Fine specificities of natural regulatory T cells after IVIG therapy in patients with Kawasaki disease

• Published in: Autoimmunity (Chur, Switzerland) Vol. 48; no. 3; pp. 181 - 188
• Main Authors: Burns, Jane C., Touma, Ranim, Song, Yali, Padilla, Robert L., Tremoulet, Adriana H., Sidney, John, Sette, Alessandro, Franco, Alessandra
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.05.2015; Informa Healthcare
• Subjects: Acute Disease; Adolescent; Adult; Amino Acid Sequence; Case-Control Studies; Child; Convalescence; Coronary Artery Disease - immunology; Coronary Artery Disease - pathology; Coronary Artery Disease - prevention & control; Female; Humans; immune-regulation; Immunoglobulin Fc Fragments - chemistry; Immunoglobulin Fc Fragments - genetics; Immunoglobulin Fc Fragments - immunology; Immunoglobulins, Intravenous - therapeutic use; Immunologic Factors; Immunologic Memory; Immunotherapy; Interleukin-10 - immunology; Interleukin-10 - secretion; IVIG; Kawasaki disease; Lymphocyte Activation - drug effects; Male; Molecular Sequence Data; Mucocutaneous Lymph Node Syndrome - drug therapy; Mucocutaneous Lymph Node Syndrome - immunology; Mucocutaneous Lymph Node Syndrome - pathology; natural Treg; Peptides - chemistry; Peptides - immunology; Peptides - pharmacology; Primary Cell Culture; T-Lymphocytes, Regulatory - drug effects; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - pathology; Time Factors; IVIG; immune-regulation; Kawasaki disease; natural Treg; Immunotherapy

Abstract The activation of natural regulatory T cells (nTreg) recognizing the heavy constant region (Fc) of IgG is an important mechanism of action of intravenous immunoglobulin (IVIG) therapy in Kawasaki disease (KD). Lack of circulating Fc-specific nTreg in the sub-acute phase of KD is correlated...