The cost-effectiveness of screening men who have sex with men for rectal chlamydial and gonococcal infection to prevent HIV Infection

Men who have sex with men (MSM) who have a current or recent history of rectal Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) infection are at greater risk for HIV than MSM with no history of rectal infection. Screening and treating MSM for rectal CT/GC infection may help reduce any incre...

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Published inSexually transmitted diseases Vol. 40; no. 5; p. 366
Main Authors Chesson, Harrell W, Bernstein, Kyle T, Gift, Thomas L, Marcus, Julia L, Pipkin, Sharon, Kent, Charlotte K
Format Journal Article
LanguageEnglish
Published United States 01.05.2013
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Abstract Men who have sex with men (MSM) who have a current or recent history of rectal Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) infection are at greater risk for HIV than MSM with no history of rectal infection. Screening and treating MSM for rectal CT/GC infection may help reduce any increased biological susceptibility to HIV infection. We used 2 versions of a Markov state-transition model to examine the impact and cost-effectiveness of screening MSM for rectal CT/GC infection in San Francisco: a static version that included only the benefits to those screened and a dynamic version that accounted for population-level impacts of screening. HIV prevention through reduced susceptibility to HIV was the only potential benefit of rectal CT/GC screening that we included in our analysis. Parameter values were based on San Francisco program data and the literature. In the base case, the cost per quality-adjusted life year gained through screening MSM for rectal CT/GC infection was $16,300 in the static version of the model. In the dynamic model, the cost per quality-adjusted life year gained was less than $0, meaning that rectal screening was cost-saving. The impact of rectal CT/GC infection on the risk of HIV acquisition was the most influential model parameter. Although more information is needed regarding the impact of rectal CT/GC screening on HIV incidence, rectal CT/GC screening of MSM can potentially be a cost-effective, scalable intervention targeted to at-risk MSM in certain urban settings such as San Francisco.
AbstractList Men who have sex with men (MSM) who have a current or recent history of rectal Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) infection are at greater risk for HIV than MSM with no history of rectal infection. Screening and treating MSM for rectal CT/GC infection may help reduce any increased biological susceptibility to HIV infection. We used 2 versions of a Markov state-transition model to examine the impact and cost-effectiveness of screening MSM for rectal CT/GC infection in San Francisco: a static version that included only the benefits to those screened and a dynamic version that accounted for population-level impacts of screening. HIV prevention through reduced susceptibility to HIV was the only potential benefit of rectal CT/GC screening that we included in our analysis. Parameter values were based on San Francisco program data and the literature. In the base case, the cost per quality-adjusted life year gained through screening MSM for rectal CT/GC infection was $16,300 in the static version of the model. In the dynamic model, the cost per quality-adjusted life year gained was less than $0, meaning that rectal screening was cost-saving. The impact of rectal CT/GC infection on the risk of HIV acquisition was the most influential model parameter. Although more information is needed regarding the impact of rectal CT/GC screening on HIV incidence, rectal CT/GC screening of MSM can potentially be a cost-effective, scalable intervention targeted to at-risk MSM in certain urban settings such as San Francisco.
Author Bernstein, Kyle T
Marcus, Julia L
Chesson, Harrell W
Kent, Charlotte K
Pipkin, Sharon
Gift, Thomas L
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Snippet Men who have sex with men (MSM) who have a current or recent history of rectal Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) infection are at...
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StartPage 366
SubjectTerms Adult
Chlamydia Infections - diagnosis
Chlamydia Infections - economics
Chlamydia Infections - epidemiology
Chlamydia trachomatis - isolation & purification
Cost-Benefit Analysis
Gonorrhea - diagnosis
Gonorrhea - economics
Gonorrhea - epidemiology
HIV Infections - economics
HIV Infections - epidemiology
HIV Infections - prevention & control
Homosexuality, Male - statistics & numerical data
Humans
Incidence
Male
Markov Chains
Mass Screening - economics
Neisseria gonorrhoeae - isolation & purification
Quality-Adjusted Life Years
Rectal Diseases - diagnosis
Rectal Diseases - economics
Rectal Diseases - epidemiology
Rectal Diseases - microbiology
San Francisco - epidemiology
Sexual Behavior
Surveys and Questionnaires
Title The cost-effectiveness of screening men who have sex with men for rectal chlamydial and gonococcal infection to prevent HIV Infection
URI https://www.ncbi.nlm.nih.gov/pubmed/23588125
Volume 40
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