Perivascular adipose tissue-derived nitric oxide compensates endothelial dysfunction in aged pre-atherosclerotic apolipoprotein E-deficient rats

• Published in: Vascular pharmacology Vol. 142; p. 106945
• Main Authors: Nakladal, D., Sijbesma, J.W.A., Visser, L.M., Tietge, U.J.F., Slart, R.H.J.A., Deelman, L.E., Henning, R.H., Hillebrands, J.L., Buikema, H.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2022; Elsevier Science Ltd
• Subjects: Adiponectin; Adipose tissue; Adipose Tissue - metabolism; Animals; Aorta; Apolipoprotein E; Apolipoproteins; Apolipoproteins E - genetics; Arteriosclerosis; Atherosclerosis; Atherosclerosis - metabolism; Body fat; Cholesterol; Cholinergics; Diet; Endothelium; Gene expression; High fat diet; Hyperlipidemia; IL-1β; Inflammation; Interleukin 6; Macrophages; Medicin och hälsovetenskap; Monocyte chemoattractant protein 1; Nitric oxide; Nitric Oxide - metabolism; Nitric-oxide synthase; Perivascular adipose tissue; Positron Emission Tomography Computed Tomography; Rats; Rats, Sprague-Dawley; Thickness ratio; Triglycerides; Vascular relaxation; [18F]FDG; Perivascular adipose tissue; WAT; Vascular relaxation; CT; EDR; Apolipoprotein E; BAT; PE; KCl; LDL; FFPE; Nitric oxide; VLDL; Atherosclerosis; ApoE; L-NMMA; PVAT; LDLr; EDHF; Emax; CHD; PET

Atherosclerosis is a major contributor to global mortality and is accompanied by vascular inflammation and endothelial dysfunction. Perivascular adipose tissue (PVAT) is an established regulator of vascular function with emerging implications in atherosclerosis. We investigated the modulation of aor...