Variable Dendritic Integration in Hippocampal CA3 Pyramidal Neurons

• Published in: Neuron (Cambridge, Mass.) Vol. 80; no. 6; pp. 1438 - 1450
• Main Authors: Makara, Judit K., Magee, Jeffrey C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 18.12.2013; Elsevier Limited; Cell Press
• Subjects: Action Potentials - physiology; Animals; Brain; CA3 Region, Hippocampal - physiology; Dendrites - physiology; Experiments; G Protein-Coupled Inwardly-Rectifying Potassium Channels - physiology; Glutamic Acid - pharmacology; Male; N-Methylaspartate - physiology; Neurons; Potassium Channels; Pyramidal Cells - physiology; Rats; Sodium - physiology

The hippocampal CA3 region is essential for pattern completion and generation of sharp-wave ripples. During these operations, coordinated activation of ensembles of CA3 pyramidal neurons produces spatiotemporally structured input patterns arriving onto dendrites of recurrently connected CA3 neurons....