The Spectrum and Impact of Metabolic Dysfunction in MAFLD: A Longitudinal Cohort Analysis of 32,683 Overweight and Obese Individuals

• Published in: Clinical gastroenterology and hepatology Vol. 21; no. 10; pp. 2560 - 2569.e15
• Main Authors: Chan, Kai En, Ng, Cheng Han, Fu, Clarissa Elysia, Quek, Jingxuan, Kong, Gwyneth, Goh, Yi Jie, Zeng, Rebecca Wenling, Tseng, Michael, Aggarwal, Manik, Nah, Benjamin, Chee, Douglas, Wong, Zhen Yu, Zhang, Sitong, Wang, Jiong-Wei, Chew, Nicholas W.S., Dan, Yock Young, Siddiqui, Mohammad Shadab, Noureddin, Mazen, Sanyal, Arun J., Muthiah, Mark
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2023
• Subjects: Adverse Outcomes; All-Cause Mortality; Gastroenterology and Hepatology; Metabolic Diseases; Metabolic-associated Fatty Liver Disease; Nonalcoholic Fatty Liver Disease; FLI; NAFLD; OR; CI; Metabolic Diseases; MU; DM; HR; Metabolic-associated Fatty Liver Disease; CVD; MAFLD; Adverse Outcomes; MACE; VCTE; Nonalcoholic Fatty Liver Disease; NHANES; MH; SHR; All-Cause Mortality; BMI; metabolic associated fatty liver disease; diabetes mellitus; odds ratio; subdistribution hazard ratio; major adverse cardiovascular events; metabolically unhealthy; cardiovascular disease; body mass index; vibration-controlled transient elastography; fatty liver index; metabolically healthy; hazard ratio; confidence interval; National Health and Nutrition Examination Survey

Metabolic associated fatty liver disease (MAFLD) was recently proposed as an alternative name change for better encapsulation of disease. However, there exists a spectrum of MAFLD where both metabolically healthy (MH) and metabolically unhealthy (MU) individuals are included. In view of limited evid...