Adult-onset Still's disease in focus: Clinical manifestations, diagnosis, treatment, and unmet needs in the era of targeted therapies

• Published in: Seminars in arthritis and rheumatism Vol. 51; no. 4; pp. 858 - 874
• Main Authors: Efthimiou, Petros, Kontzias, Apostolos, Hur, Peter, Rodha, Kavita, Ramakrishna, G S, Nakasato, Priscila
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.08.2021
• Subjects: Adult-onset still's disease; AOSD; Biologics; Diagnosis; Novel biomarkers; Unmet needs; CRP; LRG; FDA; RCT; HLH; NSAID; Adult-onset still's disease; SJIA; HO-1; SLE; IFN; Novel biomarkers; NLR; Biologics; SLR; Diagnosis; US; AOSD; FUO; USA; Unmet needs; IL; ESR; DMARD; PRISMA; RA; ACR; ANA; RF; JAK; HLA; MAS; Cyr61

•AOSD is a rare multisystem inflammatory disease characterized by spiking high fevers, arthritis or arthralgia, maculopapular salmon-colored rash, neutrophilic leukocytosis, and hyperferritinemia.•Emerging evidence suggest that AOSD and SJIA are part of the same disease continuum with different ages...