Outcome of Pregnancy in Women with Moderate or Severe Renal Insufficiency

• Published in: The New England journal of medicine Vol. 335; no. 4; pp. 226 - 232
• Main Authors: Jones, David C, Hayslett, John P
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 25.07.1996
• Subjects: Adult; Biological and medical sciences; Blood pressure; Creatinine - blood; Female; Follow-Up Studies; Glomerular Filtration Rate; Glomerulonephritis - complications; Glomerulonephritis - physiopathology; Humans; Hypertension; Hypertension - complications; Infant, Newborn; Infant, Premature; Kidney - physiopathology; Kidney diseases; Medical sciences; Nephritis, Interstitial - complications; Nephritis, Interstitial - physiopathology; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; Pregnancy; Pregnancy Complications - physiopathology; Pregnancy Complications, Cardiovascular; Pregnancy Outcome; Renal failure; Renal Insufficiency - complications; Renal Insufficiency - physiopathology; Womens health; Pregnancy; Human; Urinary system disease; Renal failure; Renal disease; Complication; Evolution; Female; Severity score
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJM199607253350402

The editorial comment “children of women with renal disease used to be born dangerously or not at all — not at all if their doctors had their way,” 1 reflects an early view of the effect of kidney disease on pregnancy. However, among pregnant women with mild renal insufficiency (serum creatinine, <1.4 mg per deciliter [124 μmol per liter]) fetal survival is only moderately reduced and the underlying disease is not irreversibly worsened. 2 – 6 In contrast, the presence of moderate or severe renal insufficiency in pregnancy has been reported to accelerate the underlying disease and markedly reduce fetal survival. 2 , 7 This . . .