The Role of Serum 5-HIAA as a Predictor of Progression and an Alternative to 24-h Urine 5-HIAA in Well-Differentiated Neuroendocrine Neoplasms

• Published in: Biology (Basel, Switzerland) Vol. 10; no. 2; p. 76
• Main Authors: Wedin, Maria, Mehta, Sagar, Angerås-Kraftling, Jenny, Wallin, Göran, Daskalakis, Kosmas
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.01.2021; MDPI
• Subjects: 5-HIAA; Acids; Biomarkers; Computed tomography; Disease; Ethics; Hormones; Laboratories; Liver; Magnetic resonance imaging; Medical prognosis; Metastases; Metastasis; neuroendocrine neoplasm; Neuroendocrine tumors; Patients; Peptides; Plasma; Renal function; Serotonin; Surgery; Surveillance; Tumors; Urine; United States > US; Sweden; 5-HIAA; biomarkers; neuroendocrine neoplasm

Our aim was to investigate the clinical utility of serum 5HIAA for disease surveillance and diagnostic purposes in a cohort of patients with well-differentiated neuroendocrine neoplasms (WD-NENs). Forty-eight patients with WD-NENs and concurrent serum and urinary 5HIAA testing, as well as CT/MRI ima...