PD-L1 gene polymorphisms and low serum level of PD-L1 protein are associated to type 1 diabetes in Chile

• Published in: Diabetes/metabolism research and reviews Vol. 30; no. 8; pp. 761 - 766
• Main Authors: Pizarro, Carolina, García-Díaz, Diego F., Codner, Ethel, Salas-Pérez, Francisca, Carrasco, Elena, Pérez-Bravo, Francisco
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.11.2014; Wiley Subscription Services, Inc
• Subjects: Adolescent; Age of Onset; Alleles; Autoimmunity; B7-H1 Antigen - blood; B7-H1 Antigen - genetics; B7-H1 Antigen - metabolism; Case-Control Studies; Child; Child, Preschool; Chile - epidemiology; Cohort Studies; Diabetes Mellitus, Type 1 - epidemiology; Diabetes Mellitus, Type 1 - genetics; Diabetes Mellitus, Type 1 - immunology; Diabetes Mellitus, Type 1 - metabolism; Down-Regulation; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Infant; Linkage Disequilibrium; Male; PD-1 ligand polymorphisms; PD-L1; PD-L2; Polymorphism, Single Nucleotide; Programmed Cell Death 1 Ligand 2 Protein - genetics; Programmed Cell Death 1 Ligand 2 Protein - metabolism; type 1 diabetes; PD-L1; PD-L2; type 1 diabetes; PD-1 ligand polymorphisms

Introduction Type 1 diabetes (T1D) has a complex etiology in which genetic and environmental factors are involved, whose interactions have not yet been completely clarified. In this context, the role in PD‐1 pathway and its ligands 1 and 2 (PD‐L1 and PD‐L2) have been proposed as candidates in severa...