HIF-1-Independent Mechanisms Regulating Metabolic Adaptation in Hypoxic Cancer Cells

• Published in: Cells (Basel, Switzerland) Vol. 10; no. 9; p. 2371
• Main Authors: Lee, Shen-Han, Golinska, Monika, Griffiths, John R.
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 09.09.2021; MDPI
• Subjects: 1-Phosphatidylinositol 3-kinase; Adenosine triphosphate; AKT protein; AMP-activated protein kinase; Angiogenesis; Autophagy; Binding sites; Cancer; cancer metabolism; Carbohydrate metabolism; Clinical trials; Creatine; creatine metabolism; Dehydrogenases; Drug resistance; Enzymes; Epigenetics; Genomics; Glucose; Glucose metabolism; Glutamine; glycolysis; Hypoxia; Hypoxia-inducible factor 1; Hypoxia-inducible factor 1a; hypoxia-inducible factor-1 (HIF-1); Kinases; Lipid metabolism; Metabolism; Metastasis; Microenvironments; Myc; Myc protein; Phosphorylation; Post-translation; Protein turnover; Review; Signal transduction; Solid tumors; Transcription factors; Tumors

In solid tumours, cancer cells exist within hypoxic microenvironments, and their metabolic adaptation to this hypoxia is driven by HIF-1 transcription factor, which is overexpressed in a broad range of human cancers. HIF inhibitors are under pre-clinical investigation and clinical trials, but there...