Quantitative analysis of redox proteome reveals oxidation-sensitive protein thiols acting in fundamental processes of developmental hematopoiesis

• Published in: Redox biology Vol. 53; p. 102343
• Main Authors: Pimkova, K., Jassinskaja, M., Munita, R., Ciesla, M., Guzzi, N., Cao Thi Ngoc, P., Vajrychova, M., Johansson, E., Bellodi, C., Hansson, J.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2022; Elsevier
• Subjects: Animals; Basic Medicine; Biologi; Biological Sciences; Cell Biology; Cellbiologi; Cysteine oxidative modifications; Cysteine/metabolism; Developmental biology; Hematopoiesis; Leukemia; Medical and Health Sciences; Medical Genetics; Medicin och hälsovetenskap; Medicinsk genetik; Medicinska och farmaceutiska grundvetenskaper; Mice; Natural Sciences; Naturvetenskap; Oxidation-Reduction; Protein translation; Proteome/metabolism; Proteomics; Redox proteomics; Research Paper; Sulfhydryl Compounds; Redox proteomics; Hematopoiesis; Developmental biology; Cysteine oxidative modifications; Leukemia; MLL-ENL; HSPCs; Cys; Protein translation

Fetal and adult hematopoietic stem and progenitor cells (HSPCs) are characterized by distinct redox homeostasis that may influence their differential cellular behavior in normal and malignant hematopoiesis. In this work, we have applied a quantitative mass spectrometry-based redox proteomic approach...