MYC protein stability is negatively regulated by BRD4

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 117; no. 24; pp. 13457 - 13467
• Main Authors: Devaiah, Ballachanda N., Mu, Jie, Akman, Ben, Uppal, Sheetal, Weissman, Jocelyn D., Cheng, Dan, Baranello, Laura, Nie, Zuqin, Levens, David, Singer, Dinah S.
• Format: Journal Article
• Language: English
• Published: Washington National Academy of Sciences 16.06.2020
• Subjects: Activation; Biological Sciences; Chromatin remodeling; Degradation; Extracellular signal-regulated kinase; Histone acetyltransferase; Kinases; Myc protein; Phosphorylation; Proteins; Stability; Transcription; Ubiquitination

The protooncogene MYC regulates a variety of cellular processes, including proliferation and metabolism. Maintaining MYC at homeostatic levels is critical to normal cell function; overexpression drives many cancers. MYC stability is regulated through phosphorylation: phosphorylation at Thr58 signals...