum cholesterol in patients infected with HCV‐3a publication-title: Am J Gastroenterol – volume: 104 start-page: 5848 year: 2007 end-page: 53 article-title: Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low‐density lipoproteins publication-title: Proc Natl Acad Sci USA – volume: 33 start-page: 1358 year: 2001 end-page: 64 article-title: Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity publication-title: Hepatology – volume: 4 start-page: 1219 year: 2002 end-page: 25 article-title: Global epidemiology and burden of hepatitis C publication-title: Microbes Infect – volume: 49 start-page: 9 year: 2008 end-page: 16 article-title: Associations between hepatitis C viremia and low serum triglyceride and cholesterol levels: a community‐based study publication-title: J Hepatol – volume: 76 start-page: 6919 year: 2002 end-page: 28 article-title: Characterization of low‐ and very‐low‐density hepatitis C virus RNA‐containing particles publication-title: J Virol – volume: 12 start-page: 517 year: 2002 end-page: 23 article-title: Interaction of hepatitis C virus proteins with host cell membranes and lipids publication-title: Trends Cell Biol – volume: 157 start-page: 792 year: 1997 end-page: 6 article-title: Serum lipid and lipoprotein patterns in patients with liver cirrhosis and chronic active hepatitis publication-title: Arch Intern Med – volume: 128 start-page: 334 year: 2005 end-page: 42 article-title: Impaired expression of the peroxisome proliferator‐activated receptor alpha during hepatitis C virus infection publication-title: Gastroenterology – volume: 44 start-page: 335 year: 2006 end-page: 40 article-title: Correlation between beta‐lipoprotein levels and outcome of hepatitis C treatment publication-title: Hepatology – volume: 96 start-page: 12766 year: 1999 end-page: 71 article-title: Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor publication-title: Proc Natl Acad Sci USA – volume: 34 start-page: 428 year: 2001 end-page: 34 article-title: Hepatitis C virus induced hypobetalipoproteinemia: a possible mechanism for steatosis in chronic hepatitis C publication-title: J Hepatol – volume: 49 start-page: 225 year: 2009 end-page: 32 article-title: Hepatitis C virus infection and the risk of coronary disease publication-title: Clin Infect Dis – year: 2008 – volume: 37 start-page: 68 year: 1994 end-page: 76 article-title: Genetic heterogeneity of hepatitis C virus publication-title: Intervirology – volume: 49 start-page: 99 year: 2006 end-page: 106 article-title: Treatment of chronic hepatitis C in southern Taiwan publication-title: Intervirology – volume: 50 start-page: 946A year: 2009 end-page: 7A article-title: Non‐invasive measurement of cholesterol metabolism in patients with HCV infection by using serum marker sterols publication-title: Hepatology – volume: 28 start-page: 436 year: 1996 end-page: 40 article-title: Serum cholesterol and chronic hepatitis C publication-title: Ital J Gastroenterol – volume: 80 start-page: 11074 year: 2006 end-page: 81 article-title: Differential biophysical properties of infectious intracellular and secreted hepatitis C virus particles publication-title: J Virol – volume: 30 start-page: 956 year: 1999 end-page: 61 article-title: EASL international consensus conference on hepatitis C Paris, 26–28 February 1999: consensus statement publication-title: J Hepatol – volume: 55 start-page: 488S year: 1992 end-page: 94S article-title: Pathophysiology of obesity publication-title: Am J Clin Nutr – volume: 4 start-page: 645 year: 2006 end-page: 52 article-title: Chronic hepatitis C in patients with persistently normal alanine transaminase levels publication-title: Clin Gastroenterol Hepatol – volume: 49 start-page: 2063 year: 2008 end-page: 73 article-title: Highly sensitive analysis of sterol profiles in human serum by LC‐ESI‐MS/MS publication-title: J Lipid Res – volume: 87 start-page: 2983 year: 2006 end-page: 91 article-title: Preferential association of Hepatitis C virus with apolipoprotein B48‐containing lipoproteins publication-title: J Gen Virol – volume: 13 start-page: 56 year: 2006 end-page: 61 article-title: Serum lipid pattern in chronic hepatitis C: histological and virological correlations publication-title: J Viral Hepat – volume: 16 start-page: 185 year: 2002 end-page: 94 article-title: Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral‐related steatosis publication-title: FASEB J – volume: 50 