Oncogenic MCT-1 activation promotes YY1-EGFR-MnSOD signaling and tumor progression

• Published in: Oncogenesis (New York, NY) Vol. 6; no. 4; p. e313
• Main Authors: Tseng, H-Y, Chen, Y-A, Jen, J, Shen, P-C, Chen, L-M, Lin, T-D, Wang, Y-C, Hsu, H-L
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.04.2017; Nature Publishing Group
• Subjects: 13/1; 13/105; 13/109; 13/31; 631/67/1612/1350; 631/67/2327; 631/67/327; 64/60; 82/51; 82/80; Apoptosis; Cell Biology; Gene expression; Human Genetics; Internal Medicine; Medicine; Medicine & Public Health; Oncology; Original; original-article; Oxidative stress; Proteins; Signal transduction; Tumorigenesis

Tumor cells often produce high levels of reactive oxygen species (ROS) and display an increased ROS scavenging system. However, the molecular mechanism that balances antioxidative and oxidative stress in cancer cells is unclear. Here, we determined that oncogenic multiple copies in T-cell malignancy...