Congenital taurine deficiency in mice is associated with reduced sensitivity to nociceptive chemical stimulation

• Published in: Neuroscience Vol. 259; pp. 63 - 70
• Main Authors: Lötsch, J., Hummel, T., Warskulat, U., Coste, O., Häussinger, D., Geisslinger, G., Tegeder, I.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 14.02.2014; Elsevier
• Subjects: Analysis of Variance; Animals; Biological and medical sciences; Carbon Dioxide - pharmacology; Formaldehyde - adverse effects; Fundamental and applied biological sciences. Psychology; Hyperalgesia - genetics; Hyperalgesia - physiopathology; knock-out model; Membrane Glycoproteins - deficiency; Membrane Transport Proteins - deficiency; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurology; Nociception - physiology; pain; Pain Measurement - drug effects; Pain Threshold - physiology; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors; Stimulation, Chemical; Taurine - metabolism; Time Factors; Vertebrates: nervous system and sense organs; NMP; HSAN; pain; rm-ANOVA; knock-out model; mice; analysis of variance for repeated measures; negative mucosa potential; hereditary sensory and autonomic neuropathy; Nociception; Taurine; Rodentia; Stimulation; Vertebrata; Sensitivity; Mammalia; Pain; Mouse; Animal; Models

•Chronic loss of intracellular taurine leads to neuro-sensory deficits.•This extends to the responses to chemical nociceptive stimuli.•Taurine transport might be a novel target of analgesics. The amino acid taurine is required for development and functioning of the central and peripheral nervous sys...