start-page: 1030 year: 2009 end-page: 7 article-title: Hepatitis C virus infection and its clearance alter circulating lipids: implications for long‐term follow‐up publication-title: Hepatology – volume: 18 start-page: 499 year: 1972 end-page: 502 article-title: Estimation of the concentration of low‐density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge publication-title: Clin Chem – volume: 9 start-page: 1089 year: 2007 end-page: 97 article-title: The lipid droplet is an important organelle for hepatitis C virus production publication-title: Nat Cell Biol – volume: 51 start-page: 585 year: 2002 end-page: 90 article-title: Histological features and HLA class II alleles in hepatitis C virus chronically infected patients with persistently normal alanine aminotransferase levels publication-title: Gut – volume: 21 start-page: 479 year: 2007 end-page: 91 article-title: Hepatitis C infection is associated with lower lipids and high‐sensitivity C‐reactive protein in HIV‐infected men publication-title: AIDS Patient Care STDS – start-page: 5 year: 2007 ident: e_1_2_6_29_2 article-title: Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases publication-title: J Atheroscler Thromb contributor: fullname: Japan Atherosclerosis Society – ident: e_1_2_6_3_2 doi: 10.1016/S1286-4579(02)01649-0 – ident: e_1_2_6_9_2 doi: 10.1038/ncb1631 – ident: e_1_2_6_22_2 doi: 10.1001/archinte.1997.00440280120012 – volume: 50 start-page: 946A year: 2009 ident: e_1_2_6_47_2 article-title: Non‐invasive measurement of cholesterol metabolism in patients with HCV infection by using serum marker sterols publication-title: Hepatology contributor: fullname: Ikegami T – ident: e_1_2_6_23_2 doi: 10.1016/S0168-8278(99)80154-8 – ident: e_1_2_6_44_2 doi: 10.1016/j.tim.2005.02.004 – ident: e_1_2_6_30_2 doi: 10.1093/ajcn/55.2.488s – ident: e_1_2_6_41_2 doi: 10.1159/000087271 – ident: e_1_2_6_6_2 doi: 10.1099/vir.0.82033-0 – ident: e_1_2_6_16_2 doi: 10.1111/j.1365-2893.2005.00655.x – ident: e_1_2_6_2_2 doi: 10.1046/j.1365-2893.1999.6120139.x – ident: e_1_2_6_19_2 doi: 10.1016/S0009-8981(97)06532-7 – ident: e_1_2_6_21_2 doi: 10.1136/gut.19.6.526 – ident: e_1_2_6_7_2 doi: 10.1099/vir.0.008300-0 – ident: e_1_2_6_8_2 doi: 10.1016/S0962-8924(02)02383-8 – ident: e_1_2_6_25_2 doi: 10.1016/j.cgh.2006.02.002 – ident: e_1_2_6_27_2 doi: 10.1016/j.clinbiochem.2004.03.008 – ident: e_1_2_6_15_2 doi: 10.1002/hep.23219 – ident: e_1_2_6_40_2 doi: 10.1159/000150360 – ident: e_1_2_6_34_2 doi: 10.1053/jhep.2002.35530 – ident: e_1_2_6_42_2 doi: 10.1002/hep.21261 – ident: e_1_2_6_18_2 doi: 10.1136/gut.2006.091983 – ident: e_1_2_6_38_2 doi: 10.1111/j.1572-0241.2002.07056.x – ident: e_1_2_6_31_2 doi: 10.1111/j.1748-720X.1991.tb01822.x – volume-title: Laboratory Medicine Encyclopedia & Dictionary year: 2008 ident: e_1_2_6_28_2 contributor: fullname: Sakurabayashi I – ident: e_1_2_6_37_2 doi: 10.1016/S0168-8278(00)00036-2 – volume: 28 start-page: 436 year: 1996 ident: e_1_2_6_17_2 article-title: Serum cholesterol and chronic hepatitis C publication-title: Ital J Gastroenterol contributor: fullname: Maggi G – ident: e_1_2_6_43_2 doi: 10.1096/fj.01-0396com – ident: e_1_2_6_11_2 doi: 10.1128/JVI.01150-06 – ident: e_1_2_6_5_2 doi: 10.1073/pnas.96.22.12766 – ident: e_1_2_6_33_2 doi: 10.1086/506440 – ident: e_1_2_6_39_2 doi: 10.1053/jhep.2001.24432 – ident: e_1_2_6_36_2 doi: 10.1089/apc.2006.0150 – ident: e_1_2_6_14_2 doi: 10.1016/j.jhep.2008.03.016 – ident: e_1_2_6_10_2 doi: 10.1073/pnas.0700760104 – ident: e_1_2_6_35_2 doi: 10.1136/gut.51.4.585 – ident: e_1_2_6_45_2 doi: 10.1053/j.gastro.2004.11.016 – ident: e_1_2_6_12_2 doi: 10.1128/JVI.02053-07 – ident: e_1_2_6_26_2 doi: 10.1093/clinchem/18.6.499 – ident: e_1_2_6_32_2 doi: 10.1111/j.1872-034X.2007.00217.x – ident: e_1_2_6_4_2 doi: 10.1128/JVI.76.14.6919-6928.2002 – ident: e_1_2_6_24_2 doi: 10.1053/jhep.2002.36386 – ident: e_1_2_6_20_2 doi: 10.1111/j.1872-034X.2009.00513.x – ident: e_1_2_6_46_2 doi: 10.1194/jlr.D800017-JLR200 – ident: e_1_2_6_13_2 doi: 10.1086/599371 |
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SubjectTerms | health examination high-density lipoprotein cholesterol low-density lipoprotein cholesterol total cholesterol triglyceride |
Title | Hepatitis C virus infection causes hypolipidemia regardless of hepatic damage or nutritional state: An epidemiological survey of a large Japanese cohort |
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