Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery - Yu, Jicheng; Yuqi Zhang; Yanqi Ye; Rocco DiSanto; Wujin Sun; Davis Ranson; Frances S. Ligler; John B. Buse; Zhen Gu (Proceedings of the National Academy of Sciences - PNAS, 2015)
Keywords: anaerobic conditions; animal models; Animals; Biological Sciences; blood glucose; Blood Glucose - analysis; Diabetes; Diabetes Mellitus, Experimental - blood; Diabetes Mellitus, Experimental - drug therapy; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - drug therapy; dissociation; drug delivery; Drug delivery systems; Drug Delivery Systems - instrumentation; Drug Delivery Systems - methods; Glucose; Glucose - metabolism; glucose oxidase; Glucose Oxidase - metabolism; glucose-responsive; Humans; hyaluronic acid; Hyaluronic Acid - chemistry; Hyaluronic Acid - metabolism; hydrophilicity; Hydrophobic surfaces; hydrophobicity; hyperglycemia; hypoglycemia; Hypoglycemic Agents - administration & dosage; Hypoglycemic Agents - chemistry; Hypoxia; Hypoxia - metabolism; hypoxia-sensitive; Insulin; Insulin - administration & dosage; Insulin - chemistry; Insulin - metabolism; insulin-dependent diabetes mellitus; Male; Mice, Inbred C57BL; microneedle; Microscopy, Electron, Transmission; Molecular Structure; oxidation; Oxidation-Reduction; Quality of life; Reproducibility of Results; therapeutics; Transdermal medication; glucose-responsive; microneedle; drug delivery; hypoxia-sensitive; diabetes